Enantioanalysis of L-Histidine Using Enantioselective, Potentiometric Membrane Electrodes Based on Maltodextrins

Staden, Raluca‐Ioana Stefan‐van; Holo, Luxolo

doi:10.1080/00032719.2010.506935

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…This sensor was successfully used to measure d -His in pharmaceutical samples. The same author reported another potentiometric His sensor using maltodextrins as the sensing element [ 402 ]. The applicability of this potentiometric sensor was compared to capillary electrophoresis, wherein both methods showed almost the same performance for His determination.…”

Section: Electrochemical Analysis Of Amino Acidsmentioning

confidence: 99%

“…Apart from the five abovementioned amino acids, other amino acids show almost no detectable voltammetric signal in aqueous solutions. Exploiting electrochemical methods like potentiometry [ 402 ] or electrochemical impedance spectroscopy (EIS) might be the solution, since these methods do not require electroactive analytes to work. On the other hand, some literature mentioned that the addition of some substances can trigger the electroactivity of amino acids, e.g., Cu (II) for the detection of histidine [ 399 ].…”

Section: Conclusion: Challenges and Opportunitiesmentioning

confidence: 99%

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Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Moulaee

Neri

2021

Biosensors

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The rapid growth of research in electrochemistry in the last decade has resulted in a significant advancement in exploiting electrochemical strategies for assessing biological substances. Among these, amino acids are of utmost interest due to their key role in human health. Indeed, an unbalanced amino acid level is the origin of several metabolic and genetic diseases, which has led to a great need for effective and reliable evaluation methods. This review is an effort to summarize and present both challenges and achievements in electrochemical amino acid sensing from the last decade (from 2010 onwards) to show where limitations and advantages stem from. In this review, we place special emphasis on five well-known electroactive amino acids, namely cysteine, tyrosine, tryptophan, methionine and histidine. The recent research and achievements in this area and significant performance metrics of the proposed electrochemical sensors, including the limit of detection, sensitivity, stability, linear dynamic range(s) and applicability in real sample analysis, are summarized and presented in separate sections. More than 400 recent scientific studies were included in this review to portray a rich set of ideas and exemplify the capabilities of the electrochemical strategies to detect these essential biomolecules at trace and even ultra-trace levels. Finally, we discuss, in the last section, the remaining issues and the opportunities to push the boundaries of our knowledge in amino acid electrochemistry even further.

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Section: Electrochemical Analysis Of Amino Acidsmentioning

confidence: 99%

Section: Conclusion: Challenges and Opportunitiesmentioning

confidence: 99%

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Moulaee

Neri

2021

Biosensors

View full text Add to dashboard Cite

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Chiral recognition of penicillamine enantiomers based on a vancomycin membrane electrode

et al. 2013

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An enantioselective membrane electrode based on vancomycin (Van) was proposed for the assay of penicillamine enantiomers. Cyclic voltammetry, electrochemical impedance spectroscopy, atomic force microscopy and UV-Vis spectra were employed to investigate the chiral recognition phenomenon. The results exhibited that the binding effect between D-penicillamine (D-Pen) and the proposed Van membrane electrode was obviously stronger than that of L-penicillamine (L-Pen). In addition, the amount of Van, the pH of the supporting electrolyte solution and the concentration of Pen enantiomers were systematically investigated and optimized. The association constant (K) was calculated to be 1.05 Â 10 4 L mol À1 for D-Pen and 1.40 Â 10 2 L mol À1 for L-Pen. The enantioselective concentration range of the proposed membrane electrode is 10 À7 to 10 À2 mol L À1 . The results suggested that the chiral selective membrane has the potential to discriminate and determine chiral drugs in the pharmaceutical application of electrochemical analysis. Fig. 1 The structures of (a) Van and (b) Pen.

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Enantioanalysis of L-Histidine Using Enantioselective, Potentiometric Membrane Electrodes Based on Maltodextrins

Cited by 2 publications

References 22 publications

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Chiral recognition of penicillamine enantiomers based on a vancomycin membrane electrode

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