Elevated plasma asymmetric dimethyl‐<scp>L</scp>‐arginine levels are linked to endothelial progenitor cell depletion and carotid atherosclerosis in rheumatoid arthritis

Surdacki, Andrzej; Martens‐Lobenhoffer, Jens; Włoch, Alicja; Marewicz, Ewa; Rakowski, Tomasz; Wieczorek-Surdacka, Ewa; Dubiel, Jacek S.; Pryjma, J; Bode‐Böger, Stefanie M.

doi:10.1002/art.22424

Cited by 105 publications

(71 citation statements)

References 64 publications

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“…Our results support both Turiel et al [22,30] and Surdacki et al studies [21,31] in terms of the relation between ADMA and inflammation. Surdacki et al displayed that neither ADMA nor SDMA (symmetric dimethylarginine) were correlated with the disease activity and inflammatory activation [21,31]. It has also been shown [30] that anti-inflammatuar therapy had no effect on ADMA levels.…”

Section: Discussionsupporting

confidence: 92%

“…Therefore, the authors suggested that increased ADMA levels were related with the decrease in CFR [3]. Although one study [21] showed an association between ADMA and common carotid intimae media thickness (IMT), other studies failed to find a relation between ADMA levels and IMT [22,23]. A decrease in DDAH activity may be one of the reasons of high ADMA levels in the RA patients.…”

Section: Discussionmentioning

confidence: 99%

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Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis

Vatansev

Öztürk²,

Yılmaz

et al. 2013

Turk J Bioch

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Objective: Rheumatoid arthritis (RA) is a chronic inflammatory disease and it is associated with premature atherosclerosis development. RA patients have multiple factors to develop premature atherosclerosis. Enhanced asymmetric dimethylarginine (ADMA) is considered as a risk factor for the development of atherosclerosis by inducing endothelial dysfunction. The aim of this study was to investigate the role of asymmetric dimethylarginine, arginine and citrulline levels in patients with RA and their relation to the disease activity parameters for possible role on the disease activity. Methods: 92 patients with RA and 34 healthy controls were included the study. Patients and control blood samples collected for ADMA, arginine and citrulline levels. ADMA, arginine and citrulline levels were measured by pre-column derivatization fluorescence HPLC method. CRP and ESR levels examined on the same day were taken from the patient records. Results: While ADMA levels significantly increased, arginine levels decreased in the patient group. There was no difference in citrulline levels between both groups. Only citrulline and arginine showed a weak positive correlation. ADMA, arginine, and citrulline levels showed no correlation with either biochemical parameters such as CRP or ESR, or disease activity or disease severity. Conclusion: Our study has shown that an increase in ADMA levels with the decrease in arginine levels suggests an increase in arginine turnover to ADMA. Increased ADMA levels can be used for an increased risk for premature development of atherosclerosis in patients with RA. Since high ADMA levels prevent the NO-dependent vasodilatation, a possible role of ADMA in development of premature atherosclerosis may be independent from inflammation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis

Vatansev

Öztürk²,

Yılmaz

et al. 2013

Turk J Bioch

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“…In a study by Surdacki et al (30), it was reported that ADMA levels and carotid IMT values were higher in patients with RA compared to the control group and that ADMA levels and carotid IMT values were correlated. Kiani et al (31) found high ADMA levels in patients with systemic lupus erythematosus (SLE) and an association between these levels and coronary calcium level.…”

Section: Discussionmentioning

confidence: 96%

Romatoid Artritli Hastalarda ADMA Düzeyleri ile Karotid Arter Intima-Media Kalınlığı Arasındaki İlişkinin Saptanması

