In this paper, we present a compositional condition for ensuring safety of a collection of interacting systems modeled by intertriggering hybrid automata (ITHA). ITHA is a modeling formalism for representing multi-agent systems in which each agent is governed by individual dynamics but can also interact with other agents through triggering actions. These triggering actions result in a jump/reset in the state of other agents according to a global resolution function. A sufficient condition for safety of the collection, inspired by responsibility-sensitive safety, is developed in two parts: self-safety relating to the individual dynamics, and responsibility relating to the triggering actions. The condition relies on having an over-approximation method for the resolution function. We further show how such over-approximations can be obtained and improved via communication. We use two examples, a job scheduling task on parallel processors and a highway driving example, throughout the paper to illustrate the concepts. Finally, we provide a comprehensive evaluation on how the proposed condition can be leveraged for several multi-agent control and supervision examples.