Embryonal rhabdomyosarcoma (sarcoma botryoides) of the cervix presenting as a cervical polyp treated with fertility-sparing surgery and adjuvant chemotherapy

Bernal, Kerry; Fahmy, Lylia; Remmenga, Steven W.; Bridge, Julia A.; Baker, John J.

doi:10.1016/j.ygyno.2004.06.049

Cited by 46 publications

(42 citation statements)

References 9 publications

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“…4 Several other lesions enter into the pathologic differential diagnosis, including adenosarcoma, rhabdomyoma, edematous cervical mesodermal polyps (pseudosarcoma botryoides), and other "small, round, blue cell" tumours. 6 Adenosarcomas, a strong option that was considered in our case as a differential diagnosis, can also be found in young female, but histologically can be distinguished from sarcoma botryoides by their fibrous stroma and leaf-like pattern of glands. Also, immunohistochemical markers that usually label ERMS are desmin, with a positivity rate of 75-100%, vimentin and myogenin, which is considered the most sensible and specific marker (70-100% of cases).…”

Section: Gomes Ar Et Al Int J Reprod Contracept Obstet Gynecol 2017mentioning

confidence: 78%

“…Also, immunohistochemical markers that usually label ERMS are desmin, with a positivity rate of 75-100%, vimentin and myogenin, which is considered the most sensible and specific marker (70-100% of cases). 4,6 Before 1970, radical surgery was considered the gold standard. However, after consecutive trials, the IRSG has modified the treatment protocols with the addition of multiple chemotherapeutic agents to surgery, greatly improving the prognosis and survival of thistumour and also allowed more conservative fertility-sparing surgeries in early stages of the disease.…”

Section: Gomes Ar Et Al Int J Reprod Contracept Obstet Gynecol 2017mentioning

confidence: 99%

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Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Gomes

Leite

Rocha

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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Embryonal rhabdomyosarcoma of the female genital tract is a rare tumour. It tends to occur during childhood in the vagina and, rarely, it can arise in the uterine cervix, with a peak incidence in the second decade. We report a case of a 18-year-old female with an embryonal rhabdomyosarcoma (sarcoma botryoides) presenting himself as a cervical polyp. This tumour consisted of rhabdomyoblasts with miscellaneous differentiation surrounded by a loose, myxoid stroma. The patient was successfully treated with cervical conization and adjuvant chemotherapy. She is now disease-free at the 28th month follow-up. Awareness of this uncommon lesion in the cervix and its clinical implications is important to prevent misdiagnosis. Therapy has recently inclined to conservative and fertility-sparing treatment.

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Section: Gomes Ar Et Al Int J Reprod Contracept Obstet Gynecol 2017mentioning

confidence: 78%

Section: Gomes Ar Et Al Int J Reprod Contracept Obstet Gynecol 2017mentioning

confidence: 99%

Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Gomes

Leite

Rocha

et al. 2016

Int J Reprod Contracept Obstet Gynecol

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“…Beneath intact epithelium condensed sub epithelial layer of rhabdomyoblasts are scattered in a loose myxoid or dense collagen..The cells in cambium layer are round to spindle with oval nuclei with open chromatin and inconspicuous nuclei. The pathological differential diagnosis of this lesion includes rhabdomyoma, edematous cervical mesodermal polyps (pseudo sarcoma botryoides) and adeno sarcoma [7] Mesoderm stromal polyp (pseudo sarcoma botryoides) is benign exophytic lesion occurring in the vagina and cervix of women of reproductive age. Histology shows the polypoidal lesion composed of edematous stroma covered by a benign appearing stratified squamous epithelium.…”

Section: Discussionmentioning

confidence: 99%

“…It can be differentiated from embryonal rhabdomyosarcoma by the absence of cambium layer and mitotic figures. Sarcoma botryoides of the cervix behaves less aggressively than sarcoma botryoides of the vagina and uterus [7]. Recently the approach of management of embryonic rhabdomyo sarcoma has been increasingly conservative in order to preserve the fertility in young nulliparous women [3,8].…”

Section: Discussionmentioning

confidence: 99%

Botryoid rhabdomyosarcoma of cervix - A Rare case report

Rao¹

2017

NMJ

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“…Asociada a la cirugía y la radioterapia en casos seleccionados, la tasa de supervivencia libre de enfermedad y global se ha incrementado hasta el 70% a los 5 años y el 90% en enfermedad no metastásica. En las mujeres adultas este porcentaje es más variable y no tan optimista; ronda el 60-70% en pacientes del grupo I y subtipo embrionario, descendiendo al 30% en enfermedad muy voluminosa, diseminada, o histológicamente más agresiva (1)(2)(3)(4)9).…”

Section: Discussionunclassified

Rabdomiosarcoma embrionario de cérvix uterino en mujer adulta

et al. 2012

Rev. chil. obstet. ginecol.

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RESUMENEl rabdomiosarcoma (RMS) del tracto genital inferior es una patología maligna relativamente frecuente en la infancia aunque muy poco prevalente en la edad adulta. Tan solo suponen el 2-4% de todos los sarcomas de partes blandas. Se trata de una neoplasia derivada de células progenitoras de miocitos de músculo estriado en distinto grado de diferenciación. En un elevado número de casos, el cuadro se presenta como un pólipo endocervical de apariencia benigna, lo cual retrasa el diagnóstico. El correcto manejo del RMS de tracto genital es controvertido. Un esquema agresivo de tratamiento con cirugía, poliquimioterapia y radioterapia en pacientes seleccionadas, ha demostrado aumentar la supervivencia e incluso conseguir la curación en estadios precoces.KEY WORDS: Rabdomiosarcoma embrionario, cuello uterino, tracto genital, mujer adulta SUMMARY Rhabdomyosarcoma (RMS) of the lower genital tract is a common childhood malignancy but a rare tumor in female adults. It accounting for around 2-4% of soft-tissue sarcomas. It is a malignant neoplasm originating from myogenic progenitors cells that shows variable stages of skeletal muscle differentiation. In many cases, the tumor appears as a benign endocervical polyp and this delays the correct diagnosis. Optimal management of adult genital tract RMS is uncertain. Aggressive primary therapy with local excition, polichemotherapy and radiotherapy in selected patients may result in prolonged survival and cure in early stages. KEY WORDS: Embryonal rhabdomyosarcoma, uterine cervix, gynecologic tract, female adult INTRODUCCIÓNEl rabdomiosarcoma (RMS) es una neoformación maligna derivada de células mesenquimales precursoras de los miocitos (1). Constituye el 6-8% de las neoplasias sólidas en la edad pediátrica, apareciendo como el tumor maligno de partes blandas más prevalente. Sin embargo, en la edad adulta, supone menos del 4% de los sarcomas, siendo muy poco habitual la localización genital (2,3).Según el Intergroup Rhabdomyosarcoma Study (IRS) la máxima incidencia del rabdomiosarcoma embrionario genital se registra en menores de catorce años, cuya ubicación típica es la vagina. La localización cervical, cuatro veces menos frecuente, es propia de adolescentes y adultas jóvenes, mientras que la corporal lo es de mujeres postmenopáusicas (2-4). Histológicamente los RMS se

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Embryonal rhabdomyosarcoma (sarcoma botryoides) of the cervix presenting as a cervical polyp treated with fertility-sparing surgery and adjuvant chemotherapy

Cited by 46 publications

References 9 publications

Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Embryonal rhabdomyosarcoma of the uterine cervix: a rare case report

Botryoid rhabdomyosarcoma of cervix - A Rare case report

Rabdomiosarcoma embrionario de cérvix uterino en mujer adulta

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