Emerging use of nanoparticles in diagnosis and treatment of breast cancer

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

“…In the method developed by Quintanar-Guerrero et al (D'Mello et al, 2006;Yezhelyev et al, 2006), the solvent and water are mutually saturated at room temperature before use to ensure the initial thermodynamic equilibrium of both liquids. Later, the organic solvent containing the dissolved polymer and the drug is emulsified in an aqueous surfactant solution (typically with PVA as a stabilizing agent) by using a high-speed homogenizer.…”

Impact of nanotechnology in breast cancer

“…Nanotechnology refers to the scientific field that deals with the creation, manipulation and utilization of engineered manmade functional particles in nanoscale dimension (1-1000 nm range in at least one dimension), and applies them at atomic or molecular levels [1][2][3][4].…”

“…Hence, nanomaterials allow unique interaction with biological systems at the molecular level, which has led to the development of 'nano-oncology' applications in tumor biomarker detection and profiling, diagnostic imaging of tumors in vivo and delivering better targeted therapies [1][2][3][4].…”

“…Editorial Haq, Zabkiewicz, Grange & Arya the benefit of endocrine treatments, and the presence of HER2 (ERBB2) protein overexpression or gene amplification determines benefit from the monoclonal antibody, trastuzumab [1,2]. Immunohistochemistry used for their detection on tumor specimens is limited by difficulty in quantitative analysis due to background 'noise', signal degradation and inability to detect different proteins simultaneously on the same specimen.…”

“…Quantum dots are semiconductor strongly fluorescent nanoparticles that can be tuned to fluoresce under a light source of specific wavelength, between 450 and 850 nm (from UV to near infrared) [2][3][4]. The unique fluorescent emission peaks of different quantum dots can be easily detected and quantified with spectrometry [2][3][4][5].…”