Endoscopic diagnosis of a pineal papillary glioneuronal tumor with extensive ventricular involvement: Case report with review of literature

Husain, Nuzhat; Husain, Mazhar

doi:10.4103/0028-3886.59481

Cited by 19 publications

(12 citation statements)

References 15 publications

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“…The observed degenerative changes were previously reported with variable frequencies. 4 Immunohistochemically, the biphasic pattern appreciated in ordinary sections was reflected by positive immunostaining for both glial and neuronal markers, which was seen in respective glial and neuronal areas without dual expression. Similar results were reported by a recent study that observed either astrocytic or neuronal differentiation, without any hybrid cells.…”

Section: Discussionmentioning

confidence: 99%

Papillary Glioneuronal Tumor

Abdelzaher¹,

Eshra

Zamzam

2015

Neurosurgery Quarterly

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Section: Discussionmentioning

confidence: 99%

Papillary Glioneuronal Tumor

Abdelzaher¹,

Eshra

Zamzam

2015

Neurosurgery Quarterly

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“…To date, 89 cases of PGNT have been reported in the English literature . Radiologically, most of these cases showed a cystic mass with a mural nodule in the periventricular location.…”

Section: Discussionmentioning

confidence: 99%

Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

et al. 2014

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Papillary glioneuronal tumor (PGNT) is a rare type of primary brain tumor. Although PGNT has traditionally been defined as a clinically indolent neoplasm, several cases with high proliferative activity and tumor recurrence have recently been reported. We report a case of PGNT in a 12-year-old boy who presented with epilepsy and harbored a 64 mm cystic tumor with a high proliferative component in the right temporal lobe. (11) C-methionine positron emission tomography (PET) showed high uptake in the solid mass. Gross total resection of the tumor mass was achieved and the patient became seizure-free without any neurological deficits. Histologically, the tumor contained two distinct areas of a vasocentric papilliform structure and a desmoplastic component. Minigemistocytic cells and small necrotic regions were observed adjacent to the pseudopapillae. Immunohistochemical analyses revealed both glial and neuronal differentiation. The Ki-67 proliferation index was high (14%) in the area corresponding to the high uptake region in the (11) C-methionine PET. No tumor recurrence was observed 20 months after surgery. High proliferative PGNTs are rare and to our knowledge this is only the third pediatric case of PGNT with atypical features reported in the literature. Hence, we here review the reported cases of PGNT and discuss the clinical, radiological and histological features of this malignancy.

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“…Husain et al recently reported a case involving a 4-year-old child with obstructive hydrocephalus with a tumor involving the pineal gland and the ventricular system (Table 1) [8] without anaplastic features or high vascularity. It seems that glioneuronal tumors in the pineal gland may occur in any group, with older patients having a greater predilection for anaplasic features (Table 2), however the number of cases is too small to postulate this trend.…”

Section: Discussionmentioning

confidence: 99%

Malignant papillary glioneuronal tumor of the pineal gland: Case presentation and literature review of a distinct entity

2013

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Patient:Male, 58Final Diagnosis:Papillary glioneuronal tumor of the pineal glandSymptoms:Headache • loss of memory • hydrocephalusMedication:—Clinical Procedure:—Specialty:Oncology • neurology • neurosurgeryObjective:Rare diseaseBackground:The authors report the third case of a rare papillary glioneuronal tumor of the pineal gland and only the second case reported with anaplastic features in this particular location. The authors also review the literature of papillary glioneuronal tumors.Case Report:Our patient is a 58-year-old Caucasian male who presented with diffuse headaches and loss of short-term memory. There were no deficits on physical exam. MRI Brain was performed demonstrating a large heterogeneously enhancing mass within the pineal gland causing obstructive hydrocephalus. He was taken to the operating room for supracerebellar-infratentorial approach for biopsy of the mass using neuronavigation. He required an endoscopic third ventriculostomy post-operatively for worsening hydrocephalus. Pathology demonstrated a rare malignant papillary glioneuronal tumor. It was recommended that patient undergo chemotherapy and radiation, however he refused treatment. He died six months after his initial diagnosis due to a condition unrelated to his intracranial tumor.Conclusions:This is an unusually rare tumor of the pineal gland, with only one other malignant case noted in this location. We review the literature of this rare entity that should be considered on the differential diagnosis of a pineal gland mass.

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Endoscopic diagnosis of a pineal papillary glioneuronal tumor with extensive ventricular involvement: Case report with review of literature

Cited by 19 publications

References 15 publications

Papillary Glioneuronal Tumor

Papillary Glioneuronal Tumor

Papillary glioneuronal tumor with a high proliferative component and minigemistocytes in a child

Malignant papillary glioneuronal tumor of the pineal gland: Case presentation and literature review of a distinct entity

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