Encapsulated magnetite particles for biomedical application

Abstract

The process of miniemulsification allows the generation of small, homogeneous, and stable droplets containing monomer or polymer precursors and magnetite which are then transferred by polymer reactions to the final polymer latexes, keeping their particular identity without serious exchange kinetics involved. It is shown that the miniemulsion process can excellently be used for the formulation of polymer-coated magnetic nanoparticles which can further be used for biomedical applications. The use of high shear, appropriate surfactants, and the addition of a hydrophobe in order to suppress the influence of Ostwald ripening are key factors for the formation of the small and stable droplets in miniemulsion and will be discussed. Two different approaches based on miniemulsion processes for the encapsulation of magnetite into polymer particles will be presented in detail.

Magnetic bead handling on-chip: new opportunities for analytical applications

“…The synthesis and applications of (nonmagnetic) polymer microparticles were reviewed by Kawaguchi (2000). The articles of Landfester and Ramirez (2003), Bergemann et al (1999), and Gruttner et al (2001) present specific short review sections on the synthesis and chemical modifications of magnetic beads. The synthesis of magnetic beads is also a well covered subject in the patent literature.…”

Magnetic Properties of Encapsulated Magnetite in PLGA Nanospheres

“…The constituents of magnetite polymer nanoparticles play different roles: the polymeric matrix acts as a shell, reservoir, and vehicle for the active component, whereas magnetite is the component which makes targeting possible by external magnetic field manipulation. Magnetite polymer nanoparticles can be used for delivery of active components, such as drugs, vaccines, proteins, enzymes and others [2]. The aim of our paper is to prepare poly D,L/lactide-co-glycolide acid (PLGA) nanospheres loaded with biocompatible magnetic fluids (MFs) by modified nanoprecipitation technique and investigate their magnetic properties.…”

Magnetorheological Properties of Aqueous Ferrofluids

“…For example, a coating with a biocompatible surfactant may result in a biocompatible magnetic fluid. 5) Similar to magnetorheological (MR) fluids, under a magnetic field the chain-like structures are formed from the magnetic particles and aligned in the direction of the magnetic field. 6), 7) This phenomenon was demonstrated by Hayes and Hwang using the water-based ferrofluids.…”