Endothelial dysfunction and melatonin

Abstract

2. Albrektson M., Hedström L., Bergh H. Recurrent aphthous stomatitis and pain management with low-level laser therapy: A randomized controlled trial. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014;117(5):590-594. doi:10.1016/j.oooo.2014 3. Chavan M., Jain H., Diwan N., Khedkar S., Shete A., Durkar S. The item offers independent and referential data on the role that melatonin plays in the regulation of endothelial function. There is also an analysis of the impact that melatonin has on cardiovascular system activity, which is related to restriction of arterial hypertension, atherosclerosis, metabolic syndrome with hyperlipidemia and diabetes mellitus, and enhanced platelet hemostasis. There is a discussion of a set of mechanisms on the cellular level (counteraction to oxidative stress) as well as on the systemic level -psychotropic and chronotropic effects of melatonin.

The Impact of Melatonin and its Agonist on Endothelin-1 Reactivity in Isolated Aorta in Continuous Light and Pinealectomized Rats

“…Because of its direct vasodilatory effect, melatonin can reduce endothelial dysfunction (Arushanyan and Shchetinin 2015). The new finding of the current study indicated that the administration of melatonin against continuous light significantly changed the dose response of ET-1 compared with ET-1 DRC in LED exposure rats.…”

“…One of these is NO, which relaxes the tension in vascular smooth muscle and prevents hypertension from arising due to the inhibition of the NO-producing eNOS. Furthermore, melatonin triggers the release of the vasodilators bradykinin and prostacyclin from platelet cells into the bloodstream while assuring the accumulation of calcium ions in the vascular endothelium (Pogan, Bissonnette et al 2002, Paulis, Pechanova et al 2010, Arushanyan and Shchetinin 2015.…”

Influence of melatonin on the processes of hemocoagulation, lipoperoxidation and disturbance of the urinary kidneys function in the chronic chromium compounds intoxication

“…В современной литературе широко изучается роль мелатонина практически во всех процессах жизнедеятельности, влияние на сон, деятельность сердечно-сосудистой, эндокринной, иммунной системы, а также системы гемостаза [12,13]. Выраженные мембранопротекторные свойства мелаксена обусловлены его выраженным антиоксидантным действием [13,14].…”

Features of highly specific factors of endothelial dysfunction and indicators of the hemostatic system and lipid metabolism in rats under various experimental conditions

“…Early metabolic changes in the lipid spectrum, characterized by an increase in the fractions of atherogenic lipoproteins and the AC, potentiate the formation of CECs. Multiparametric approaches can be used to evaluate the effectiveness of new pathogenetically and sanogenetically based methods for correcting endothelial dysfunction [15,16]. In the analysis of the main indices of lipid metabolism, Group IV showed significantly higher concentrations of TC (2.65±0.23 mmol/L) and LDL-c (1.77±0.21 mmol/L) than Group I (1.76±0.15 and 0.91±0.12 mmol/L, respectively; p=0.001 for both).…”