Emblica officinalis (Linn.) Fruit Extract Provides Protection against Radiation-Induced Hematological and Biochemical Alterations in Mice

Singh, Inder; Soyal, Dhanraj; Goyal, Pradeep

doi:10.1615/jenvironpatholtoxicoloncol.v25.i4.40

Cited by 19 publications

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“…Emblica officinalis L. (Phyllanthaceae), which is known as Indian Gooseberry or Amla, is a fruit that has high levels of ascorbic acid (from 1100 to 1700 mg/100 g of fruit extract) and a high density of ellagitannins including emblicanin A (37%) ( Figure 8 ), emblicanin B (33%), punigluconin (12%), and pedunculagin. Amla is often consumed as a functional food due to its physiological features, such as radioprotection [ 173 , 174 , 175 ], antioxidant activity [ 176 , 177 , 178 , 179 , 180 ], hepatoprotection [ 181 , 182 , 183 , 184 ], cytoprotection [ 185 , 186 ], and hypolipidemic effects [ 176 , 187 , 188 , 189 ]. In a recent double-blind RCT, 98 patients affected with dyslipidemia were asked to either consume 500 mg capsule of Amla extract (from Indian gooseberry) each day or placebo for 12 weeks.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

et al. 2021

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Background: Among non-communicable diseases, cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity in global communities. By 2030, CVD-related deaths are projected to reach a global rise of 25 million. Obesity, smoking, alcohol, hyperlipidemia, hypertension, and hyperhomocysteinemia are several known risk factors for CVDs. Elevated homocysteine is tightly related to CVDs through multiple mechanisms, including inflammation of the vascular endothelium. The strategies for appropriate management of CVDs are constantly evolving; medicinal plants have received remarkable attention in recent researches, since these natural products have promising effects on the prevention and treatment of various chronic diseases. The effects of nutraceuticals and herbal products on CVD/dyslipidemia have been previously studied. However, to our knowledge, the association between herbal bioactive compounds and homocysteine has not been reviewed in details. Thus, the main objective of this study is to review the efficacy of bioactive natural compounds on homocysteine levels according to clinical trials and animal studies. Results: Based on animal studies, black and green tea, cinnamon, resveratrol, curcumin, garlic extract, ginger, and soy significantly reduced the homocysteine levels. According to the clinical trials, curcumin and resveratrol showed favorable effects on serum homocysteine. In conclusion, this review highlighted the beneficial effects of medicinal plants as natural, inexpensive, and accessible agents on homocysteine levels based on animal studies. Nevertheless, the results of the clinical trials were not uniform, suggesting that more well-designed trials are warranted.

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Section: Resultsmentioning

confidence: 99%

The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

et al. 2021

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“…Only 11% mortality was evident in PGE-pretreated irradiated animals treated with 25 mg/kg body weight per day of PGE in the present experiment. Similarly, plants such as Alstonia scholaris, 35 Trigonella foenum greacum, 36 Emblica officinalis, 37 and Rosemarinus officinals 38 have also been reported to provide protection in a similar fashion against sickness induced by radiation.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract

et al. 2010

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Background. This study was carried out to observe the radioprotective effect of Panax ginseng root extract (PGE) against radiation-induced hematological and biochemical alterations in blood and liver of mice. Materials and methods. Adult Swiss albino mice were exposed to 6 Gy gamma radiation in the presence (experimental) or absence (control) of PGE to study the quantitative and qualitative alterations in the blood and liver. Results. Radiation exposure resulted in a significant decline (P < .001) in erythrocyte count, hemoglobin (Hb), and hematocrit (Hct) in peripheral blood. Maximum changes in all the parameters were observed on day 3 after irradiation. In contrast, PGE-pretreated irradiated animals showed a significant increase in erythrocyte, Hct, and Hb values compared with irradiated controls. Furthermore, a significant elevation in lipid peroxidation level over normal was recorded in irradiated control mice, whereas this increase was considerably lesser in PGE pretreated animals. Likewise, pretreatment with PGE caused a significant increase in glutathione levels in serum as well as in liver in comparison to irradiated controls. Conclusion. From this study, it is clearly evident that PGE provides protection against radiation-induced hematological and biochemical alterations in Swiss albino mice.

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“…Active extracts of PE have been shown to posses anticancer [14,15], radioprotection [16], anti-inflammatory [17] and antioxidant [18,19] properties in several models of organ injury.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury

Tasanarong

Kongkham

Itharat

2014

BMC Complement Altern Med

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BackgroundContrast-induced acute kidney injury (CI-AKI) occurs after the administration of intravenous iodinated contrast agents. Oxidative stress has been proposed as one of the most important mechanisms in the pathogenesis of CI-AKI. The objective of this study was to investigate the antioxidant effect of the extract from Phyllanthus emblica (PE) in preventing CI-AKI.MethodsMale Sprague Dawley rats were subjected into eight groups, were given water (control) or PE extract (125 or 250 or 500 mg/kg/day) for 5 days before the induction of CI-AKI. Renal function and oxidative stress markers; malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD) and catalase (CAT) activity were determined in plasma and renal tissue. Kidney sections were performed for histopathological examination.ResultsIn the contrast media (CM) group, increases in blood urea nitrogen and serum creatinine were demonstrated which correlated with severity of tubular necrosis, peritubular capillary congestion and interstitial edema. Moreover, an increase in MDA and a decrease in TAC SOD and CAT activity in CM group were significantly changed when compared with the control (P < 0.05). In contrast, CI-AKI-induced rats administrated with PE extract 250 and 500 mg/kg/day significantly preserved renal function and attenuated the severity of pathological damage (P < 0.05) as well as significantly lower MDA and higher TAC, SOD and CAT than the CM group (P < 0.05).ConclusionsThis study demonstrated the protective role of PE extract against CI-AKI.

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Emblica officinalis (Linn.) Fruit Extract Provides Protection against Radiation-Induced Hematological and Biochemical Alterations in Mice

Cited by 19 publications

References 0 publications

The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

Amelioration of Radiation-Induced Hematological and Biochemical Alterations in Swiss Albino Mice by Panax ginseng Extract

Antioxidant effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury

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