Background: Organizations that need to continue, develop, sustain their competitive advantage and become more effective will exert effort to attract, hire, develop, improve, as well as retain nurses, particularly those with extraordinary talents and more emotionally intelligent able to manage one's own emotions and to handle others. Aim of the study: Investigate relation of head nurses' talent management and their emotional intelligence with organizational effectiveness at Medical Specialty Hospital Subject and Method: Design: Descriptive correlational design was used. Subject: The study was conducted at Specialty Medical Hospital and the study included all available head nurses (n=95) at the time of data collection. Tools: There are three tools were used which are talent management questionnaire, emotional intelligence self -assessment tool and organizational effectiveness questionnaire. Results: The study results showed that more than half of head nurses showed high level of talent management, emotional intelligence, and level of organizational effectiveness as perceived by head nurses. Talent development was the highest dimension of talent management while talent attraction was the lowest. Regarding emotional intelligence dimensions, the highest mean score was related to self-awareness while, the lowest was social awareness. Finally, according to the mean score of organizational effectiveness dimensions, the highest was related to job satisfaction while, the lowest mean score related to personal relationship. Conclusion: There was statistically significant positive relation between organizational effectiveness and both head nurses talent management and emotional intelligence. Recommendations: To maintain high organizational effectiveness, it is necessary for organization to give more attention and consideration to manage who talents. Equip supervisors and managers with talent attraction innovative strategies to be better at attracting, motivating, and maintaining best talents. Encourage head nurses to enhance social awareness and for continuous personal growth and development.