Elevated red cell distribution width contributes to a poor prognosis in patients with esophageal carcinoma

Wan, Guo‐Xing; Chen, Ping; Cai, Xiaojun; Li, Linjun; Yu, Xuanji; Pan, Dongdong; Wang, Xian-He; Wang, Xuan-Bin; Cao, Fengjun

doi:10.1016/j.cca.2015.11.025

Cited by 40 publications

(39 citation statements)

References 34 publications

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“…Unfortunately, only the groups of Sun P. and Chen GP., determined the optimal cut-off value for RDW by receiver operating characteristic (ROC) curves (34,38) while the In univariate analyses RDW always emerged as significant risk factors for a poor prognosis with HR ranging from 1.381 to 3.087 for OS and from 1.719 to 2.332 for CSS. Wan et al (35) and Zhang et al (37) also found a significant association between high RDW and shorter DFS (HR, 3.208; 95% CI, 1.922−5.353; P<0.0001 and 1.474; 95% CI, 1.046−2.077; P=0.027 respectively). Moreover, the results of the multivariate analyses overall qualified RDW as independently predictor of patient OS or cancer specific survival (CCS) survival.…”

Section: Role Of Rdw In Solid Cancersmentioning

confidence: 85%

“…To date, five studies have investigated the prognostic value of RDW in esophageal cancer (34)(35)(36)(37)(38). The study characteristics and the main findings of these studies are reported in Table 2.…”

Section: Role Of Rdw In Solid Cancersmentioning

confidence: 99%

“…Four out of five studies enrolled patients affected by esophageal squamous cell carcinoma (ESCC). The remaining one included patients with either squamous or adenocarcinoma subtype (35). All studies applied similar cut-off values ranging from 12.2% to 15.3% for dividing patients in high and low RDW categories.…”

Section: Role Of Rdw In Solid Cancersmentioning

confidence: 99%

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Red cell distribution width and cancer

2016

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Red cell distribution width (RDW) is an index which primarily reflects impaired erythropoiesis and abnormal red blood cell survival. In last years the interest in this marker has considerably grown and now a lot of data are available indicating that this simple and inexpensive parameter is a strong and independent risk factor for death in the general population. Moreover, several investigations have been performed to investigate the role of RDW in cardiovascular and thrombotic disorders. Contrarily, there are relatively few reports focusing on RDW in the area of oncology and to date none review have been performed in this specific field. As such, the aim of this narrative review is to summarize some interesting results obtained in studies performed in patients affected by solid and hematological tumors. Even if larger studies are needed before these preliminary findings can be generalized, it seems plausible to affirm that RDW can be useful by adding prognostic information in patients with oncologic disease.

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Section: Role Of Rdw In Solid Cancersmentioning

confidence: 85%

Section: Role Of Rdw In Solid Cancersmentioning

confidence: 99%

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Red cell distribution width and cancer

2016

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“…Lee et al reported that high RDW at diagnosis was a worse prognostic factor for progression-free survival in symptomatic multiple myeloma patients [10]. Wan et al found that high RDW was associated with poor prognosis in esophageal carcinoma patients [11]. Koma et al reported that high values of RDW were associated with worse survival in patients with lung cancer [12].…”

Section: Discussionmentioning

confidence: 99%

Significance of Pretreatment Red Blood Cell Distribution Width in Patients with Newly Diagnosed Glioblastoma

Liang

Yang

et al. 2017

Med Sci Monit

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BackgroundRed blood cell distribution width (RDW) is a parameter of the complete blood count (CBC) test. Recent evidence suggests that pretreatment RDW is associated with patient survival in various malignant tumors. We explored the association of pretreatment RDW and other red blood cell (RBC) parameters with clinical parameters and assessed their prognostic impact on overall survival (OS) in patients with glioblastoma (GBM).Material/MethodsIn total, 109 patients with newly diagnosed GBM were retrospectively reviewed. The Cox proportional hazards regression model and Kaplan-Meier method were used to examine the survival function of pretreatment RDW, mean cell volume (MCV), hemoglobin (HGB), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), RBC count, and hematocrit (HCT) values in patients with newly diagnosed GBM.ResultsUnivariate analysis showed that MCV, MCHC, and RDW were associated with overall survival (OS). However, only RDW remained significant in multivariate analysis. The Kaplan-Meier survival curves showed that patients belonging to the high-RDW group had a worse median OS (293 days versus 375 days, P=0.023) than those belonging to the low-RDW group.ConclusionsThe present study showed that pretreatment RDW was superior to MCV and MCHC as a prognostic predictor of clinical outcome in patients newly diagnosed with GBM. Pretreatment RDW was derived directly from the CBC test, which can be easily performed in clinical practice. Therefore, pretreatment RDW values can provide additional prognostic information for patients with GBM. Further larger and prospective studies are needed to confirm these findings and to investigate the mechanism by which of RDW is associated with prognosis in patients with GBM.

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“…In addition, baseline Hb levels correlate with outcomes of radiotherapy in patients suffering cancer, such as cervix[8], prostate[9], head and neck[10]. Red cell distribution width (RDW), which is a quantitative measurement of the variation of circulating red blood cell size, might be served as a convenient marker to predict the mortality risk of patients with lung cancer[11], endometrial cancer[12] and esophageal cancer[13]. Recently, a research indicates that anemia pretreatment in breast cancer patients might deteriorate the pathological response to neoadjuvant chemotherapy as well as survival status[14].…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Hematocrit Is Superior to Hemoglobin as a Prognostic Factor for Triple Negative Breast Cancer

et al. 2016

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BackgroundAnemia usually refers to low hemoglobin (Hb) levels. Previous studies indicated that anemia negatively influence the survival in various cancers. Hematocrit (HCT) is the volume percentage of red blood cells in blood, which could indicate anemia in both individuals and populations. This study compared the value of HCT with that of Hb for predicting outcomes of patients who underwent treatment for triple negative breast cancer (TNBC).MethodsA retrospective study of 293 triple negative breast cancer patients, accepting treatment from January 2004 to December 2009 at Sun Yat-sen University Cancer Center, was conducted. Kaplan-Meier curves and multivariate Cox proportional models were used to calculate disease free survival (DFS) and overall survival (OS).ResultsThe cut-off value of HCT was 35.9% determined by X-tile software analysis. The cut-off value of Hb was 12.0 g/dl based on the World Health Organization (WHO) criteria. In univariate analysis, low HCT and low Hb were both significantly associated with decreased DFS and OS. In multivariate analysis, HCT (HR: 0.570; 95% CI: 0.331–0.981, P = 0.042 for DFS; HR: 0.456; 95% CI: 0.256–0.813, P = 0.008 for OS) was still identified as independent predictor of outcome, but not Hb.ConclusionPretreatment low HCT is independently associated with poor prognosis in TNBC patients. However, HCT was found to be superior to Hb in terms of predicting breast cancer mortality. In the future, large-scale prospective studies or validation studies are needed to verify our findings.

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Elevated red cell distribution width contributes to a poor prognosis in patients with esophageal carcinoma

Cited by 40 publications

References 34 publications

Red cell distribution width and cancer

Red cell distribution width and cancer

Significance of Pretreatment Red Blood Cell Distribution Width in Patients with Newly Diagnosed Glioblastoma

Pretreatment Hematocrit Is Superior to Hemoglobin as a Prognostic Factor for Triple Negative Breast Cancer

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