Empirical Treatment of Low-level Leukocytospermia With Doxycycline in Male Infertility Patients

Dermatological medication effects on male fertility

“…Greater pregnancy rate and improvement in leukocytospermia found with doxycycline use in one study .…”

“…In vitro study showed tetracycline and erythromycin impaired sperm movement and sperm viability (recovery after 20 hours of incubation without medications) (81). Greater pregnancy rate and improvement in leukocytospermia found with doxycycline use in one study (80). Studies showed no effect of erythromycin and doxycycline on males with low sperm (82,83).…”

Unexplained Male infertility: diagnosis and Management

“…These leukocytes can be activated by infection and inflammation, in which case they are capable of producing 100 times greater amounts of ROS than inactivated leukocytes (45,46). In addition, even low level leukocytospermia (below 1 million of white blood cells per 1 milliliter of semen) has been recently discovered to be harmful, and therapy of such low levels of leukocytes may result in improvement in pregnancy rates (43,47).…”

“…However, large clinical trials are still necessary to identify the superiority of one antioxidant over the other in different subpopulations of infertile males, as well as other important aspects such as dose and duration of therapy. Lastly, Hamada et al reported that even low level leukocytospermia (important source of ROS) may be harmful and prescribing doxycycline 200 mg twice daily for three weeks results in significant improvement in pregnancy rates (47).…”

Relation between oxidative stress and sperm DNA damage

“…В том числе по этой причине инфекционный и воспали-тельный процессы должны быть устранены у паци-ентов с бесплодием. Замечено, что назначение анти-бактериальной терапии даже при незначительной лейкоцитоспермии (0,2 -1·10 6 в 1 мл) приводило к существенному увеличению числа пар, в которых на-ступала спонтанная беременность, именно по этой причине, видимо, следует пересмотреть ту концен-трацию лейкоцитов в сперме, с которой необходимо начинать лечебные мероприятия [43].…”