Emollient foam in topical drug delivery

Tamarkin, Dov; Friedman, Doron; Shemer, Avner

doi:10.1517/17425247.3.6.799

Cited by 36 publications

(23 citation statements)

References 4 publications

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“…Then the foam was replaced by identical volume of deionized water. Foam density was calculated according to the Equation (1) (Tamarkin et al, 2006):…”

Section: Characterization Of Foammentioning

confidence: 99%

Expansible thermal gelling foam aerosol for vaginal drug delivery

Mei

Chen

et al. 2017

Drug Delivery

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Vaginal delivery of antimicrobial drugs is the most effective method for the local treatment of the vaginal infections. However, current vaginal drug delivery systems (VDDS), including gel, lotion, aerosol and cream, are suffering from low penetration in the deep vaginal rugae and easy elimination by self-cleaning of vaginal canal. To address these issues, a foam aerosol based on the thermal transformation was designed to improve penetration efficiency and achieve the extended retention. The expansible thermal gelling foam aerosol (ETGFA) consisting of thermal sensitive matrix, silver nanoparticle, adhesive agent and propellant, was optimized by evaluations of precursor viscosity, foam expansion, thermal gelation, gel adhesiveness, antimicrobial effects and tissue irritation. The ETGFA would penetrate to the deep vaginal rugae to cover the infectious sites by foam expansion. Drug leakage was intended to be avoided by the thermal gelation at physiological temperature before foam collapse. The gel could be retained in the vaginal canal for extended time due to its superior adhesiveness when compared to the commercial gel Asimi V R . The ETGFA provided extended drug release for over 4 h and maintained effective drug concentrations at the infectious sites. The ETGFA containing silver nanoparticles showed dose-dependent antimicrobial effects on the vaginal floras and irritation reduction to the vaginal tissues. The results demonstrated that the ETGFA could overcome the limitations of conventional dosage forms, including poor drug penetration, carrier retention and patient compliance and satisfied the requirements for vaginal drug delivery. ARTICLE HISTORY

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“…Then the foam was replaced by identical volume of deionized water. Foam density was calculated according to the Equation (1) (Tamarkin et al, 2006):…”

Section: Characterization Of Foammentioning

confidence: 99%

Expansible thermal gelling foam aerosol for vaginal drug delivery

Mei

Chen

et al. 2017

Drug Delivery

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“…They offer more convenient topical drug delivery with easy application and spreadability characteristics in comparision to other topical dosage forms [84,85].…”

Section: Formulations Of Tcmentioning

confidence: 99%

Corticosteroids for Skin Delivery: Challenges and New Formulation Opportunities

Şenyiğit¹,

Özer²

2012

Glucocorticoids - New Recognition of Our Familiar Friend

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“…They offer more convenient topical drug delivery with easy application and spreadability characteristics in comparision to other topical dosage forms [156,157].…”

Section: Foamsmentioning

confidence: 99%

Innovative Topical Formulations for Treatment of Dermatitis

Şenyiğit

Özcan²,

Özer³

2012

IAD

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The treatment of dermatitis with conventional dosage forms (ointment, cream, lotion etc.) has many concerns due to side effects especially in long-term therapy. Recent studies focused on strategies to optimize the potency of formulation while minimizing side effects. Several attempts have been made to increase the safety of treatment, including special vehicles (nanoparticle, liposome, patch etc.), combined therapy and new synthesized agents. This review provides major innovations and advances of new approaches for dermatitis treatment based on the published articles and patent applications.

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Emollient foam in topical drug delivery

Cited by 36 publications

References 4 publications

Expansible thermal gelling foam aerosol for vaginal drug delivery

Expansible thermal gelling foam aerosol for vaginal drug delivery

Corticosteroids for Skin Delivery: Challenges and New Formulation Opportunities

Innovative Topical Formulations for Treatment of Dermatitis

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