Endometrial metastases in breast cancer: a rare event

Aksahin, Arzu; Colak, Dilsen; Güreli, Mustafa; Aykaş, Fatma; Mutlu, Hasan

doi:10.1007/s00404-012-2651-5

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…There are many diagnostic problems in confirming endometrial metastasis. Some criteria that must be met are: (1) Histopathologic features of the metastatic tumor should be identical to the original neoplasm, with no detection of coexisting primary neoplastic changes in the destination organ (uterus) [ 5 , 6 , 11 , 12 ]; (2) In known breast cancer patients, a hormone-induced (tamoxifen) endometrial neoplasm should be excluded; and (3) A consistent IHC is necessary to determine the original tumor (e.g., GCDFP15 and mammaglobin are specific and differentiating markers in favor of breast origin rather than primary endometrial carcinoma). GI malignancies usually express CK20 and CDx2 whereas endometrial and breast carcinoma are CK7-positive and CK20-negative.…”

Section: Discussionmentioning

confidence: 99%

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Endometrial Metastasis from Ductal Breast Carcinoma: A Case Report with Literature Review

2018

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Patient: Female, 51Final Diagnosis: Endometrial metastasis from ductal breast carcinonomaSymptoms: Abnormal uterine bleeding • menorrhagiaMedication: —Clinical Procedure: Dilatation and curettage (D&C) • tissue diagnosis of the endometriumSpecialty: Obstetrics and GynecologyObjective:Unusual clinical courseBackground:There are few reports of breast cancer cases with uterine metastases; among them, myometrium is more frequently involved than endometrium. The majority of breast cancer metastases to endometrium are lobular type, and there have been only 5 reported cases of ductal type since 1984. Here, we describe a new case of invasive ductal carcinoma with metastases to endometrium and isolated presentation of abnormal uterine bleeding, in addition to reviewing the existing literature on other similar cases.Case Report:The patient was a 51-year-old Persian woman with no remarkable past medical or family history of cancer, who presented with a 6-month complaint of menorrhagia to our gynecology clinic. Diagnostic studies including trans-vaginal ultrasonography, pathological examination of endometrial curettage specimen, immunohistochemistry findings, and X-plane and magnetic resonance mammography, and breast core-needle biopsy revealed invasive ductal breast carcinoma as the origin of the endometrial metastasis.Conclusions:Abnormal uterine bleeding in a premenopausal patient should alert clinicians to the possibility of secondary as well as primary neoplasms. It is necessary to differentiate a metastatic tumor from a primary one, since the treatment and prognosis are completely different.

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Section: Discussionmentioning

confidence: 99%

“…GI malignancies usually express CK20 and CDx2 whereas endometrial and breast carcinoma are CK7-positive and CK20-negative. In breast cancers, those with tubule formation and positive reaction with E-Cadherin are ductal type [ 6 , 12 ]. Our patient’s IHC results were completely compatible with the prototype pattern of IDC.…”

Section: Discussionmentioning

confidence: 99%