Elucidation of Structure Function Relationships in the IL-8 Family by X-ray Crystallography

Auer, Manfred; Owens, Susan R; Pfeffer, Sabine; Kallen, Joerg; Wasserbauer, Erich; Aschauer, H; Ehn, Gerald; Rot, Antal; Besemer, J; Lam, Charles; Lindley, I. J. D.

doi:10.1007/978-1-4615-2952-1_18

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“…leukotrienes; Scheja and Forsgren, ). The specificity of chemoattraction is based on the extremely high molecular discriminatory capacity of the responsible receptor complexes as demonstrated by variable effects of molecules like chemokines (IL‐8 and derivatives; Auer et al ., ) or bacterial peptides (fMXXX family; Freer et al ., ). However, not only the sequence but also the physicochemical properties (p K , hydrophobicity, residual volumes, etc.)…”

Section: Introductionmentioning

confidence: 99%

Chemotaxis induced by SXWS tetrapeptides in Tetrahymena—overlapping chemotactic effects of SXWS sequences and their identical amino acids

Láng

Illyés

Menyhárd

et al. 2011

J of Molecular Recognition

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The chemotactic potential of SXWS peptides and the components of the extracellular domain of cytokine receptors were investigated in Tetrahymena as a functional index of substitution with different amino acids in the position 'X' of the tetrapeptide. Data obtained demonstrate that position X plays a special determining role in the ligand, SEWS and STWS possess extremely strong chemoattractant ability, and aromatic amino acids result in chemorepellent ligands. Diverse effects of structurally related molecules, for example, SNWS-SDWS, demonstrate a highly sensitive discrimination potential in the applied model system. Physicochemical characteristics (hydropathy, residue size, and solvent-exposed area) of the amino acids were correlated with the chemotactic activity. Data obtained by computer-assisted conformation analysis of SXWS peptides and the highly overlapping chemotactic effects of the investigated SXWS peptides as well as the presence of the amino acids in the 'X' position indicate that member 'X' of the SXWS sequence performs a special role in interactions with the chemotaxis receptors in the membrane.

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Section: Introductionmentioning

confidence: 99%