Emerging role of non-coding RNAs in response of cancer cells to radiotherapy

Ebahimzadeh, Kaveh; Shoorei, Hamed; Mousavinejad, Seyed Ali; Anamag, Farhad Tondro; Dinger, Marcel E.; Taheri, Mohammad; Ghafouri‐Fard, Soudeh

doi:10.1016/j.prp.2020.153327

Cited by 18 publications

(13 citation statements)

References 202 publications

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“…Selection criteria. Papers were defined as eligible studies if they met the following criteria: (1) studies of human clinical trials; (2) lncRNA involvement in radioresistance or radiosensitivity data in cancers; (3) quantitative measurement of lncRNA expression in tumor tissues; (4) the association between lncRNA expression and survival was estimated; and (5) sufficient data for the assessment of hazard ratios (HRs) and 95% confidence intervals (CIs).…”

Section: Methodsmentioning

confidence: 99%

“…However, radiotherapy resistance limits its efficacy and has become a major clinical challenge. Although the mechanisms of radioresistance in cancer cells are not clear, they likely involve a series of biological and genetic alterations, such as aberrant DNA damage response (DDR) and enhanced DNA damage repair, disorder of cell proliferation and apoptosis, and related abnormal activation molecular mechanisms 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

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LncRNAs as biomarkers for predicting radioresistance and survival in cancer: a meta-analysis

Xie

Han

Xie

2022

Sci Rep

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The effect of long noncoding RNAs (lncRNAs) on the radiotherapy response has been gradually revealed. This systematic review and meta-analysis aimed to evaluate the association between the function and underlying mechanism of lncRNAs in regulating the radiosensitivity and radioresistance of different tumors. Hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were calculated to estimate the effect of lncRNAs on cancer patient prognosis, including overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS) and progression-free survival (PFS). Collectively, 23 lncRNAs in 11 cancer types were enrolled. Of them, 13 lncRNAs were downregulated and related to radiosensitivity, 11 lncRNAs were upregulated and related to radioresistance, and 3 lncRNAs were upregulated and related to radiosensitivity in cancers. Furthermore, 17 microRNAs and 20 pathways were targeted by different lncRNAs and contributed to the cancer radiotherapy response in this meta-analysis. The individual pooled HRs (95% CIs) of downregulated radiation-resistant and upregulated radiation-resistant lncRNAs for OS were 0.49 (0.40–0.60) and 1.88 (1.26–2.79), respectively. Our results showed that lncRNAs could modulate tumor radioresistance or sensitivity by affecting radiation-related signaling pathways and serve as potential biomarkers to predict radiotherapy response.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

LncRNAs as biomarkers for predicting radioresistance and survival in cancer: a meta-analysis

Xie

Han

Xie

2022

Sci Rep

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“…However, there are still some unavoidable problems in radiotherapy, for example, how to reduce side effects and implement precision radiotherapy strategies. Of these problems, radiation tolerance is a common and intertwined phenomenon that impedes therapeutic efficacy, resulting in the neoplasm recrudescence or poor prognosis after radiotherapy ( 3 , 4 ). Consequently, it is of great significance to uncover the mechanisms of radiation resistance, predict sensitivity to radiotherapy in patients and formulate strategies to overcome radioresistance.…”

Section: Introductionmentioning

confidence: 99%

CircRNAs in Malignant Tumor Radiation: The New Frontier as Radiotherapy Biomarkers

Wang

et al. 2022

Front. Oncol.

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World Health Organization (WHO) data show that of the top 20 factors that threaten human life and health, cancer is at the forefront, and the therapeutic approaches for cancer consist of surgery, radiotherapy, chemotherapy and immunotherapy. For most highly metastatic and recurrent cancer, radiation therapy is an essential modality to mitigate tumor burden and improve patient survival. Despite the great accomplishments that have been made in clinical therapy, an inevitable challenge in effective treatment is radioresistance, the mechanisms of which have not yet been completely elucidated. In addition, radiosensitization methods based on molecular mechanisms and targets, and clinical applications are still inadequate. Evidence indicates that circular RNAs (circRNAs) are important components in altering tumor progression, and in influencing resistance and susceptibility to radiotherapy. This review summarizes the reasons for tumor radiotherapy resistance induced by circRNAs, and clarifies the molecular mechanisms and targets of action. Moreover, we determine the potential value of circRNAs as clinical indicators in radiotherapy, providing a theoretical basis for circRNAs-based strategies for cancer radiotherapy.

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“…The involvement of ncRNAs in the regulation of tumour proliferation, migration and invasion has been demonstrated in many studies [11][12][13] and is related to chemotherapy resistance and radiation resistance. 14,15 In this review, the involvement of miRNAs and lncRNAs in chemotherapy and radiotherapy for nasopharyngeal carcinoma will be described, and a preliminary investigation of the molecular mechanisms that may be involved is conducted.…”

Section: Introductionmentioning

confidence: 99%

“…The involvement of ncRNAs in the regulation of tumour proliferation, migration and invasion has been demonstrated in many studies 11–13 and is related to chemotherapy resistance and radiation resistance. 14 , 15 …”

Section: Introductionmentioning

confidence: 99%

Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma

Xiao

2021

CMAR

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Emerging role of non-coding RNAs in response of cancer cells to radiotherapy

Cited by 18 publications

References 202 publications

LncRNAs as biomarkers for predicting radioresistance and survival in cancer: a meta-analysis

LncRNAs as biomarkers for predicting radioresistance and survival in cancer: a meta-analysis

CircRNAs in Malignant Tumor Radiation: The New Frontier as Radiotherapy Biomarkers

Involvement of Non-Coding RNAs in Chemo- and Radioresistance of Nasopharyngeal Carcinoma

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