Endothelin-1 in the Human Prostate: Tissue Levels, Source of Production and Isometric Tension Studies

Langenstroer, Peter; Tang, Rui; Shapiro, Ellen; Divish, Barbara J.; Opgenorth, Terry J.; Lepor, Herbert

doi:10.1016/s0022-5347(17)35534-9

Cited by 108 publications

(62 citation statements)

References 18 publications

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“…Endothelins cause the contraction of human prostate stroma, 38 with some researchers reporting involvement of endothelin ET A receptors and/or ET B receptors. 39,40 Endothelins have also been reported to mediate contractions of the rat prostate via endothelin ET A receptors 34 while having no effect on resting prostatic smooth muscle tone in the guinea-pig prostate but enhancing neuromuscular transmission to the smooth muscle through activation of endothelin ET A receptors.…”

Section: Animal Prostate Models Of Human Prostate Contractilitymentioning

confidence: 99%

“…Thus, endothelin-1 is a potent stimulator of prostatic contractions 38,40 and a potent stimulator of inositol trisphosphate accumulation in prostatic stromal cells. 98 Acetylcholine has been shown to have either no direct contractile effect in human prostatic tissue (although it potentiated responses to exogenous noradrenaline) 9 or to elicit small contractions.…”

Section: Cultured Cell Models Of Human Prostate Contractilitymentioning

confidence: 99%

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Current models of human prostate contractility

Haynes

Ventura

2005

Clin Exp Pharma Physio

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SUMMARY1. The human prostate is a compact gland contributing to seminal fluid. With increasing age, most humans will develop benign prostatic hyperplasia, a condition of prostatic enlargement and contractility that leads to occlusion of the urethra. Over many years, investigators have used a variety of animal and cell culture models to elucidate some of the contractile and proliferative mechanisms that may be associated with the development of this condition.2. This review briefly assesses the current state of knowledge of the mechanisms underlying human prostatic contractility and compares it with that of animal and cell culture models. It is not intended as a comprehensive methodological review, nor is it intended to indicate our preferences for either model. Our aim is to correlate findings from animal and cell culture models with the current understanding of human prostate contractility.3. We hope that the present review will increase awareness of the suitability of the current models in developing our understanding of benign prostatic hyperplasia.

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Section: Animal Prostate Models Of Human Prostate Contractilitymentioning

confidence: 99%

Section: Cultured Cell Models Of Human Prostate Contractilitymentioning

confidence: 99%

Current models of human prostate contractility

Haynes

Ventura

2005

Clin Exp Pharma Physio

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“…Endothelin-1 (ET-1), a 21 amino acid peptide, was initially isolated as a potent vasoconstrictor from porcine aortic endothelial cells and has now been identified in many tissues throughout the body, including the prostate where it is highly expressed. 5,6 It is a member of a family of three related peptides, ET-1, -2 and -3. 7 Endothelins signal through two G-protein coupled receptors ETA and ETB also expressed in a variety of cell types.…”

Section: Introductionmentioning

confidence: 99%

Bone-specific growth inhibition of prostate cancer metastasis by Atrasentan

Drake

Danke

Henry

2010

Cancer Biology & Therapy

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“…[2][3][4][5] Under normal conditions, ET-1 apparently maintains vascular tone and exerts its action in a variety of tissues and organs. [4][5][6][7][8][9] Recently, through other investigations of endothelin's pleiotropic actions, ET-1 has emerged as an important peptide in a host of biologic functions, including development, cellular proliferation, apoptosis, and cancer. [10][11][12] Endothelin-1 sequence is highly conservative among all mammalian species and most high vertebrates, emphasizing its central role in fundamental biologic processes.…”

Section: Introductionmentioning

confidence: 99%