Enantioselective Determination of R-Clenbuterol Using an Enantioselective, Potentiometric Membrane Electrode Based on a β-Cyclodextrin Derivative

Electrochemistry of Cyclodextrin Inclusion Complexes of Pharmaceutical Compounds

“…Binding constants in solution are usually determined from potentiometric titrations or plots of cyclic voltammetry peak potentials vs CD concentration after assessing the guest/host ratio in the complex [33,34]. Potentiometric measurements are more frequently used in studying the inclusion complexes of pharmaceutical compounds with cyclodextrins [35][36][37][38][39][40][41][42][43][44][45][46][47][48], and ion-selective electrodes are employed, for the direct measurement of the guest activity in the solution [49][50][51][52]. Decreased peak currents in cyclic voltammetry and shifts in the oxidation and reduction potentials are observed on complexation, owing to the smaller diffusion coefficients of the complexes than that of the guest alone, and to the relatively high stability of these complexes.…”