Elevation of creatine kinase in acute pancreatitis: A case report

Sheibani, Mehdi; Hajibaratali, Bahareh; Yeganegi, Houra

doi:10.1002/ccr3.5309

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…An increase in CK can be seen in SAP, which may be a predictive factor for SAP. 42 In our research, several scores including Ranson, BISAP and SOFA were compared with our nomogram, which showed that the predictive performance of the nomogram model in our study was the best. Previous research showed that Ranson, BISAP and SOFA scores have been applied widely for evaluating the disease severity in AP.…”

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confidence: 67%

Establishment and Validation of an Early Predictive Model for Severe Acute Pancreatitis

Yang,

Song,

et al. 2024

JIR

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The purpose of this study is to establishment and validation of an early predictive model for severe acute pancreatitis (SAP). Methods: From January 2015 to August 2022, 2986 AP patients admitted to Changsha Central Hospital were enrolled in this study. They were randomly divided into a modeling group (n = 2112) and a validation group (n = 874). In the modeling group, identify risk factors through logistic regression models and draw column charts. Use internal validation method to verify the accuracy of column chart prediction. Apply calibration curves to evaluate the consistency between nomograms and ideal observations. Draw a DCA curve to evaluate the net benefits of the prediction model. Results: Nine variables including respiratory rate, heart rate, WBC, PDW, PT, SCR, AMY, CK, and TG are the risk factors for SAP. The column chart risk prediction model which was constructed based on these 9 independent factors has high prediction accuracy (modeling group AUC = 0.788, validation group AUC = 7.789). The calibration curve analysis shows that the prediction probabilities of the modeling and validation groups are consistent with the observation probabilities. By drawing a DCA curve, it shows that the model has a wide threshold range (0.01-0.88). Conclusion:The study developed an intuitive nomogram containing readily available laboratory parameters to predict the incidence rate of SAP.

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confidence: 67%

Establishment and Validation of an Early Predictive Model for Severe Acute Pancreatitis

Yang,

Song,

et al. 2024

JIR

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“…Previously only several case reports considered the potential role of CK in AP development. In 2022, Sheibani et al described a case of a 39-year-old man with AP where the CK activity peaked the day after admission but returned to normal 5 days after the admission ( 22 ). Karachaliou et al described a case report of a 64-year-old woman whose increased CK levels normalized throughout hospitalization in total of 12 days ( 23 ).…”

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confidence: 99%

Diagnostic Potential of Ratio Between Creatine Kinase and Amylase in Acute Pancreatitis

Selimovic,

Jahic,

Kurtovic

et al. 2023

Mater Sociomed

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Background: Acute pancreatitis (AP) is an acute inflammatory illness of the pancreas representing a true question in diagnostic process. Laboratory markers of the hepatobiliary tract such as liver transaminases with pancreatic enzymes give a true hint of a hidden diagnosis together with urea, creatinine and creatine kinase (CK). Objective: This clinical study aims to show whether there is any correlation between alpha-amylase and CK or their ratio examining hospitalized patients with AP diagnosis. Methods: From total number of 99 patients with a clinical picture of AP, 71 patients in this retrospective analysis (including both genders) were included according to the presence of two biochemical markers in collected laboratory analysis at admission and 72 hours later on a laboratory check-up: CK and alpha-amylase. Results: The median CK value of AP cases was 92 (41.75 – 207.25) in the acute period and 73 (37 – 159) after 72h staying in the hospital without statistical significant (p=0.521; p<0.05). However, there was a statistically significant correlation between the parameters of CK at admission and creatine kinase after 72h staying in the hospital. The median value of CK/Amylase ratio in the acute period was 0.168 (0.069 – 0.532) and 0.386 (0.12 – 1.12) after 72 hours of staying in the hospital. There was a statistically significant difference between values of CK/amylase ratio in these two groups (p=0.000; p<0.01). Conclusion: In conclusion, a connection between CK and alpha-amylase needs to be elucidated in further studies and its existence must be researched both in physiological and pathophysiological conditions, and it is two-way and very complex. This study helped us obtain significant information about the perspective of AP in the potential relation to other non-standard laboratory markers for some diseases

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The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases

Pan

Yang

et al. 2023

Clinica Chimica Acta

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Elevation of creatine kinase in acute pancreatitis: A case report

Cited by 3 publications

References 14 publications

Establishment and Validation of an Early Predictive Model for Severe Acute Pancreatitis

Establishment and Validation of an Early Predictive Model for Severe Acute Pancreatitis

Diagnostic Potential of Ratio Between Creatine Kinase and Amylase in Acute Pancreatitis

The liver and blood cells are responsible for creatine kinase clearance in blood Circulation: A retrospective study among different human diseases

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