Enantioseparation of antiarrhythmic drugs propafenone and diprafenone, their metabolites and analogs by capillary electrophoresis

Chankvetadze, Bezhan; Lomsadze, Ketevan; Blaschke, Gottfried

doi:10.1002/1615-9314(20010901)24:9<795::aid-jssc795>3.0.co;2-v

Cited by 13 publications

(6 citation statements)

References 29 publications

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“…However, this technique is not always flexible and may be associated with certain technical hurdles such as backpressure, very long analysis time, etc. The combination of two cyclodextrin derivatives, carboxymethyl-b-CD and sulfated-b-CD, in CE allowed almost baseline enantioseparations of all analytes and their enantiomers (Figure 7.b) [72]. This complex separation system allowed the resolution of the enantiomers of the native drug (PF) and N-Des-PF.…”

Section: Capillary Electrophoresis Vs High Performance Liquid Chromamentioning

confidence: 99%

“…Mobile phase in HPLC was 1% MeOH, 99% TEAA buffer (pH 5.5) and BGE in CE was 100 mM triethanolamine phosphate at pH 3.0[69,70]. Mobile phase in HPLC was 1% MeOH, 99% TEAA buffer (pH 5.5) and BGE in CE was 100 mM triethanolamine phosphate at pH 3.0[69,70].…”

mentioning

confidence: 99%

“…UV detection was performed at 214 nm[71,72]. Mobile phase flow-rate 1.0 mL/min, (b) CE enantioseparation with a mixture of sulfated b-CD (SU-b-CD) and carboxymethyl-b-CD (CM-b-CD).…”

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confidence: 99%

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Enantioseparation of chiral drugs and current status of electromigration techniques in this field

Chankvetadze

2001

J. Sep. Science

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Section: Capillary Electrophoresis Vs High Performance Liquid Chromamentioning

confidence: 99%

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confidence: 99%

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Enantioseparation of chiral drugs and current status of electromigration techniques in this field

Chankvetadze

2001

J. Sep. Science

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“…LC-flourescence detection [8] and LC-UV [9] detection were adopted for determination of propafenone. LC-MS [10], HPLC-MS [11], GC-MS [12], GCelectron-capture detection [13], TLC [14] and capillary electrophoresis [15] were also used for determination of the drug and its metabolites in pharmaceutical formulations and biological fluids. Propafenone was determined in blood serum using adsorptive-stripping voltammetry [16].…”

Section: Introductionmentioning

confidence: 99%

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods

et al. 2013

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KEYWORDSSeveral simple, sensitive, accurate and inexpensive spectrophotometric and spectrofluorimetric methods were developed for the determination of propafenone HCl and diltiazem HCl using 4-chloro-7-nitrobenzofurazan (NBD-Cl) accompanied with kinetic study, either in pure form or in pharmaceutical preparations. In this work, the cited drugs react with (NBD-Cl) in presence of borate buffer of pH = 7.6 at a fixed time of 30 minutes on thermostated water bath at (75-80 °C). The absorbance was measured using spectrophotometric technique at 489 and 481 nm for propafenone HCl and diltiazem HCl, respectively, or by using spectrofluorimetric technique after dilution at the specific wavelength of excitation and emission.The calibration curves were linear in the range of 4-44, 16-96 µg/mL when using spectrophotometric method, and 0.4-3.6, 1.6-8.8 µg/mL when spectrofluorimetric method was applied for propafenone HCl and diltiazem HCl, respectively. The limit of quantitation and the limit of detection were also calculated. The methods were applied successfully to commercial dosage form and can be further applied for their determination on a large scale in quality control laboratories. The obtained results statistically agreed with those obtained by reference methods. The determination of the studied drugs by the fixed concentration and rate constant methods is feasible with the calibration equations obtained, but the fixed time method proves to be more applicable.Diltiazem HCl Propafenone HCl Spectroflourimetric Spectrophotometric Kinetic determination 4-Chloro-7-nitrobenzofurazan

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“…A spectrophotometric [16] and spectrofluorimetric methods were reported for its determination [17]. Several methods including capillary electrophoresis [18,19], HPLC methods [20][21][22][23] were reported for propafenone enantio selective determination and its metabolites in human plasma. Other reported methods of analysis include LC-MS [24].…”

Section: Introductionmentioning

confidence: 99%

Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

et al. 2012

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A simple, precise, rapid, and low-cost conductometric method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl in pure form and in pharmaceutical formulations using silver nitrate has been described. The method is based on the precipitation of oxalate or chloride ions coming from the cited drugs with silver ions, yielding silver oxalate or silver chloride and the conductance of the solution is measured as a function of the volume of titrant. The studied drugs were evaluated in double distilled water in the range of 1-15 mg. Various experimental conditions were established and results obtained showed good recoveries with relative standard deviation of 0.909, 0.955 and 0.983 for naftidrofuryl, propafenone and sotalol, respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations. Results were favorably comparable to the official or reference methods.Oxalate Sotalol HCl Silver nitrate Propafenone HCl Naftidrofuryl oxalate Conductometric titration

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Enantioseparation of antiarrhythmic drugs propafenone and diprafenone, their metabolites and analogs by capillary electrophoresis

Cited by 13 publications

References 29 publications

Enantioseparation of chiral drugs and current status of electromigration techniques in this field

Enantioseparation of chiral drugs and current status of electromigration techniques in this field

Application of 4-chloro-7-nitrobenzofurazan for the analysis of propafenone and diltiazem hydrochlorides using kinetic spectrophotometric and spectrofluorimetric methods

Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

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