Emerging cancer incidence trends in Canada: The growing burden of young adult cancers

Abstract

BACKGROUND: Recent studies have identified increases in cancer incidence among younger adults for some cancers. This study examined incidence trends for 28 cancers in Canada by age and birth cohort from 1983 to 2012. METHODS: Canadian incidence data for 20 to 84 year-olds were obtained from the Cancer Incidence in Five Continents Plus database. Age-period-cohort modeling was used to estimate the average annual percentage changes (AAPCs) and incidence rate ratios (IRRs) for 10-year birth cohorts (reference cohort, 1943) for 28 cancer types. RESULTS: Incidence increased for 13 cancer sites among adults younger than 50 years (1983-2012), with the largest increase occurring for rectal cancer (

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

“…Recent notable findings are the increase in the incidence of stomach cancer (cardia and noncardia gastric cancers combined) among young adults (aged <50 years) in both low‐risk and high‐risk countries, including the United States, Canada, the United Kingdom, Chile, and Belarus 139,140 . A previous US study focusing on noncardia gastric cancer reported that increases among young individuals was largely confined to non‐Hispanic Whites and people living in more affluent counties 141,142 .…”

“…138 Recent notable findings are the increase in the incidence of stomach cancer (cardia and noncardia gastric cancers combined) among young adults (aged <50 years) in both low-risk and high-risk countries, including the United States, Canada, the United Kingdom, Chile, and Belarus. 139,140 A previous US study focusing on noncardia gastric cancer reported that increases among young individuals was largely confined to non-Hispanic Whites and people living in more affluent counties. 141,142 It has been postulated that the rising prevalence of autoimmune gastritis and dysbiosis of the gastric microbiome, possibly relevant to increased use of antibiotics and acid suppressants, may have contributed to the paradoxical increase of stomach cancer among younger generations.…”

Estudiantes enfermos y supervivientes de cáncer: Nuevo reto para la universidad

“…Otro de los cánceres que está incrementándose de forma rápida entre la población AJA es el cáncer de tiroides. Hay autores que explican esta alarmante subida por el sobre diagnóstico y sobre tratamiento de lesiones que si se las dejase sin actuar no causarían problemas (Heer, et al, 2020;Topstad & Dickinson, 2017). También es estadísticamente significativo el aumento entre los jóvenes del cáncer de testículo en todos los países analizados, excepto en el continente africano (Gupta et al, 2020).…”

Helicobacter pylori-Induced Inflammation: Possible Factors Modulating the Risk of Gastric Cancer

“…Moreover, owing to some paradoxical observations, it is now speculated that in addition to H. pylori infection, diet and host genetic factors are responsible for the progress from H. pylori -induced inflammation to GC [ 9 , 11 , 12 ]. A few recent studies also proposed that the increasing prevalence of autoimmune gastritis and dysbiosis of gut microbiota and increased use of antibiotics and acid suppressants, might have led to the variation in the risk of GC, primary gastric lymphoma (PGL), and neuroendocrine carcinoma [ 13 , 14 , 15 ]. Inter-individual variations on disease susceptibility of GC can also be influenced by other infections such as Epstein-Barr virus, intestinal helminths, and host genetic differences in cytokine genes [ 9 , 16 , 17 ].…”