Empyema caused by infection with Clostridium septicum in a patient with lung cancer

Kreling, Gabriel Afonso Dutra; Dagostin, Marília A.; Park, Marcelo

doi:10.1590/s1806-37562017000000466

Cited by 6 publications

(3 citation statements)

References 10 publications

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“… 3 In fact, only 4 cases have been reported in the English literature over the past 10 years. Among these studies, proposed etiologies included underlying lung malignancy, 4 , 5 cirrhosis complicated by hepatic hydrothorax, 6 and aspiration of oropharyngeal contents. 1 Other etiologies of pleuropulmonary infection from Clostridia bacteria previously reported included trauma or iatrogenic contamination of chest wall and pleural cavity, 1 , 7 chronic disease or immune system impairment, 6 , 8 pulmonary embolization and lung infarction, 9 and bacteremia from a secondary focus of infection.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 7 The most commonly identified species of Clostridium is Clostridium perfringens , however infection with C. sordellii , C. sporogenes , C. paraputrificum , and C. bifermentans have also been reported.4 Disease pathogenesis is attributed to release of potent extracellular toxins that provoke vascular leukocytosis and limit polymorphonuclear leukocyte response to invading microorganisms, leading to tissue necrosis with abscess formation or empyema. 4 , 10 Given that Clostridia bacterial infection is an infrequently observed pathogen in pulmonary disease and early symptomatology may mimic features of an acute pneumococcal pneumonia, delays in diagnosis and management are common. 11 Herein, we report a rare case of pulmonary empyema secondary to probable hematogenous seeding or transdiaphragmatic extension of C. perfringens from complicated cholecystitis.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Clostridium perfringens: Seeding beyond the gastrointestinal tract

Delungahawatta,

Rao,

Wolff

et al. 2024

Journal of Community Hospital Internal Medicine Perspectives

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Clostridia perfringens infection outside the gastrointestinal system is rare. Here, we report on a 75-year-old man with history of end-stage renal disease presenting after a syncopal event with lactic acidosis, leukocytosis, and mild hyper-bilirubinemia. Chest imaging revealed a loculated, left-sided pleural effusion; diagnostic thoracentesis identified Clostridia perfringens , consistent with an empyema. Video-assisted thoracic left lung decortication was performed; tissue culture also speciated Clostridia perfringens . Further imaging revealed concomitant acute cholecystitis, suggesting hematogenous seeding or transdiaphragmatic extension of Clostridia perfringens to pleural space from an abdominal source. The patient was successfully managed with laparoscopic cholecystectomy and discharged on a one-month course of amoxicillin-sulbactam. This case highlights the potential for Clostridia perfringens to produce a pleuropulmonary infection, necessitating timely diagnosis and intervention, to improve patient outcomes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pulmonary Clostridium perfringens: Seeding beyond the gastrointestinal tract

Delungahawatta,

Rao,

Wolff

et al. 2024

Journal of Community Hospital Internal Medicine Perspectives

View full text Add to dashboard Cite

show abstract

“…(4,5) La tercera fase, la de mayor complejidad -conocida como fase organizada u organizativa-evidencia formación de membranas de fibrinas amarillo-verdosas, laparoscópicos que resultan indispensables para confirmar la presencia de esta enfermedad. (11,12)…”

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Empiema pleural. Opciones terapéuticas

Hachi Powel,

Guaman Muñoz,

Chichande Vera

et al. 2023

Afecciones Clínico-Quirúrgicas Frecuentes en La Infancia

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El empiema pleural es es una entidad clínica frecuente en la edad pediátrica y consiste en el acúmulo de fluido purulento en la cavidad pleural como respuesta a un proceso infeccioso. Se presenta aproximadamente en un 10% de los pacientes con infecciones respiratorias. Es más común en niños menores de 5 años, inmunodeprimidos, con parálisis cerebral infantil, cardiopatías congénitas, enfermedades pulmonares crónicas como la fibrosis quística, así como en pacientes con neumonías bacterianas, virales o micóticas.El cuadro clínico se caracteriza por malestar, fatiga, anorexia, dificultad respiratoria que se manifiesta con polipnea, tirajes intercostales y subclaviculares, tos, dolor torácico y fiebre.Entre las opciones terapéuticas actuales para esta enfermedad está el tratamiento médico de sostén, que incluye ingreso hospitalario, hidratación, oxígeno suplementario de acuerdo con la necesidad, medidas de apoyo vital y antibióticos de amplio espectro. La cirugía como tratamiento resolutivo tiene sus indicaciones, la cual debe ser aplicada oportunamente para evitar complicaciones.El pronóstico de esta afección es todavía reservado y la evolución será mejor si el diagnóstico y tratamiento se realiza precozmente. Aun así, hoy en día el pronóstico es más favorable gracias a la creación, ampliación y equipamiento de las unidades de

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Overexpression of the Long Noncoding RNA HIF2PUT Inhibits Non-Small Cell Lung Cancer Cell Proliferation and Invasion Through HIF-2a Pathway

Wang¹,

Tian

et al. 2023

Cancer Biotherapy and Radiopharmaceuticals

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Empyema caused by infection with Clostridium septicum in a patient with lung cancer

Cited by 6 publications

References 10 publications

Pulmonary Clostridium perfringens: Seeding beyond the gastrointestinal tract

Pulmonary Clostridium perfringens: Seeding beyond the gastrointestinal tract

Empiema pleural. Opciones terapéuticas

Overexpression of the Long Noncoding RNA HIF2PUT Inhibits Non-Small Cell Lung Cancer Cell Proliferation and Invasion Through HIF-2a Pathway

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