Endothelial Dysfunction and Intestinal Dysbiosis in Patients with Non-Alcoholic Steatohepatitis and Type 2 Diabetes Mellitus

Sirchak, Ye.S.; Грига, В. И.; Petrichko, O.I.; Oleksyk, О.T.; Pichkar, Yo. I.

doi:10.26693/jmbs05.01.192

Cited by 1 publication

(1 citation statement)

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“…According to the results of numerous experimental and clinical studies in recent years, the dominant place in the pathogenesis of the development of cardiovascular system lesions belongs to the violation of endothelial dysfunction [3]. Among them, there is the formation of pro-inflammatory, prothrombotic, and vasoconstrictor substances on the one hand and the imbalance of vasodilating, antiinflammatory, antiatherogenic, antiproliferative factors on the other hand [4]. Endothelin-1 polypeptide is one of the most important regulators of the functional state of vascular endothelium, which determines the vasoactive effect.…”

Section: Introductionmentioning

confidence: 99%

State of endothelial function, lipid spectrum and features of coronary vessels structure of rats with obesity and insulin resistance under iodine deficiency conditions

Todoriv¹,

Bagriy²,

Voronych-Semchenko³

2021

Fiziol Zh

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The aim of the study was to investigate the changes of endothelin-1 content, blood lipid spectrum parameters, structural features of coronary vessels of rats with insulin resistance and obesity under conditions of adequate iodine supply and iodine deficiency. For the modeling of insulin resistance, rats were kept on high-fructose, obesity – high-calorie, iodine deficiency – iodine deficiency diets. It was found that the development of insulin resistance, obesity and iodine deficiency was accompanied by an increase of endothelin-1 level in 2.41, 2.31 times and at 80.17% in blood serum, relative to the data in intact animals. Insulin resistance and obesity under conditions of limited iodine supply leads to the significant changes in endothelial dysfunction (increase in the level of endothelin-1 in 3.02 and 2.50 times relative to control and at 67.38 and 39.40% – relative to mono iodine deficiency) and dyslipidemia (increase in the atherogenic factor at 48.08% – 4.20 times relative to isolated insulin resistance, obesity and iodine deficiency). Such changes were consistent with the structural violations. In insulin-resistant animals focal unevenness of the outer and inner contours, their uneven thickness, areas of homogeneous enlightenment were observed under the conditions of iodine deficiency in the arterioles and minor arteries of the myocardium. In obese animals under the conditions of iodine deficiency, the vessels of the microcirculatory bed were dilated and overflown with erythrocytes. Endotheliocytes with nuclei elongated along the wall, in some places there is a swelling of the cytoplasm of endotheliocytes. In the wall of minor arteries there are transparent vacuoles, areas of homogeneous eosinophilia, which are caused by the accumulation of glycoproteins. Thus, the development of insulin resistance and obesity in iodine deficiency is accompanied by more significant changes in endothelial function and an increase in proatherogenic fractions in the blood lipid spectrum, as evidenced by changes in the structural organization of myocardial vessels than with proper iodine supply.

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Section: Introductionmentioning

confidence: 99%