Endothelial nitric oxide synthase Glu298Asp, 4b/a, and T‐786C polymorphisms in type 2 diabetic retinopathy

Ezzidi, Intissar; Mtiraoui, Nabil; Mohamed, Manel Ben Hadj; Mahjoub, Touhami; Kacem, M.; Almawi, Wassim Y.

doi:10.1111/j.1365-2265.2007.03089.x

Cited by 30 publications

(19 citation statements)

References 22 publications

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“…The NOS3 gene is located in the 7q35-36 region of chromosome 7 and the genetic polymorphism with a great clinical relevance is the 27 bp-VNTR 4b/a intron 4 [40]. In addition, NO produced by endothelial and epithelial cells, also modulates the regulation of vascular endothelial growth factor and is possibly associated to increase in processes of invasiveness and metastasis [41].…”

Section: Reactive Nitrogen Speciesmentioning

confidence: 99%

Microenvironment in Vagina as a Key-Player on Cervical Cancer: Interaction of Polymorphic Genetic Variants and Vaginal Microbiome as Co-Factors

Matos¹,

Silva²,

Medeiros³

et al. 2018

Cervical Cancer - Screening, Treatment and Prevention - Universal Protocols for Ultimate Control

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Current knowledge point to persistence of risk factors for the development of cervical intraepithelial neoplasia. The infection with a high-risk oncogenic Human Papillomavirus (HPV) subtypes, most commonly 16 and 18, is a necessary, although not sufficient, condition for development of invasive cervical cancer (ICC) and its precancerous precursor, cervical intra-epithelial neoplasia (CIN). It has been suggested that CIN disease severity and the diversity of vaginal microbiota are associated and this may determine viral persistence and disease behaviour. Our work focuses on the genetic variability associated to the modulation of genotoxicity induced by vaginal microbiota diversity. Relatively little is known about the mechanisms associated with clearance or persistence of HPV infection, therefore we hypothesized that may be under the influence of the genetic background.

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Section: Reactive Nitrogen Speciesmentioning

confidence: 99%

Microenvironment in Vagina as a Key-Player on Cervical Cancer: Interaction of Polymorphic Genetic Variants and Vaginal Microbiome as Co-Factors

Matos¹,

Silva²,

Medeiros³

et al. 2018

Cervical Cancer - Screening, Treatment and Prevention - Universal Protocols for Ultimate Control

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“…It was demonstrated in previous studies that the T/C (-786) eNOS polymorphism is associated with diabetic nephropathy and end stage renal disease [16,36], diabetic retinopathy and diabetic macula edema [38,39], albuminuria [40], rheumatoid arthritis [41], acute coronary syndrome [42,43], coronary artery disease [44] essential and arterial hypertension [45,46], inflammation and atherosclerosis [37,47]. In our study, significant results appeared for the T/C eNOS polymorphism in the comparison with genotype's frequencies between the healthy individuals and the groups (DM, DN, NDRD respectively) of diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

et al. 2012

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A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism and the T/C (−786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes.

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“…Тем не менее в некоторых исследованиях была выявлена ассоциация генотипа гомозиготы по аллели Т с инсулинорезистентностью у пациентов с СД2 типа и кар-диомиопатиями среди европейцев [6] и японцев [7], а также с повышенным уровнем глюкозы в крови у жителей Саудовской Аравии [8]. Роль уровня NO, в частности, имеет большое значение в вероятности наступления таких осложнений СД2, как нефропатия [9,10], ретинопа-тия [11], кардиомиопатия [12].…”

Section: эндокринологияunclassified

Pharmacoeconomical Approval of Genotyping Eligibility in Patients With Diabetes Mellitus Type 2 Taking Metformin

et al. 2016

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Эффективность сахароснижающей терапии зависит не только от своевременного начала приема пероральных сахаросни-жающих препаратов, но и от генетических особенностей организма пациента. Оценка значения однонуклеотидных поли-морфизмов генов для прогнозирования эффективности терапии является перспективным направлением и подтверждает-ся с позиции фармакоэкономики. На базе клинической больницы им. Н.А. Семашко было обследовано 89 пациентов с впервые выявленным сахарным диабетом 2-го типа и 80 лиц без нарушений углеводного обмена. В результате проведен-ных исследований было выявлено две группы пациентов: имеющие «фенотип провала», которым необходимы высокие дозы препарата (с развитием побочных эффектов) или его замена для достижения необходимого терапевтического эффекта, и имеющие «фенотип ответа». Анализ «затраты -эффективность» свидетельствует о том, что процедура геноти-пирования перед назначением метформина с целью выявления фенотипа «ответа» позволяет уменьшить затраты на единицу эффективности сахароснижающего препарата метформин. PHARMACOECONOMICAL APPROVAL OF GENOTYPING ELIGIBILITY IN PATIENTS WITH DIABETES MELLITUS TYPE 2 TAKING METFORMINEffectiveness of sugar-lowering therapy depends on both betimes started therapy and genetically defined features of a patient. Single nucleotide polymorphism of genes may be perspective and approved by pharmacoeconomical analyses. We observed 89 patients with newly diagnosed diabetes mellitus type 2 and 80 subjects without impaired glucose metabolism. We found out 2 types of patients-with "response phenotype" and "fail phenotype". CER showed that genotyping before prescribing metformin in order to find out "fail phenotype" to avoid lack of effectiveness could reduce expenses.

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Endothelial nitric oxide synthase Glu298Asp, 4b/a, and T‐786C polymorphisms in type 2 diabetic retinopathy

Abstract: This study identifies genetic variation at the eNOS locus as genetic risk factor for diabetic retinopathy, which may serve as a useful marker of increased susceptibility to the risk of retinopathy.

Cited by 30 publications

References 22 publications

Microenvironment in Vagina as a Key-Player on Cervical Cancer: Interaction of Polymorphic Genetic Variants and Vaginal Microbiome as Co-Factors

Microenvironment in Vagina as a Key-Player on Cervical Cancer: Interaction of Polymorphic Genetic Variants and Vaginal Microbiome as Co-Factors

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

Pharmacoeconomical Approval of Genotyping Eligibility in Patients With Diabetes Mellitus Type 2 Taking Metformin

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