Endothelial Dysfunction in Preeclampsia

Var, Ahmet; Yıldırım, Yasemin; Onur, Ece; Kuşçu, Naci Kemal; Uyanık, Bekir Sami; Goktalay, Kayhan; Güvenç, Yeşim

doi:10.1159/000074824

Cited by 49 publications

(11 citation statements)

References 12 publications

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“…In this study, significantly lower levels of NO were observed in the pre‐eclamptic women when compared with control group in accordance with the findings of Var et al 16 . However, Norris et al 17 .…”

Section: Discussionsupporting

confidence: 92%

ORIGINAL ARTICLE: Role of Inflammatory Cytokines and eNOS Gene Polymorphism in Pathophysiology of Pre‐Eclampsia

Singh

Sharma

Chitra

et al. 2010

American J Rep Immunol

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Section: Discussionsupporting

confidence: 92%

ORIGINAL ARTICLE: Role of Inflammatory Cytokines and eNOS Gene Polymorphism in Pathophysiology of Pre‐Eclampsia

Singh

Sharma

Chitra

et al. 2010

American J Rep Immunol

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“…This hypoperfusion induced ischaemic injury to hepatic cells and other organs cause increased release of intracellular LDH to circulation. [9][10][11][12][13][14][15][16][17] In the present study, increased serum LDH level in preeclamptic women than control women are attributed to these facts. Moreover, the progressively increased LDH level in severe preeclampsia indicates progression of cellular injury with severity of this disorder.…”

Section: Discussionmentioning

confidence: 82%

LDH as a prognostic marker in hypertensive pregnancy

Talwar

Kondareddy

Shree

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Pregnancy induced hypertension (PIH) is a global problem with a 5-15% incidence rate in India and complicating 10-17% of all pregnancies. These are multisystem disorders and lead to a lot of cellular death. LDH is an intracellular enzyme and its level is increased in these women due to cellular death. So, serum LDH levels can be used to assess the extent of cellular death and thereby the severity of disease in this group of women. The objective of the study was to correlate the severity of the disease, maternal and perinatal outcome with Lactic Dehydrogenase (LDH) levels in serum in patients of preeclampsia and eclampsia.Methods: A prospective comparative study was conducted in the department of Obstetrics and Gynecology, JSS Medical Hospital, Mysore.Results: LDH levels were significantly elevated in women with preeclampsia and eclampsia (<0.001). Higher LDH levels had significant correlation with high blood pressure (P <0.10) as well as poor maternal and perinatal outcome.Conclusions: High serum LDH levels correlate well with the severity of the disease and poor outcomes in patients of preeclampsia and eclampsia.

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“…High levels of homocysteine are associated with higher risks of cardiovascular diseases (12). The mechanism is poorly understood, but high homocysteine levels seem to alter endothelial nitric oxide secretions, thereby inducing hypertension and ischemia (13). During a normal pregnancy, plasma homocysteine concentrations will decrease (5).…”

Section: Introductionmentioning

confidence: 99%

The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia

2016

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IntroductionIncreased plasma homocysteine may be associated with adverse pregnancy outcomes, such as preeclampsia. The aim of this study was to determine the plasma homocysteine, serum folate, and vitamin B12 levels in preeclamptic pregnant women.MethodsThis case-control study was conducted in 2016 in Ahwaz on 51 pregnant women with preeclampsia and 51 healthy pregnant women of the same gestational age, who served as controls. The case group also was subdivided into severe and non-severe preeclampsia. Patients’ data were collected through a questionnaire and medical records. Serum homocysteine, folic acid, and vitamin B12 were analyzed using chemiluminescent assay. The results were compared between two groups. Statistical analyses were done using IBM-SPSS 20.0. A Kolmogorov-Smirnov test, independent samples t-test, Mann-Whitney test, and Chi-square test were used for data analysis.ResultsNo different demographic characteristics were found among the groups. Pregnant women complicated with preeclampsia displayed significantly higher serum homocysteine levels (p < 0.001) and lower serum folate (p = 0.005) and vitamin B12 levels (p < 0.001) compared to controls. A statistically significant inverse correlation was evident between serum homocysteine and serum folate levels in preeclamptic patients (p = 0.005; r = −0.389). In addition, an inverse correlation was identified between homocysteine and serum vitamin B12, but it was not statistically significant (p = 0.160; r = −0.200). Significant differences occurred in serum homocysteine and folate levels between the severe and non-severe subgroups (p < 0.001, p < 0.001).ConclusionWomen complicated with preeclampsia displayed higher maternal serum homocysteine and lower serum folate and vitamin B12. Further studies are needed to confirm if the prescription of folic acid and vitamin B12 in women with a deficiency of these vitamins could decrease the level of serum homocysteine and, therefore, reduce the risk of preeclampsia or, if it occurred, its severity.

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Endothelial Dysfunction in Preeclampsia

Cited by 49 publications

References 12 publications

ORIGINAL ARTICLE: Role of Inflammatory Cytokines and eNOS Gene Polymorphism in Pathophysiology of Pre‐Eclampsia

ORIGINAL ARTICLE: Role of Inflammatory Cytokines and eNOS Gene Polymorphism in Pathophysiology of Pre‐Eclampsia

LDH as a prognostic marker in hypertensive pregnancy

The evaluation of serum homocysteine, folic acid, and vitamin B12 in patients complicated with preeclampsia

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