Endocrine Control of the Motility of the Male Accessory Genital Organs

Martins, Thales; Valle, José Raymundo Enríquez-del

doi:10.1210/endo-25-1-80

Cited by 37 publications

(27 citation statements)

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“…Figure 2, and if it occurred at all, did so only at relatively high doses ( Figure 3). While this is in general agreement with the findings of Martins & Valle (1939) one difference is that with the drugs which they tested no 'tonic' phase was present after castration while it did occur in some of our experiments. A quantitative comparison of the doses producing a 'tonic' response is shown in Figure 3.…”

Section: Spontanieous Activitysupporting

confidence: 93%

“…Whole vasa from castrated rats invariably exhibited spontaneous activity as noted by Martins & Valle (1939). This activity consisted typically of either bursts of twitches separated by relatively quiescent periods as shown in Figure 1 or of random and intermittent twitches.…”

Section: Spontanieous Activitymentioning

confidence: 74%

“…With higher concentrations the baseline was also elevated so that the response consisted of a maintained 'tonic' contraction with superimposed 'phasic' twitches as described by Martins & Valle (1939) for high concentrations of adrenaline ( Figure 2). …”

Section: Spontanieous Activitymentioning

confidence: 84%

“…The response, which normally consists of a sustained contraction with superimposed rhythmic activity (Waddell, 1916;Macht, 1917), loses the sustained component. This effect can be prevented by testosterone treatment (Martins & Valle, 1939).…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Castration on Neurotransmission in the Rat Vas Deferens

MacDonald

McGrath

1980

British J Pharmacology

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Responses to adrenoceptor agonist drugs and to field stimulation were examined in vasa deferentia from adult castrated or intact rats. Isometric tension was recorded in vitro from whole or transversely bisected vasa. After castration vasa exhibited spontaneous contraction, noradrenaline no longer produced a ‘tonic’ contraction but increased the ‘phasic’ spontaneous activity and salbutamol inhibited spontaneous activity by a β‐adrenoceptor‐mediated mechanism. After castration the ‘adrenergic’ components of the contractile responses to field stimulation were lost whereas ‘noradrenergic’ responses remained, pre‐junctional inhibition of field stimulation‐induced contractions by either endogenous or exogenous activation was lost but adrenergic terminals could still be demonstrated microscopically. Testosterone treatment partially reversed these effects of castration. The relevance of these results to the nature of neurotransmission and to the genesis of spontaneous contraction in the vas deferens is discussed.

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Section: Spontanieous Activitysupporting

confidence: 93%

Section: Spontanieous Activitymentioning

confidence: 74%

Section: Spontanieous Activitymentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

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The Effects of Castration on Neurotransmission in the Rat Vas Deferens

MacDonald

McGrath

1980

British J Pharmacology

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“…HORMONES Some organs and tissues are known to be hormone-dependent. This is the case for the rat vas deferens, as shown by the pioneering work of Martins and Valle (1939) after castration of male rats and other animal species. We have shown that, besides the well-known morphological changes due to the decrease of circulating testosterone, several hormone-induced pharmacological modifications might be related to modifications of calcium translocation (Jurkiewicz et al 1977b, Calixto et al 1983, Aucelio et al 1985, that can be unquestionably ascribed to the striking decrease, of about 90%, of the density of cell membrane calcium channels (Castillo et al 1992).…”

Section: Innervationmentioning

confidence: 86%

Functionomics: the analysis of a postgenomic concept on the basis of pregenomic pharmacological studies in smooth muscle

Jurkiewicz

Caricati‐Neto

Jurkiewicz

2009

An. Acad. Bras. Ciênc.

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The term functionomics (Amin 2003, Neumann et al. 2004 refers to a postgenomic integrated Systems Biology (Attur et al. 2002) using a multidimensional approach for cells, tissues and organs. It considers current or future involvement among genomics, proteomics or metabolomics, including the main factors that cause biological responses and modulation under different conditions. Our objective in the present review is to summarize the contemporary understanding of functionomics of smooth muscle pharmacology, based on the results obtained on the pregenomic era during several years in our laboratory. The present approach is based on the knowledge of the dynamics of the receptor system, which comprises a cascade of phenomena, leading from the drug administration to the final biological response. We will describe several conditions in which the final effect is modified, based on perturbations induced on drug absorption, distribution, metabolism, interaction with receptors and mobilization of second messengers, as well as by interactions with a second receptor system. We will also discuss the gaps that need to be fulfilled in order to obtain a clear and better understanding of the receptor system in smooth muscle, and to narrow the bridge between our knowledge of the function of biological systems, genomics, and other recently introduced areas.

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Histochemical distribution of cholinesterases in the testis, epididymis and vas deferens of the rat

Risley

Skrepetos

1964

Anat. Rec.

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Testes, epididymides, and vasa deferentia of rats were examined for the distribution of cholinesterases using the Koelle thiocholine method. Activity of these enzymes was studied from birth to maturity. Acetylcholinesterase appeared first in Schwann cells of the nerve plexus of the vas deferens and cauda epididymidis at birth. Epithelial cell pseudo-cholinesterase appears in the vas deferens at four days, and an adult distribution is attained at thirty days. Testis, rete testis, ductuli efferentes, and upper caput epididymidis are mainly negative for cholinesterases. In the remainder of the epididymis, three zones of intense epithelial cell reactivity are preceded by regions of lesser intensity. Smooth muscles of the epididymis are negative, but the vas deferens musculature reacts for pseudo-cholinesterase. The nerve plexus is positive for both acetyl-and pseudo-cholinesterase, and is confined to the corpus and cauda epididymidis and vas deferens. The increasing density of the enzymepositive nerves, and the cholinesterase reaction of the musculature distally suggests a probable inhibitory role in the regulation of smooth muscle function in these regions under normal conditions. The absence of an enzyme-positive innervation and the presence of a n enzyme-negative musculature of the caput is correlated with an active rhythmic contractility in this region, which gradually disappears distally.

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Endocrine Control of the Motility of the Male Accessory Genital Organs

Cited by 37 publications

References 0 publications

The Effects of Castration on Neurotransmission in the Rat Vas Deferens

The Effects of Castration on Neurotransmission in the Rat Vas Deferens

Functionomics: the analysis of a postgenomic concept on the basis of pregenomic pharmacological studies in smooth muscle

Histochemical distribution of cholinesterases in the testis, epididymis and vas deferens of the rat

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