Endometrioid Adenocarcinoma in an Extrauterine Adenomyoma

Ulm, Michael; Robins, David; Thorpe, Edwin M.; Reed, Mark

doi:10.1097/aog.0000000000000391

Cited by 7 publications

(14 citation statements)

References 21 publications

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“…[ 42 ] Caecum, descending colon and mesocolon 39 Total hysterectomy with LSO, RSO for endometriosis Right lower quadrant pain USG,CT Ovarian endometriosis Colonoscopic and laparoscopic resection M, B, C 26 Ulm et al. [ 43 ] 3 cm, left round ligament 49 Metromenorrhagia CT inguinal adenopathy TAH with BSO and lymph node dissection M 27 Torres et al. [ 44 ] 4 cm, right broad ligament 58 Post menopausal bleeding USG,CT malignancy Total Robotic hysterectomy with bilateral salpingo- oophorectomy M 28 Sopha et al.…”

Section: Discussionmentioning

confidence: 99%

“…Ulm et al. [ 43 ] reported focal endometrioid adenocarcinoma in extrauterine adenomyoma (round ligament) with concurrent stage 1 uterine endometrioid adenocarcinoma. Rahilly et al.…”

Section: Discussionmentioning

confidence: 99%

“…Torres et al [44] reported clear cell adenocarcinoma in a case of broad ligament adenomyoma. Ulm et al [43] reported focal endometrioid adenocarcinoma in extrauterine adenomyoma (round ligament) with concurrent stage 1 uterine endometrioid adenocarcinoma. Rahilly et al [23] reported a concurrent occurrence of ovarian adenomyoma with ovarian endometrioid carcinoma and uterine endometrial cancer.…”

Section: Discussionmentioning

confidence: 99%

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A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

Liberale

Surace

Lilleri

et al. 2020

Heliyon

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Extrauterine adenomyoma is a rare type of benign tumor, characterized by nodular aggregate of smooth muscle, endometrial glands and endometrial stroma, arising outside the uterus. In this study we describe a case of primary ovarian adenomyoma associated with endometriotic cysts with contralateral serous borderline tumor in a 40-year-old woman and we highlight how preoperative exams could lead to the suspicious of invasive cancer. We provide a review of the literature, analyzing all cases of extrauterine adenomyoma published so far, classifying them on the basis of pathogenetic theories proposed, localization of the lesion, imaging modalities and treatment adopted.

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Section: Discussionmentioning

confidence: 99%

“…Ulm et al. [ 43 ] reported focal endometrioid adenocarcinoma in extrauterine adenomyoma (round ligament) with concurrent stage 1 uterine endometrioid adenocarcinoma. Rahilly et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

Liberale

Surace

Lilleri

et al. 2020

Heliyon

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“…Similar lesions were described in the small intestine [101] and the nervous system [102]. Extrauterine adenomyomas may arise from the ovary [103], the ovarian ligament [104], the broad ligament [105] or the round ligament [106] and are not connected to the uterus. Rokitansky's early description may be an instance of an adenomyomatous polyp [21].…”

Section: Müllerianosis and Mixed Endometrial-myometrial Lesionsmentioning

confidence: 64%

The History of the Discovery of Ectopic Epithelial Cells in Lower Peritoneal Organs: The So-Called Mucosal Invasion

2021

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Through microscopy, early researchers identified the epithelium on the inner surfaces of the uterus, cervix and Fallopian tubes. The identification of ectopic epithelium was gradual, starting from the gross pathology study of unusual cystic lesions. Towards the end of the nineteenth century, attention focused on the epithelium as a critical component. The term ‘adenomyoma’ was coined around eighteen eighty to designate the majority of mucosa-containing lesions. Several theories were advanced to explain its aetiology. In the main, lesions were considered to arise from invasion from uterine epithelium; implantation of endometrium through retrograde menstruation; hematogenous or lymphatic spread; or from embryonic remnants. Although initially widely rejected, around 1920, an almost unanimous consensus formed on the endometrial nature of epithelial invasions. During the following years, adenomyosis and endometriosis came to be used to distinguished lesions within or outside the uterus. Adenomyosis was attributed to direct infiltration of uterine mucosa into the myometrium, and endometriosis to the implantation of endometrial cells and stroma into the peritoneal cavity through retrograde menstruation. Around the same time, ovarian lesions, initially described as ovarian hematomas or chocolate cysts, were regarded as a form of endometriosis. Three variants of endometriosis were thus described: superficial peritoneal, deep nodular and ovarian endometriomas. Ectopic epithelium has long been recognised as having similarities to tubal, or cervical epithelium. Lesions containing mixed epithelium are often termed Müllerianosis. This article demonstrates the stepwise evolution of knowledge, the role of the pioneers and the difficulties that needed to be overcome. It also demonstrates the value of collaboration and the inter-connected nature of the scientific endeavour.

