Emergence of a Unique Multiply-Antibiotic-Resistant
            <i>Streptococcus pneumoniae</i>
            Serotype 7B Clone in Dhaka, Bangladesh

Rahman, Mahbubur; Hossain, Shahadat; Shoma, Shereen; Rashid, Harunur; Baqui, Abdullah H; Linden, Mark van der; Al‐Lahham, Adnan; Reinert, Ralf René

doi:10.1128/jcm.01740-06

Cited by 6 publications

(1 citation statement)

References 17 publications

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“…Multi drug resistant to B-lactamase, Macrolides and Fluroquinolone is an emerging problem and complicating the management of CAP 20 . In a study ICDDRB Rahman et al 21 found Pneumococcus serotype is resistant to penicillin and macrolides posing threat to Bangladesh and some other Asian countries. Saibal 18 showed the sensitivity pattern against the Streptococcus pneumoniae to Amoxyclav 83%, and Klebsiella pneumoniae to Ceftriaxone 73.3% which is comparable with the present study.…”

Section: Discussionmentioning

confidence: 99%

Clinical Presentation and Bacterial Etiology of Adult Community Acquired Pneumonia

Salam¹,

Amin

Islam³

2017

J. Bangladesh Coll. Phys.

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Introduction: Pneumonia is a worldwide, serious threat to health and an enormous socio-economic burden for health care system. According to recent WHO data, each year 3-4 million patients die from pneumonia. The clinical presentations and bacterial agents responsible for community acquired pneumonia (CAP) varies according to geography and culture.Methods: A cross sectional observational study conducted among the 53 consecutive patients with a clinical diagnosis of CAP in admitted patient in the department of Medicine, DMCH, during January 2010 to December 2010. Hematological measurements (TC of WBC, Hb%, ESR, platelet count), blood culture, chest X-ray P/A view, sputum for Gram staining and culture sensitivity, sputum for AFB, blood urea and random blood sugar were done in all cases. ELISA for IgM antibody of Mycoplasma pneumoniae and Chlamydia pneumoniae were done in sputum culture negative cases.Results: The mean (±SD) age was 38.9±17.3 years and Male female ratio was 3:1. Fever, chest pain and productive cough were the most common clinical features. The mean (±SD) respiratory rate was 23.0±2.8 /minute . COPD and DM were found in 17.0% and 5.7% of patients respectively . Blood culture was found positive in only 1.9% of the study patients. Gram positive Cocci 62.26%, Gram negative Bacilli 9.43%, mixed Gram positive cocci and Gram negative bacilli 11.32% and Gram negative Cocco Bacilli 1.9% were observed and in 15.03 % cases, no bacteria could be seen. Sputum culture revealed 53.8% streptococcus pneumoniae, 26.9% Klebsiella pneumonia as predominant organism. Mycoplasma pneumoniae and Chlamydia pneumoniae were found in 7.4% and 3.7% respectively by serological test. For Streptococcus pneumoniae, sensitive antibiotics were Amoxyclav and Levofloxacin. For Gram negative bacilli and coccobacilli, more sensitive antibiotics were Meropenem, Ceftriaxone, and Clarithromycin. The best sensitive drug were found meropenem. The mean (±SD) duration of hospital stay was 5.0±1.7 days with ranging from 3 to 10 days.Conclusion: Region based bacteroiological diagnosis of Cap is important for selecting the best and sensitive drugs for complete cure.J Bangladesh Coll Phys Surg 2016; 34(3): 128-134

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Section: Discussionmentioning

confidence: 99%

Clinical Presentation and Bacterial Etiology of Adult Community Acquired Pneumonia

Salam¹,

Amin

Islam³

2017

J. Bangladesh Coll. Phys.

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Manganese complex [Mn(CO)3(tpa-κ3N)]Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae

Liakopoulos

Ragione

Nagel

et al. 2020

Journal of Global Antimicrobial Resistance

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Manganese complex [Mn(CO)₃(tpa-κ³N)]Br increases antibiotic sensitivity in multidrug resistantStreptococcus pneumoniae

Liakopoulos

Ragione

Nagel

et al. 2020

Preprint

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AbstractThe emergence of multidrug-resistance (MDR) in Streptococcus pneumoniae clones and non-vaccine serotypes is of increasing concern, necessitating the development of novel treatment strategies. Here, we determined the efficacy of the Mn complex [Mn(CO)3(tpa-κ3N)]Br against MDR S. pneumoniae strains. Our data showed that [Mn(CO)3(tpa-κ3N)]Br has in vitro and in vivo antibacterial activity and has the potential to be used in combination with currently available antibiotics to increase their effectiveness against MDR S. pneumoniae.

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Emergence of a Unique Multiply-Antibiotic-Resistant Streptococcus pneumoniae Serotype 7B Clone in Dhaka, Bangladesh

Cited by 6 publications

References 17 publications

Clinical Presentation and Bacterial Etiology of Adult Community Acquired Pneumonia

Clinical Presentation and Bacterial Etiology of Adult Community Acquired Pneumonia

Manganese complex [Mn(CO)3(tpa-κ3N)]Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae

Manganese complex [Mn(CO)₃(tpa-κ³N)]Br increases antibiotic sensitivity in multidrug resistantStreptococcus pneumoniae

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Emergence of a Unique Multiply-Antibiotic-Resistant Streptococcus pneumoniae Serotype 7B Clone in Dhaka, Bangladesh

Cited by 6 publications

References 17 publications

Clinical Presentation and Bacterial Etiology of Adult Community Acquired Pneumonia

Clinical Presentation and Bacterial Etiology of Adult Community Acquired Pneumonia

Manganese complex [Mn(CO)3(tpa-κ3N)]Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae

Manganese complex [Mn(CO)3(tpa-κ3N)]Br increases antibiotic sensitivity in multidrug resistantStreptococcus pneumoniae

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Product

Resources

About

Manganese complex [Mn(CO)₃(tpa-κ³N)]Br increases antibiotic sensitivity in multidrug resistantStreptococcus pneumoniae