Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine

Hemshekhar, Mahadevappa; Thushara, R. M.; Siddaiah, Chandranayaka; Sherman, Larry S.; Kemparaju, K.; Girish, K. S.

doi:10.1016/j.ijbiomac.2016.02.032

Cited by 232 publications

(114 citation statements)

References 114 publications

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“…A graphic representation of the synthesis process is shown in Figure . Hyaluronic acid is a linear polysaccharide found to have significant involvement in maintaining extracellular skin moisture and viscoelasticity . A 42.8% luteolin incorporation efficiency was achieved, and the highest drug release was observed at 25 °C and pH 5.5 while conditions similar to that of psoriasis skin conditions, 37 °C and pH 7.4, a gradual drug release was observed.…”

Section: Natural Smart Polymersmentioning

confidence: 99%

Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond

Frazar

Shah

Dziubla

et al. 2019

J of Applied Polymer Sci

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The versatility and applicability of thermoresponsive polymeric systems have led to great interest and a multitude of publications. Of particular significance, multifunctional poly(N‐isopropylacrylamide) (PNIPAAm) systems based on PNIPAAm copolymerized with various functional comonomers or based on PNIPAAm combined with nanomaterials exhibiting unique properties. These multifunctional PNIPAAm systems have revolutionized several biomedical fields such as controlled drug delivery, tissue engineering, self‐healing materials, and beyond (e.g., environmental treatment applications). Here, we review these multifunctional PNIPAAm‐based systems with various cofunctionalities, as well as highlight their unique applications. For instance, addition of hydrophilic or hydrophobic comonomers can allow for polymer lower critical solution temperature modification, which is especially helpful for physiological applications. Natural comonomers with desirable functionalities have also drawn significant attention as pressure surmounts to develop greener, more sustainable materials. Typically, these systems also tend to be more biocompatible and biodegradable and can be advantageous for use in biopharmaceutical and environmental applications. PNIPAAm‐based polymeric nanocomposites are reviewed as well, where incorporation of inorganic or carbon nanomaterials creates synergistic systems that tend to be more robust and widely applicable than the individual components. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48770.

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Section: Natural Smart Polymersmentioning

confidence: 99%

Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond

Frazar

Shah

Dziubla

et al. 2019

J of Applied Polymer Sci

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“…40 It is a glycosaminoglycan comprised of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid. HA is synthesized by hyaluronan synthases and reaches sizes in excess of 2MDa.…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

“…It plays numerous roles in normal tissues but also has been implicated in inflammatory processes, multiple drug resistance, angiogenesis, tumorigenesis, water homeostasis, and altered viscoelasticity of extracellular matrix. 40 Cross-linked hyaluronic acid hydrogel (cHA gel) and dexamethasone (Dex) are used to treat knee osteoarthritis (OA). It shows chondroprotective and anti-inflammatory effects.…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

“…These cytocompatible gels can serve to modulate the cellular phenotype of human mammary cancer epithelial cells as well as mouse myoblasts. 40 Thiolated hyaluronic acid derivative (HA-SH) are prepared and applied as a three-dimensional scaffold to mimic native extracellular matrix (ECM) for the culture of fibroblasts cells (L929) and chondrocytes. 41 HA-SH hydrogels show intelligent degradation behavior, excellent biocompatibility and convenient operational characteristics.…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

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Use of Polysaccharide Hydrogels in Drug Delivery and Tissue Engineering

Upadhyay¹

2017

ATROA

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Present review article aims to explain use of injectable hydrogels and microspheres derived from natural polysaccharides as drug delivery systems and cell scaffolds. Polysaccharides isolated from natural sources are proved much better than synthetic polymers for making single and composite hydrogels. This paper emphasizes recent developments occurred in use of amphiphilic polysaccharides for biomedical applications. It also explains use of various injectable polysaccharide structure-based hydrogels such as carboxymethyl chitin, hyaluronic acid, PTX-loaded modified hydrogels, Thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogel, Gellan Gum ,Chitin-CaSO4-nano-fibrin based injectable gel system, nanocomposite hydrogels, chondroitin Sulfate, photo-crosslinked gelatin methacrylate (GelMA) and thermosensitive chitosan/dextran-polylactide/glycerophosphate hydrogels and its functions in engineering cartilage tissue and injectable chemistries. More specifically, this paper high light use of combining analogous matrices with cells/stem cells and biomolecules and multi component approaches for making mimetic constructs. There is a need to develop more advanced designs of polysaccharide-based injectable hydrogels to widen the horizons of clinical drug delivery applications in biomedical engineering and several fields related to pharmaceutics.

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“…In recent years, the use of biomaterials building with a structure similar to sponges has generated a growing interest in pharmaceutical and medical fields particularly for drug controlled delivery and scaffold building for the enhancement of cell growth and tissue regeneration …”

Section: Introductionmentioning

confidence: 99%

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

Orellana

Giacaman

Pavicic

et al. 2016

J Biomedical Materials Res

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The study of biomaterials by electrical charge scaling to explore the role of net charge on biocompatibility and suitability for tissue regeneration has been limited as has the search for products that could improve this first-rate variable. In the present study, we prepared sponges composed of chitosan/alginate (CS/ALG) with or without hyaluronic acid (HA) by mixing polymer stock solutions of different net electric charge ratios (n(+/) n(-) ), and then lyophilizing them to obtain porous materials. The electric charge ratios n(+/) n(-) studied were 0.3, 0.8, 1.0, and 2.5 for CS/ALG and 0.3, 1.0, 1.9, and 3.7 for CS/ALG/HA sponges. Under these conditions a role for net electric charge balance over sponge microstructure rearrangement, protection to dissolution, cellular proliferation, and cell-cell interactions was apparent, effects that were enhanced by copolymer modification with HA. Mass balance, electric charge, and specific products that influence both such as HA, have a potential in biomaterials for wound healing. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2537-2543, 2016.

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Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine

Cited by 232 publications

References 114 publications

Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond

Multifunctional temperature‐responsive polymers as advanced biomaterials and beyond

Use of Polysaccharide Hydrogels in Drug Delivery and Tissue Engineering

Relevance of charge balance and hyaluronic acid on alginate‐chitosan sponge microstructure and its influence on fibroblast growth

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