Elimination of ketoprofen from the stratum corneum after topical administration with ketoprofen formulations in human subjects

Takeshi, Masahiko; Ebihara, Tamotsu; Maekawa, Kotaro; Yamamoto, Kaori; Higo, Naruhito

doi:10.1016/j.ijpharm.2014.02.015

Cited by 7 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drug has a half‐life of 2 h, resulting in multiple dosage regimens. The main undesirable side effects include gastrointestinal adverse reactions (ulcerations, abdominal burning, and even gastrointestinal bleeding), renal and hepatic toxicity . In addition, no significant differences have been observed in the percutaneous absorption of ketoprofen, allowing a focal release of the drug and sustained plasma concentration .…”

Section: Introductionmentioning

confidence: 99%

Characterization of ketoprofen‐loaded PEG‐CH semi‐IPN system for wound dressing application

Gaitán-Tolosa

Montiel-Campos

Flores-Estrada

et al. 2018

J of Applied Polymer Sci

View full text Add to dashboard Cite

Polymer systems, in the form of crosslinking networks, have been widely used in biomedicine. However, they are a challenge mainly due to the impact of their physicochemical properties on release kinetics of drugs. Ketoprofen is an analgesic anti‐inflammatory drug with short half‐life (<2 h) and quickly eliminated by the body. Topical administration of ketoprofen can reduce pain, accelerate the wound healing process, and minimize the risk of systemic side effects. Therefore, the aim was to synthesize, characterize, and evaluate a novel ketoprofen polymer system in the form of a semi‐interpenetrated network of poly(ethylene glycol)‐chitosan. The pore size studied by small‐angle X‐ray scattering showed the presence of nanoscale pores, 13.7 nm (dry state) and 26.18 nm (swollen form). The maximum swelling was 420 ± 45% at 24 h. Finally, the encapsulated ketoprofen (6.5%) was released at a constant concentration (0.12 ± 0.03 mg/mL, 8 h) and half of the doses up to 24 h. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46644.

show abstract

Section: Introductionmentioning

confidence: 99%