Emerging Rodent-Borne Viral Zoonoses in Trento, Italy

Tagliapietra, Valentina; Rosà, Roberto; Rossi, Chiara; Rosso, Fausta; Hauffe, Heidi C.; Tommasini, Michele; Versini, Walter; Cristallo, Attilio Fabio; Rizzoli, Annapaola

doi:10.1007/s10393-018-1335-4

Cited by 13 publications

(20 citation statements)

References 54 publications

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“…There are very few recently published serological surveys of LCMV infection. In this study, the overall seroprevalence rate was 6.8% which is similar to the seropositivity in an Iraqi study conducted in 2012–2013 (6.4%) [ 20 ] and an Italian study conducted in 2015 (7%) [ 29 ]. In the 1990s, several studies were conducted in the Americas.…”

Section: Discussionsupporting

confidence: 83%

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

et al. 2021

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Lymphocytic choriomeningitis virus (LCMV) is a neglected human pathogen associated with aseptic meningitis, severe systemic infections in immunocompromised persons, and congenital anomalies. Data on the prevalence of LCMV infections are scarce. We analyzed the seroprevalence of LCMV in continental Croatian regions. A total of 338 serum samples of professionally exposed (forestry workers, hunters, agriculture workers in contact with rodents) and non-exposed populations (general population, pregnant women) were tested for the presence of LCMV antibodies using indirect immunofluorescence assay. No participants reported recent febrile disease. LCMV IgG antibodies were detected in 23/6.8% of participants: 9.8% exposed persons and 5.1% non-exposed persons (6.1% in the general population and 3.9% in pregnant women). No participants were LCMV IgM positive. Although higher seropositivity was found in males compared to females (8.9% vs. 4.7%), inhabitants of suburban/rural areas compared to inhabitants of urban areas (9.2% vs. 4.6%), and persons who used well as a source of water compared to those who used tap (11.4% vs. 5.6%), these differences did not reach statistical significance. Results of logistic regression showed that the presence of rodents in the house/yard and cleaning rodent nests were associated with an elevated risk for LCMV infection (OR = 2.962, 95% CI = 1.019–8.607).

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Section: Discussionsupporting

confidence: 83%

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

et al. 2021

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“…Local abiotic factors (e.g., temperature, moisture, protection from UV light) may also affect the epidemiological characteristics of PUUV and the number of NE cases, and of PUUV transmission in particular, by influencing bank vole abundance and viral persistence outside the host [ 11 , 63 , 64 , 65 ]. Ecological niche modeling has been used to predict the distribution of NE cases in Europe [ 66 , 67 ].…”

Section: Discussionmentioning

confidence: 99%

Detection and Genetic Characterization of Puumala Orthohantavirus S-Segment in Areas of France Non-Endemic for Nephropathia Epidemica

et al. 2020

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Puumala virus (PUUV) in Europe causes nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS). The incidence of NE is highly heterogeneous spatially, whereas the geographic distribution of the wild reservoir of PUUV, the bank vole, is essentially homogeneous. Our understanding of the processes driving this heterogeneity remains incomplete due to gaps in knowledge. Little is known about the current distribution and genetic variation of PUUV in the areas outside the well-identified zones of NE endemicity. We trapped bank voles in four forests in French regions in which NE is considered non-endemic, but sporadic NE cases have been reported recently. We tested bank voles for anti-PUUV IgG and characterized the S segment sequences of PUUV from seropositive animals. Phylogenetic analyses revealed specific amino-acid signatures and genetic differences between PUUV circulating in non-endemic and nearby NE-endemic areas. We also showed, in temporal surveys, that the amino-acid sequences of PUUV had undergone fewer recent changes in areas non-endemic for NE than in endemic areas. The evolutionary history of the current French PUUV clusters was investigated by phylogeographic approaches, and the results were considered in the context of the history of French forests. Our findings highlight the need to monitor the circulation and genetics of PUUV in a larger array of bank vole populations, to improve our understanding of the risk of NE.

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“…Increased epidemiological vigilance may provide some answers. In any event, it would appear to be warranted: it has been recently reported that the seroprevalence of antibodies against LCMV in the Province of Trento (Italy) has been increasing over time [34].…”

Section: Discussionmentioning

confidence: 99%

Screening of Forestry Workers in Guadalajara Province (Spain) for Antibodies to Lymphocytic Choriomeningitis Virus, Hantavirus, Rickettsia spp. and Borrelia burgdorferi

Lledó

Giménez-Pardo

Gegúndez

2019

IJERPH

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Exposure to Lymphocytic choriomeningitis virus (LCMV), hantaviruses, Rickettsia spp. and Borrelia burgdorferi among forestry workers from a province in central Spain (Guadalajara) was examined by serological screening. This is the first such study in this rural area, where people often live and work in proximity to domestic and wild animals. Immunofluorescent analyses of the serum of 100 forestry workers detected IgG antibodies to LCMV in 2% (CL 95% 0.55%–7.0%) of this population, to hantaviruses in 4% (CL 95% 1.6%–8.3%) for the serum amyloid A (SAA) serotype, and 2% (CL 95% 0.55%–7.0%) for the Seoul virus (SEO) serotype (samples also positive for SAA), to Rickettsia in 8% (CL 95% 4.1%–15%) (3% (CL 95% 1.0%–8.5%) for R. typhi and 5% (CL 95% 2.2%–11.2%) for R. slovaca, and to B. burgdorferi in 7% (CL 95% 3.4%–13.8%). The number of people who have been exposed to these organisms is commonly underestimated since most infections are asymptomatic. Greater epidemiological surveillance may therefore be recommended.

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Emerging Rodent-Borne Viral Zoonoses in Trento, Italy

Cited by 13 publications

References 54 publications

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

Prevalence and Risk Factors for Lymphocytic Choriomeningitis Virus Infection in Continental Croatian Regions

Detection and Genetic Characterization of Puumala Orthohantavirus S-Segment in Areas of France Non-Endemic for Nephropathia Epidemica

Screening of Forestry Workers in Guadalajara Province (Spain) for Antibodies to Lymphocytic Choriomeningitis Virus, Hantavirus, Rickettsia spp. and Borrelia burgdorferi

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