Encapsulation of lutein in liposomes using supercritical carbon dioxide

Zhao, Lisha; Temelli, Feral; Curtis, Jonathan M.; Chen, Lingyun

doi:10.1016/j.foodres.2017.06.055

Cited by 91 publications

(48 citation statements)

References 46 publications

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“…Results of the particle size study showed that astaxanthin-loaded liposomes had a diameter ranging from 98.32 to 114.33 nm, as shown in Table 4. As the phospholipid content increased, the size of liposomes significantly increased (p> 0.05) as was also reported by [37]. The phospholipids are an important part of the formation of liposomes; as the amount of phospholipids increases, the particle size increased.…”

Section: The Physical and Chemical Properties Of Astaxanthin-loaded Lsupporting

confidence: 82%

Effects of Shrimp Waste Types and Their Cooking on Properties of Extracted Astaxanthin and Its Characteristics in Liposomes

Darachai¹,

Limpawattana²,

Hawangjoo³

et al. 2019

JFNR

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This study was aimed to evaluate the effects of shrimp waste types (fresh head, cooked head, fresh shell and cooked shell) and of cooking these wastes on the properties of astaxanthin. The astaxanthin was subject to liposomal encapsulation and its characteristics were determined. Astaxanthin was extracted from fresh and cooked (90°C for 15 min) materials, and then yield, astaxanthin content, antioxidant activities (DPPH and ABTS scavenging assays) and fatty acid profiles were determined. Phospholipid was used at various concentrations (2, 3 and 4 % w/v) to prepare astaxanthin-loaded liposomes, which were further evaluated for particle size, zeta potential, antioxidant activity (DPPH scavenging assays) and outer structure by confocal laser scanning microscope. The results showed that fresh shrimp heads gave the highest percent yield (30.49 mg extract/g raw material), but the highest astaxanthin content was found in fresh shrimp shells (14.65 mg/g). Shrimp heads and shrimp shells, both fresh and cooked, were significantly different (p<0.05) in terms of their antioxidant activity (based on DPPH and ABTS scavenging assays). Three fatty acids, palmitic acid, oleic acid and linoleic acid were most abundant and found in all samples. However, extract from fresh shrimp shells showed the highest EPA and DHA content of 10.48 % and 11.62 %, respectively. Astaxanthin-loaded liposomes derived were different in size in that the higher concentration, the larger liposomes produced. Liposomes prepared from 4% (w/v) phospholipid at 50 amplitude gave the highest %DPPH scavenging activity of 79.23.

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Section: The Physical and Chemical Properties Of Astaxanthin-loaded Lsupporting

confidence: 82%

Effects of Shrimp Waste Types and Their Cooking on Properties of Extracted Astaxanthin and Its Characteristics in Liposomes

Darachai¹,

Limpawattana²,

Hawangjoo³

et al. 2019

JFNR

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“…Fluorescein is a dye used as a marker to monitor the absorption of liposomes into tissues. To preserve anti-oxidant stability, liposomes were used as carriers [202][203][204]. Finally, there are numerous other literature reports that describe liposome formation using SCF techniques [17,195,[205][206][207][208][209].…”

Section: Preparation Of Liposomesmentioning

confidence: 99%

Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems

Chakravarty¹,

Famili²,

Nagapudi³

et al. 2019

Pharmaceutics

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Micro- and nano-carrier formulations have been developed as drug delivery systems for active pharmaceutical ingredients (APIs) that suffer from poor physico-chemical, pharmacokinetic, and pharmacodynamic properties. Encapsulating the APIs in such systems can help improve their stability by protecting them from harsh conditions such as light, oxygen, temperature, pH, enzymes, and others. Consequently, the API’s dissolution rate and bioavailability are tremendously improved. Conventional techniques used in the production of these drug carrier formulations have several drawbacks, including thermal and chemical stability of the APIs, excessive use of organic solvents, high residual solvent levels, difficult particle size control and distributions, drug loading-related challenges, and time and energy consumption. This review illustrates how supercritical fluid (SCF) technologies can be superior in controlling the morphology of API particles and in the production of drug carriers due to SCF’s non-toxic, inert, economical, and environmentally friendly properties. The SCF’s advantages, benefits, and various preparation methods are discussed. Drug carrier formulations discussed in this review include microparticles, nanoparticles, polymeric membranes, aerogels, microporous foams, solid lipid nanoparticles, and liposomes.

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“…The sample (10 µL) was diluted with ultrapure water (4 mL) prior to the measurement. The zeta potential was measured by electro photometric light scattering using the capillary cell in the automatic mode of the same instrument [21]. All tests were carried out in triplicate at 25°C and the average values were calculated.…”

Section: Vesicle Size Pdi and Zeta Potentialmentioning

confidence: 99%

Phenylethyl Resorcinol Loaded in Liposomal Cream Formulation for Cosmeceutical Application

Raknam

Pinsuwan

Amnuaikit

2020

JPRI

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Phenylethyl Resorcinol (PR) is a cosmeceutical skin lightening agent and the purpose of this study was to enhance its stability by using liposomal cream formulation which increases local efficacy and safety. Liposome formulation was prepared by modified ethanol injection method, and it contained soy phosphatidyl choline (SPC), cholesterol (CHO), Tween 80 (TW80) and deoxycholic acid (DA) mixed with 2% PR. The physicochemical properties, skin permeation as well as cellular study were evaluated in order to obtain the optimized formulation. The optimized liposome formulation composed of SPC:TW80:DA (84:16:2.5) and exhibited vesicle size, polydispersity index (PDI) and zeta potential of 286.4±8.04 nm, 0.317±0.03 and -39.20±3.85 mV, respectively. Entrapment efficiency (EE) of liposome formulation was 93.55±0.05%. The vesicle was spherical in shape and showed good physicochemical stability for 4 months. The skin permeation study demonstrated that liposome with a negative charge could result in a high PR skin deposition value of 1732.76±216.24 µg/cm2 after 24 h. Cellular study showed that liposome formulation could inhibit melanin content in B16 melanoma cells and enhance cell viability in HaCaT keratinocyte cells. The optimized PR liposome was incorporated in cream and investigated physicochemical properties, stability and skin permeation. Liposomal PR cream showed a good stability and a superior result than PR cream in skin permeation parameters, as well as in tyrosinase inhibition.

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Encapsulation of lutein in liposomes using supercritical carbon dioxide

Cited by 91 publications

References 46 publications

Effects of Shrimp Waste Types and Their Cooking on Properties of Extracted Astaxanthin and Its Characteristics in Liposomes

Effects of Shrimp Waste Types and Their Cooking on Properties of Extracted Astaxanthin and Its Characteristics in Liposomes

Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems

Phenylethyl Resorcinol Loaded in Liposomal Cream Formulation for Cosmeceutical Application

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