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“…Finally, it should point out for our that it seems no causal relationship existing between extrauterine adenomyoma of the lesser omentum and stomach adenocarcinoma. Previous reports have shown that extrauterine adenomyoma could also undergo malignant transformation, such as to endometrioid adenocarcinoma [7,24] or to clear cell carcinoma. [20,38] So far, there has been no report of the malignant transformation of extrauterine adenomyoma into endometrial stromal sarcoma and leiomyosarcoma, but it is possible in theory.…”

Section: Discussionmentioning

confidence: 99%

Extrauterine adenomyoma of the lesser omentum: A case report and review of the literature

Chen

Deng

Zhao³

et al. 2022

Medicine

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Rationale: The extrauterine adenomyoma is rare and it is extremely rare outside the pelvic cavity. Herein, we reported the first case of a single extrauterine adenomyoma occurring in the lesser omentum.Patients concerns: This case involved a 55-year-old woman who had undergone subtotal gastrectomy and omentectomy for gastric carcinoma. During postoperational pathological examination, 1 lymph node-like mass was coincidentally found in the lesser omentum. The patient had a history of hysterectomy for uterine leiomyoma 8 years ago.Diagnoses: The resected 17 "lymph nodes" from the lesser omentum were routinely checked for possible metastasis of gastric carcinoma. One of lymph node-like mass was microscopically showed that it was composed of benign smooth muscle components, endometrial glands and stroma by HE staining. Therefore, adenomyoma was initially considered.Interventions: The lymph node-like mass was removed together with the lesser omentum during the subtotal gastrectomy and omentectomy for gastric carcinoma. No special intervention was performed for the adenomyoma.Outcomes: Immunohistochemical staining confirmed that smooth muscle tissue was diffusely and strongly positive for Desmin, smooth muscle actin, estrogen receptor, and progesterone receptor, and negative for CD117, Dog-1, S100, and CD34. Endometrial glands and stroma were positive for estrogen receptor and progesterone receptor, and the endometrium interstitium was also positive for CD10. The final diagnosis of extrauterine adenomyoma occurring in the lesser omentum was established.Lessons: So far, to the best of our knowledge, total 53 cases of extrauterine adenomyoma have been reported in 45 English reports. The most common location for a single mass was pelvic cavity (37 cases), but rarely outside the pelvic cavity. This is the first case of a single extrauterine adenomyoma occurring in the lesser omentum.Abbreviations: CD10 = common acute lymphoblastic leukemia antigen, CD117 = stem cell growth factor receptor, CD34 = hematopoietic progenitor cell antigen, ER = estrogen receptor, PR = progesterone receptor, SMA = smooth muscle actin.

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Endometrioid Adenocarcinoma in an Extrauterine Adenomyoma

Abstract: Stage 1 endometrioid adenocarcinoma with concurrent, noninvasive, focal involvement in an extrauterine adenomyoma represents a secondary site and does not alter disease stage.

Cited by 7 publications

References 21 publications

A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

A rare case of ovarian adenomyoma mimicking primary invasive ovarian cancer with a contralateral serous borderline ovarian tumor: A case report and review of the literature

The History of the Discovery of Ectopic Epithelial Cells in Lower Peritoneal Organs: The So-Called Mucosal Invasion

Extrauterine adenomyoma of the lesser omentum: A case report and review of the literature

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