Endometrial dysfunction caused by chronic endometritis: clinical and morphological aspects

Mikhaleva, L.M.; Boltovskaya, M. N.; Mikhalev, S.A.; Бабиченко, И. И.; Vandysheva, R. A.

doi:10.17116/patol201779622-29

Cited by 16 publications

(4 citation statements)

References 7 publications

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“…This percentage reaches 30%-45% in patients who are infertile or experience recurrent pregnancy loss (85)(86)(87)(88)(89)(90). The mechanisms involved in CE-related poor pregnancy outcomes include imbalance in immune cell composition in the endometrium, lower response to steroid hormones, impairment in glycodelin secretion, and altered expression of pinopodes (91)(92)(93)(94).…”

Section: The Endometrial Microbiotamentioning

confidence: 99%

Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes

et al. 2020

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Section: The Endometrial Microbiotamentioning

confidence: 99%

Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes

et al. 2020

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“…Mechanisms underlying the CE‐associated poor obstetric outcomes are not clearly understood. Women with CE have been identified to have endometrial dysfunction characterized by local immunity disorders, lower response to steroid hormones, impairment in glycodelin secretion, and retardation in the development of pinopods (Figure ) …”

Section: Endometrial Microbes and Microbiomementioning

confidence: 99%

Endometrial microbes and microbiome: Recent insights on the inflammatory and immune “players” of the human endometrium

D’Ippolito

Nicuolo

Pontecorvi

et al. 2018

American J Rep Immunol

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In recent years, extended scientific works shed light on the important role played by the endometrium in early pregnancy. This review examines our current knowledge about the delicate balance between microbial and cellular immune agents at endometrial level: All of them might affect endometrial receptivity. In contrast to the classical thinking of human endometrium as a sterile tissue, several recent studies have drawn attention to a resident population of microorganisms, which reaches only a 30% of concordance with those of the cervical‐vaginal flora. At present, the understanding of the microbiome in relation to human reproduction is in its infancy and further studies are needed to clarify the activity of endometrial microbiome and the possible effects of a “reproductive tract dysbiosis” on fertility. Moreover, in the human endometrium, there is a complex system works preventing the risk of infection as well as enabling, when pregnancy occurs, the acceptance of the blastocyst. In this way, the endometrium plays a central role in the uterine immune surveillance. A better understanding of the different agents that may affect endometrial receptivity would improve the diagnosis and treatment of obstetric complications related to defective implantation and placentation.

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“…As the etiology and pathogenesis of chronic endometriosis remain unclear, a diagnostic algorithm is not well established in patients with subclinical chronic endometriosis and infertility. Pregnancy-related dysbiosis and vaginosis roles are not commonly discussed, as well as the roles of chronic endometritis [20,21,22,23] and urogenital infection roles in spontaneous PB occurrence. The aim of our study is to identify the role of urogenital infections in spontaneous PB occurrence through clinical, morphological, PCR and protein analysis evaluation.…”

Section: Urogenital Infection Diagnosis Includes Polymeraze-chain Rea...mentioning

confidence: 99%

“…15 million preterm babies are born yearly in the world [2]. Depending on gestation term PBs are divided into very early PBs (22)(23)(24)(25)(26)(27)6 weeks gestation), early PBs (28-30,6 weeks gestation), PBs (31)(32)(33)6 weeks gestation) and late PBs (34)(35)(36)6 weeks gestation) [3].…”

Section: Introductionmentioning

confidence: 99%

The Role of Urogenital Infections in Spontaneous Preterm Birth

Mikhalev

Radzinsky

Оразов

et al. 2022

Preprint

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Spontaneous preterm birth (PB) results from labor that occurs at 22 to 36 weeks and 6 days (154- 259 days) of gestation. The frequency of PB is 5-18% of all births. Objective: our study aims to determine the role of urogenital infections in spontaneous PB occurrence. Methods: 102 pregnant women aged 22-45 years participated in the study, 90 of which developed premature birth (22-36.6 weeks gestation, spontaneous pregnancy group) and 12 with normal birth (at 38-41 week-gestation). The patients were evaluated regarding their anamnesis (gynecological diseases, history of previous pregnancies, age and gestation), presence of urogenital infections (via expanded polymerase-chain reaction testing – PCR), inflammatory changes in the uteroplacental complex (histological evaluation), and compared results between the two groups. Results: conditionally pathogenic flora was detected in the uterus of every second patient with spontaneous PB, uterine body dysbiosis was seen three times more often, bacterial vaginosis was seen 11 times more often in PB group than the control group. Utero-placental complex inflammatory changes were detected in 36-50% of patients with spontaneous PB and were accompanied by chronic placental insufficiency, confirmed both pathomorphologically and via protein metabolism assessment. Conclusions: our results support the assumption that urogenital infections play a role in the development of spontaneous PB.

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Endometrial dysfunction caused by chronic endometritis: clinical and morphological aspects

Cited by 16 publications

References 7 publications

Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes

Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes

Endometrial microbes and microbiome: Recent insights on the inflammatory and immune “players” of the human endometrium

The Role of Urogenital Infections in Spontaneous Preterm Birth

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