Elevated plasma gastrin, CEA, and CA 19-9 levels decrease after colorectal cancer resection

Bombski, Grzegorz; Gąsiorowska, Anita; Orszulak–Michalak, Daria; Neneman, Beata; Kotynia, Justyna; Strzelczyk, Janusz; Janiak, Anna; Małecka‐Panas, Ewa

doi:10.1007/s00384-002-0420-9

Cited by 18 publications

(13 citation statements)

References 29 publications

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“…2). Graphical exploration with funnel plots showed that six studies [15,22,[27][28][29]38] might have significant publication bias. After excluding these, the funnel plot was as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Helicobacter pylori infection and normal colorectal mucosa–adenomatous polyp–adenocarcinoma sequence: a meta‐analysis of 27 case–control studies

et al. 2014

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Section: Resultsmentioning

confidence: 99%

Helicobacter pylori infection and normal colorectal mucosa–adenomatous polyp–adenocarcinoma sequence: a meta‐analysis of 27 case–control studies

et al. 2014

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“…On the other hand, in a study by Orbuch et al (1996), performed similarly in patients with Zollinger-Ellison syndrome, the results showed no significant correlation between hypergastrinemia and increased risk of colorectal cancer [11]. Moreover, Bombski et al (2003) have demonstrated a decline in preoperatively elevated serum gastrin levels after curative surgical operations in colorectal cancer patients [12]. …”

Section: Discussionmentioning

confidence: 99%

Association of Helicobacter Pylori Infection and Colon Cancer

et al. 2012

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BackgroundGastrin has been shown to exert carcinogenic effect to the epithelium of the colon. This study examines whether hypergastrinemia and H. pylori infection -especially infection by the CagA+ strain- are statistically associated with colorectal cancer and examine possible correlations with the colorectal cancer stage and lymph node metastasis.MethodsIn this prospective case-control study, fasting serum samples from 93 consecutive patients with colorectal cancer treated in a university surgical clinic were preoperatively collected and serum levels of gastrin were measured. A group of 20 age matched hernia patients were used as controls. The pathology report of the specimens was documented and statistical analysis of the data where performed with the spss 17 statistical suite.ResultsH. pylori IgG antibodies was reported in 66/93 (71%) in the colorectal cancer group and 13/20 patients in the control group (65%), the difference having non-statistical significance (P = n.s). The prevalence of cagA protein expression in the anti- H. pylori IgG+ patients were higher in the colorectal cancer group (56% positivity), when compared to the control group (38,4% positivity) but the difference was not of statistical significance (P = n.s). The mean levels of serum gastrin levels in the two groups did not significantly differ (Ca group 51.1 ± 36.6 pg/mL vs Control 49.8 ± 17.6 P = n.s.). Patients with lymph node metastasis had higher serum gastrin levels than patients without metastasis and this difference was statistically significant. (53.6 vs 41.06 pg/mL P = 0.025).ConclusionsAlthough the serum gastrin levels were not statistically different between the TNM stages of our patient cohort, our data found that serum gastrin levels were significantly higher in patients with lymph node metastasis. Whether gastrin is implicated in the ability of cancer cells to metastasize to the lymph nodes merits further research.

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“…The pathomechanisms responsible for abnormal secretion of enterohormones in patients with colorectal malignancies are still unknown, and only few previous studies analyzed concentrations of these compounds in individuals with gastrointestinal tumors [26,29,36,37]. According to one hypothesis, some substances synthesized within the tumor may interact with the receptors expressed by enteroendocrine cells, which results in a decrease/increase in the synthesis of enterohormones.…”

Section: Figure 2 the Correlation Between Epigastric Bloating And Ghmentioning

confidence: 99%

“…Elevated levels of gastrin seem to be also associated with pancreatic cancer risk [21]. Bombski et al observed a significant positive correlation between plasma gastrin, CEA and colorectal cancer stage [37]. On the other hand, Selgard et al [38] and Lamberts et al [39] did not find a link between hypergastrinemia and colorectal cancer risk.…”

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Enterohormonal disturbances in colorectal cancer patients

Zygulska¹,

Furgała²,

Krzemieniecki³

et al. 2017

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Gastrointestinal (GI) hormonal peptides play a role in the development of gastrointestinal malignancies, and their abnormal levels may contribute to dysmotility. The aim of this study was to analyze plasma concentrations of enterohormones (motilin, ghrelin, gastrin and pancreatic polypeptide) and to verify if their abnormal levels may contribute to the severity of dyspeptic symptoms in colorectal cancer patients. The study included 60 patients with colorectal malignancies (22 men and 38 women), among them 30 individuals with colon cancers (group A) and 30 subjects with rectal tumors (group B). Fasting plasma levels of pancreatic polypeptide (PP), motilin, gastrin and ghrelin were determined by means of ELISA. The results were compared with the respective parameters of healthy volunteers. Colon cancer patients presented with significantly lower concentrations of ghrelin than the subjects with rectal tumors and healthy controls (156.8±86.7 vs. 260.2±87.6 vs. 258.4±94.2 pg/ml, p=0.02), as well as with significantly higher levels of PP (265.5±66.3 vs. 154.1±54.6 vs. 148.3±64.3 pg/ml, p=0.005). Also the levels of motilin turned out to be lower in colon cancer patients than in the subjects with rectal malignancies and healthy controls. No statistically significant intergroups differences were found in plasma levels of gastrin (388.2±98.6 vs. 475.6±88.7 vs. 428.2±91.2 pg/ml, p>0.05). Epigastric bloating was the most frequent dyspeptic symptom, reported by 63.3% and 40% of patients with colon and rectal tumors, respectively. Our findings imply that colon cancer patients may present with abnormal plasma levels of enterohormones significantly more often than individuals with rectal malignancies. Dysmotility observed in colon cancer patients may result not only from anticancer surgery, but also from abnormal release of enterohormones, induced either by neoplastic process or by changes within the autonomic nervous system.

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Elevated plasma gastrin, CEA, and CA 19-9 levels decrease after colorectal cancer resection

Cited by 18 publications

References 29 publications

Helicobacter pylori infection and normal colorectal mucosa–adenomatous polyp–adenocarcinoma sequence: a meta‐analysis of 27 case–control studies

Helicobacter pylori infection and normal colorectal mucosa–adenomatous polyp–adenocarcinoma sequence: a meta‐analysis of 27 case–control studies

Association of Helicobacter Pylori Infection and Colon Cancer

Enterohormonal disturbances in colorectal cancer patients

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