Elevated serum B-cell activating factor in patients with chronic urticaria

Kessel, Aharon; Yaacoby-Bianu, Karin; Vadasz, Zahava; Peri, Regina; Halazs, Katy; Toubi, Elias

doi:10.1016/j.humimm.2012.03.016

Cited by 18 publications

(7 citation statements)

References 17 publications

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“…Other inflammatory markers that have been claimed to be elevated and linked to disease activity include IL‐6, IL‐18, complements C3 and C4, vascular endothelial growth factor (VEGF), B‐cell‐activating factor (BAFF) and matrix metalloproteinase‐9 (MMP‐9) . Few studies have tried to correlate the blood levels of inflammatory parameters with the clinical activity in CU.…”

Section: Resultsmentioning

confidence: 99%

“…For example, C-reactive protein (CRP) is increased in patients with CSU, especially in patients with positive ASST, and increased CRP levels reportedly correlate with disease activity. [62][63][64][65][66] Other inflammatory markers that have been claimed to be elevated and linked to disease activity include IL-6, 65 IL-18, 66 complements C3 and C4, 67 vascular endothelial growth factor (VEGF), 68 B-cell-activating factor (BAFF) 69 and matrix metalloproteinase-9 (MMP-9). 66,70 Few studies have tried to correlate the blood levels of inflammatory parameters with the clinical activity in CU.…”

Section: Laboratory Markers Of Severity and Prognosismentioning

confidence: 99%

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Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Sánchez‐Borges

Caballero‐Fonseca

Capriles‐Hulett

et al. 2017

Acad Dermatol Venereol

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Biomarkers useful for the evaluation and management of patients with chronic spontaneous urticaria (CSU) are not currently available. A review of various clinical and laboratory markers that have been studied to assess their value for determining the severity or predicting the evolution of disease in adult patients with CSU was carried out. A search of the medical literature on PubMed and MEDLINE including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, CSU, severity, prognosis and treatment was performed. Based on our review of the literature, among the clinical markers studied, higher age at onset, being female, long disease duration and aspirin/NSAID hypersensitivity may be linked to both severe CSU and a long time to spontaneous remission. In addition, a positive autologous serum skin test (ASST) may be associated with severe CSU, and comorbidity of inducible urticaria and concomitant recurrent angio-oedema may be linked to longer CSU duration. Potential biomarkers of CSU severity and/or duration include basophil numbers and susceptibility to activation, inflammatory markers, markers of activation of the extrinsic coagulation pathway, immunoglobulin E and vitamin D. Although the described markers are promising, further studies on representative and well-characterized patient populations are needed to determine the value of these clinical and biological markers for predicting the severity and course of disease in patients with CSU.

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Section: Resultsmentioning

confidence: 99%

Section: Laboratory Markers Of Severity and Prognosismentioning

confidence: 99%

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Sánchez‐Borges

Caballero‐Fonseca

Capriles‐Hulett

et al. 2017

Acad Dermatol Venereol

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“…They differ in their mast cell-activating triggers, but are similar in that histamine and other inflammatory mast cell mediators are involved in their pathogenesis. Both disorders include the involvement of cytokines/mediators such as IL-4, IL10, IL-33 and B cell-activating factor (BAFF) - all of which contribute to the activation of many immune cells and the influx of leukocytes to the dermis and airways [1,2,3]. In both conditions, IgE is frequently elevated and anti-IgE therapy is highly effective.…”

Section: Introductionmentioning

confidence: 99%

Seasonal Exacerbation of Asthma Is Frequently Associated with Recurrent Episodes of Acute Urticaria

Vadasz

Kessel

Hershko

et al. 2016

Int Arch Allergy Immunol

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Background: Asthma and urticaria are both partially mediated by an increased release of histamine from highly activated mast cells. They are pathophysiologically different, as mast cell degranulation in these 2 disorders results from different mechanisms. Objective: To assess the incidence of urticaria in patients with asthma, and of asthma in patients with chronic spontaneous urticaria (CSU). Patients and Methods: Over 1 year of follow-up, asthma patients (n = 110) were assessed for the incidence and characteristics of urticaria, and a link, if it existed, to seasonal exacerbations and the severity of asthma was traced. We also prospectively assessed CSU patients (n = 95) during the same period of time for the incidence of asthma. Healthy individuals (n = 100), serving as a control group, were also assessed. Results: Episodes of urticaria occurred in 26/110 asthma patients (23.6%), but in only 2/100 healthy control subjects (2%) (p < 0.0001). During the 1-year observation period, episodes of urticaria were significantly more frequent in asthma patients with positive skin-prick test reactions (mainly seasonal pollens), and consequently occurred mostly during seasonal asthma exacerbation, i.e. during acute episodes of urticaria. The incidence of asthma in CSU patients was recorded in 10.5% of the group, similar to that in the healthy control population. Discussion: Our study demonstrates, for the first time, that asthma patients frequently develop acute urticaria, mainly during seasonal exacerbations. In contrast, CSU patients do not show an increased incidence of asthma.

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“…Although the pathophysiology is different in asthma and urticaria, they are similar in terms of the histamine and inflammatory mast cell mediators released (such as interleukin IL-4, IL-10, IL-33 and B cell-activating factor). [26][27][28] Some studies have shown that asthma and urticaria are related and that asthma is common in patients with chronic spontaneous urticaria. 29,30 According to previous studies, 4,13 the IV seldomly causes extensive cutaneous or chronic adverse effects.…”

Section: Discussionmentioning

confidence: 99%

<p>Risk Of Urticaria In Geriatric Stroke Patients Who Received Influenza Vaccination: A Retrospective Cohort Study</p>

Lam

Shih

Chen

et al. 2019

CIA

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Urticaria is a mast cell-related disease caused severe itching and the lifetime prevalence of urticaria is about 20% in general population. Our purpose is to evaluate risk of urticaria in geriatric stroke patients received influenza vaccination (IV). Methods: In a cohort of 192,728 patients with newly diagnosed stroke aged over 65 years obtained from 23 million people in Taiwan's National Health Insurance between 2000 and 2008, we identified 9890 stroke patients who received IV and 9890 propensity score-matched stroke patients who did not receive IV. Controlling for immortal time bias, both the IV and non-IV groups were followed for one year. Urticaria events were identified during the follow-up period. We calculated the adjusted rate ratios (RRs) and 95% confidence intervals (CIs) of the one-year risk of urticaria associated with IV. Results: During the follow-up period of one year, stroke patients with IV had a significantly higher risk of urticaria compared with non-IV stroke patients (RR 1.81, 95% CI 1.47-2.23). An increased risk of urticaria in stroke patients with IV was noted in both sexes, patients 65-84 years of age, patients with comorbid medical conditions, and various time intervals of follow-up. Vaccinated stroke patients with hemorrhage (RR 4.00, 95% CI 1.76-9.10) and those who received intensive care (RR 5.14, 95% CI 2.32-11.4) had a very high risk of urticaria compared with those without IV. Conclusion: Receiving IV may be associated with an increased risk of urticaria in stroke patients. We could not infer the causality from the current results because of this study's limitations. Future investigations are needed to evaluate the possible mechanism underlying the association between IV and urticaria.

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Elevated serum B-cell activating factor in patients with chronic urticaria

Cited by 18 publications

References 17 publications

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria

Seasonal Exacerbation of Asthma Is Frequently Associated with Recurrent Episodes of Acute Urticaria

<p>Risk Of Urticaria In Geriatric Stroke Patients Who Received Influenza Vaccination: A Retrospective Cohort Study</p>

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