Karaoğlan¹,

Öztürk²,

Özdoğan³

et al. 2011

Tftr

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Objective: Plasma asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, is related to increased cardiovascular risks, endothelial dysfunction and atherosclerosis. Carotid artery intima-media thickness (IMT) is closely related to the risk of coronary artery disease. We aimed to investigate plasma ADMA levels and its relation to carotid IMT in patients with rheumatoid arthritis (RA). Materials and Methods: Eighteen Turkish patients with RA (16 females, mean age: 49.44±8.88 years) and 18 age-and gender-matched healthy controls (16 females, mean age: 46.28±4.97 years) were included in the study. Measurement of IMT was done by B-mode ultrasound. Plasma ADMA levels and carotid IMT of both sides were measured in all patients and healthy controls, and the means of the two groups were compared. The correlation between ADMA levels and carotid IMT was assessed in patients with RA. Results: Plasma ADMA levels were significantly higher in patients compared to healthy controls. Although the carotid IMT values were relatively higher in the patient group than in the control group, the difference was not statistically significant. There was no significant correlation between ADMA levels and carotid IMT values. Conclusion: Our findings support the notion that plasma ADMA levels are elevated in patients with RA. Despite lack of correlation between ADMA levels and IMT in our study, ADMA levels can be used to evaluate endothelial dysfunction. Turk J Phys Med Re hab 2011;57:114-8. Key Words: Rheumatoid arthritis, ADMA, carotid IMT Özet Amaç: Nitrik oksit sentezinin endojen inhibitörü olan asimetrik dimetilargininin (ADMA) plazma düzeyleri, artmış kardiyovasküler risk, endotelyal disfonksiyon ve ateroskleroz ile ilişkilidir. Karotid arter intima-media kalınlığı (IMT), koroner arter hastalık gelişimi riski ile yakından ilişkilidir. Biz bu çalış-mamızda romatoid artritli hastalarda plazma ADMA düzeylerini belirlemeyi ve bunun karotid IMT ile arasındaki ilişkiyi incelemeyi amaçladık. Gereç ve Yöntem: Araştırmamıza romatoid artrit tanısı konulan 18 Türk hasta (16 kadın, 2 erkek; yaş ortalamaları 49,44±8,88 yıl) ve 18 sağlıklı gönüllü (16 kadın, 2 erkek; yaş ortalamaları 46,28±4,97 yıl) dahil edildi. IMT ölçümü B-mode ultrasonografi ile değerlendirildi. Hasta ve sağlıklı gönüllülerin plazma ADMA düzeyleri ile her iki taraf karotid arter intima-media kalınlıkları ölçülerek iki grubun ortalamaları karşılaştırıldı. Ayrıca romatoid artritli hastaların ADMA düzeyle-rinin karotid arter intima-media kalınlıkları ile olan korelasyonu değerlendirildi. Bulgular: Plazma ADMA düzeyleri hasta grubunda kontrol grubuna göre anlamlı derecede yüksekti. Karotid arter IMT değerleri ise hasta grubunda kontrol grubuna göre yüksek olmasına rağmen bu fark istatistiksel olarak anlamlı değildi. Hasta grubunda ADMA düzeyleri ile karotid IMT değerleri arasında korelasyon yoktu. Sonuç: Bizim sonuçlarımız plazma ADMA düzeylerinin romatoid artritli hastalarda daha yüksek olduğunu göstermiştir. ADMA düzeyleri ile karotid IMT değerleri ar...

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“…In the general population, carotid ultrasound has been used for cardiovascular risk stratification; Intimal-Medial Thickness (IMT) and plaque are associated with clinical CVD and have independent prognostic value for such CV events [14]. In 2 studies of Asian patients [15,16] and in a study from Poland [17], carotid IMT was increased in patients with RA compared with matched controls. In addition, patients with RA had a similar carotid IMT and prevalence of carotid plaque as with age-and gender-matched patients with type 2 diabetes mellitus.…”

Section: Subclinical Atherosclerosis Carotid Intima-media Thicknessmentioning

confidence: 99%

Atherosclerosis in Patients with Rheumatoid Arthritis

Zeng¹

2013

Rheumatology (Sunnyvale)

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Wu et al., Rheumatol Curr Res 2013, S5 http://dx.doi.org/10.4172/2161-1149 Review ArticleOpen Access AbstractBoth Rheumatoid Arthritis (RA) and atherosclerosis are complex polygenic diseases. Previous studies have demonstrated that patients with RA are associated with up to 60% increased risk of cardiovascular disease related death. Nonetheless, the increased cardiovascular morbidity and mortality in patients with RA cannot be entirely explained by traditional risk factors, and likely to be multifactorial. The present article reviews the data supporting the association of RA with cardiovascular risk factors, possible mechanism for developing atherosclerosis and evaluates the potential strategies that may prevent premature atherosclerosis in these patients.

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Elevated plasma asymmetric dimethyl‐L‐arginine levels are linked to endothelial progenitor cell depletion and carotid atherosclerosis in rheumatoid arthritis

Cited by 105 publications

References 64 publications

Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis

Asymmetric dimethylarginine and arginine levels in patients with rheumatoid arthritis

Romatoid Artritli Hastalarda ADMA Düzeyleri ile Karotid Arter Intima-Media Kalınlığı Arasındaki İlişkinin Saptanması

Atherosclerosis in Patients with Rheumatoid Arthritis

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