Endodermal sinus tumor of the vagina and cervix

Copeland, Larry J.; Sneige, Nour; Ordóñez, Nelson G.; Hancock, Kenneth C.; Gershenson, David M.; Saul, Patton B.; Kavanagh, John J.

doi:10.1002/1097-0142(19850601)55:11<2558::aid-cncr2820551107>3.0.co;2-j

Cited by 100 publications

(34 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diagnosis of an endodermal sinus vaginal tumor mainly relies on a pathological examination, however, comprehensive recognition of the disease has been lacking in the past, for instance, it usually has been misdiagnosed as a clear-cell carcinoma, mesonephric carcinoma, carcinoma of the Woffian duct, undifferentiated sarcoma or botryoid sarcoma, etc [2][3][4][5] .…”

Section: Discussionmentioning

confidence: 99%

Case report of an endodermal sinus vaginal tumor in an infant girl

Sun

Cui

et al. 2007

Chin. J. Clin. Oncol.

View full text Add to dashboard Cite

An female infant patient, aged 8 months old, suffered from irregular colporrhagia for a period of 1 month after which she was taken to our hospital on 30th April, 2003. A pelvic CT examination displayed a 6.5 cm×3.0 cm shadow of a soft-tissue tumor growing longitudinally in her supravaginal uterine area (Fig.1). The density of the shadow was uneven, in which there were irregular low-density foci, an indication of a compression of the colon and bladder and a diffuse boundary between the posterior wall of the urinary bladder and tumor. No abnormalities were found in either kidney or ovary, the liver or gall bladder. Also no obvious lesions were seen on the chest X-ray film, and routine blood and urine laboratory examinations were normal. Her bleeding and clotting time were normal, with a blood level of 13,890 μg/L of serous α-fetoprotein (α-FP or AFP), and hCG of less than 10 IU/L. On the 10th of May, 2003, she received a vaginal smear examination under general anesthesia. The result of a cytopathology examination suggested a botryoid sarcoma cell.On 20th May, 2003, a fragile sphacelus of 3 cm×2 cm prolapsed from the vagina. It was pathologically diagnosed as an endodermal sinus tumor. The results of immunohistochemical studies were as follows: focal AFP (+), HCG (-), S-100 (-) and PAS (+) (Fig.2). The chemotherapeutic PEB regimen was employed, i.e., administration of cisplatin, etoposide and bleomycin (cisplastin 20 mg/m 2 at day 1 to day 3; etoposide 100 mg/m 2 at day 1 to day 3; bleomycin 20 mg/m 2 at day 2, with 21 days per course of treatment). The patient responded to the PEB regimen. After the first course of chemotherapy, the α-FP showed a logarithmic decrease, and after the second course, the α-FP level had returned to normal and remained at this low level. A pelvic CT scan was conducted after the third course of treatment showing that the nodi below the cervix had completely vanished. A vaginal biopsy was performed under general anesthesia, and 4 sphaceli, each with a size of a grain of rice were taken out, at 4 to 5 rough surfaces on the area of the fornix. No other abnormalities were found.A pathological examination of the sphaceli indicated a squamous epithelium and fibrous tissue and, below the epithelium, there were a few inflamed cells and cumulated foam cells. Then one more course of PEB regimen was used for an follow-up treatment. Chemotherapy ceased on the 15th August, 2003 and now the patient is being followed-up. The tumor-free survival of the

show abstract

Section: Discussionmentioning

confidence: 99%

Case report of an endodermal sinus vaginal tumor in an infant girl

Sun

Cui

et al. 2007

Chin. J. Clin. Oncol.

View full text Add to dashboard Cite

show abstract

“…As reported by Pinkerton, the vagina as a primary site accounted for only 2% of MGCT with a pathological diagnosis of EST [3]. EST of the vagina is quite rare and develops exclusively in children under 3 years of age [1,5,6]. Vaginal bleeding is a typical symptom of EST of the vagina, and is often accompanied by a polypoid mass protruding from the vagina [1,10].…”

Section: Discussionmentioning

confidence: 99%

“…This can be attributed to the advent of effective chemotherapeutic agents. Previous reports described that EST of the vagina, like gonadal EST [16][17][18], responded to combination chemotherapy, VAC (VCR, actinomycin-D, and CPA) [5,7], and cisplatin-containing combination chemotherapy that included BVP (cisplatin, bleomycin, and vinblastine sulfate) or PEB (cisplatin, VP-16, and bleomycin) [6,14]. Additionally, the success of chemotherapy has allowed a more conservative surgical approach to these tumors [9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

SUCCESSFUL TREATMENT OF AN ENDODERMAL SINUS TUMOR OF THE VAGINA BY CHEMOTHERAPY ALONE: A Rare Case of an Infant Diagnosed by Pathological Examination of Discharged Tumor Fragment

Tanaka

Ijichi

Yoshikawa

et al. 2006

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

A 7-month-old infant was noted to have vaginal bleeding that was accompanied by a discharged tumor fragment. The histological diagnosis was endodermal sinus tumor. Her serum alpha-fetoprotein (AFP) was increased to 358.7 ng/mL, and magnetic resonance imaging showed a 1.8 x 1.0 cm tumor in the vagina. She received combination chemotherapy with cyclophosphamide, pirarubicin, carboplatin, and etoposide. The tumor in the images disappeared and the serum level of AFP returned to the normal range after 2 cycles. Treatment was complete without surgical or radiological therapy. More than 45 months after the completion of chemotherapy, she is alive without signs of recurrence.

show abstract

“…The morphological features of MGH may closely mimic endometrial adenocarcinomas (EACs) with mucinous differentiation or with microglandular pattern (microglandular adenocarcinoma), especially in limited biopsy specimens [4][5][6][7][8][9]. In addition to careful morphological examination, immunohistochemical studies -including p16, vimentin, estrogen receptor (ER), carcinoembryonic antigen (CEA) and Ki-67 -may be helpful in the differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%