Endovascular optical coherence tomography intensity kurtosis: visualization of vasa vasorum in porcine carotid artery

Cheng, Kyle H. Y.; Sun, Cuiru; Vuong, Barry; Lee, Kenneth K. C.; Mariampillai, Adrian; Marotta, Thomas R.; Spears, Julian; Montanera, Walter; Herman, Peter R.; Kiehl, Tim-Rasmus; Standish, Beau A.; Yang, Victor X. D.

doi:10.1364/boe.3.000388

Cited by 18 publications

(14 citation statements)

References 26 publications

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“…The present study demonstrates for the first time that OFDI of the human coronary artery accurately corresponds to histology, although VV visualization by OCT in the porcine carotid artery has been previously reported. 10 Unique properties of the OFDI system, including its excellent sensitivity and tissue penetration, 7-9 allow clear visualization of the coronary adventitia. Thus, the OFDI system could be a new modality for VV visualization as compared with the current imaging techniques (eg, IVUS).…”

Section: Images In Cardiovascular Medicine Ofdi Of Adventitial Vasa Vmentioning

confidence: 99%

In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging

Nishimiya

Matsumoto

Takahashi

et al. 2014

Circ J

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Section: Images In Cardiovascular Medicine Ofdi Of Adventitial Vasa Vmentioning

confidence: 99%

In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging

Nishimiya

Matsumoto

Takahashi

et al. 2014

Circ J

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“…Optical coherence tomography (OCT) imaging using optical fiber-based rotary catheter probes provides 2D and 3D visualization of microstructures in tissue and has shown initial success in the cardiovascular [1,2], gastroesophageal [3], and pulmonary systems [4]. These clinical studies suggest that rotary catheters provide useful in-vivo diagnostic information based on the structural morphology in the tissue.…”

Section: Introductionmentioning

confidence: 99%

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

Vuong¹,

Lee²,

Luk³

et al. 2014

Opt. Express

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We report a technique for blood flow detection using split spectrum Doppler optical coherence tomography (ssDOCT) that shows improved sensitivity over existing Doppler OCT methods. In ssDOCT, the Doppler signal is averaged over multiple sub-bands of the interferogram, increasing the SNR of the Doppler signal. We explore the parameterization of this technique in terms of number of sub-band windows, width and overlap of the windows, and their effect on the Doppler signal to noise in a flow phantom. Compared to conventional DOCT, ssDOCT processing has increased flow sensitivity. We demonstrate the effectiveness of ssDOCT in-vivo for intravascular flow detection within a porcine carotid artery and for microvascular vessel detection in human pulmonary imaging, using rotary catheter probes. To our knowledge, this is the first report of visualizing in-vivo Doppler flow patterns adjacent to stent struts in the carotid artery.

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“…In a recent study by our group, it was also demonstrated that EV-OCT can potentially detect vasa vasorum in vivo. 14 Figure 5 shows a representative image of vasospasm of porcine carotid artery. A 3D reconstruction of the spasm segment is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive data visualization for high resolution endovascular carotid arterial wall imaging

et al. 2012

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Carotid angioplasty and stenting is a minimally invasive endovascular procedure that may benefit from in vivo high resolution imaging for monitoring the physical placement of the stent and potential complications. The purpose of this pilot study was to evaluate the ability of optical coherence tomography to construct high resolution 2D and 3D images of stenting in porcine carotid artery. Four Yorkshire pigs were anaesthetized and catheterized. A state-of-the-art optical coherence tomography (OCT) system and an automated injector were used to obtain both healthy and stented porcine carotid artery images. Data obtained were then processed for visualization. The state-of-the-art OCT system was able to capture high resolution images of both healthy and stented carotid arteries. High quality 3D images of healthy and stented carotid arteries were constructed, clearly depicting vessel wall morphological features, stent apposition and thrombus formation over the inserted stent. The results demonstrate that OCT can be used to generate high quality 3D images of carotid arterial stents for accurate diagnosis of stent apposition and complications under appropriate imaging conditions.

show abstract

Endovascular optical coherence tomography intensity kurtosis: visualization of vasa vasorum in porcine carotid artery

Cited by 18 publications

References 26 publications

In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging

In Vivo Visualization of Adventitial Vasa Vasorum of the Human Coronary Artery on Optical Frequency Domain Imaging

High speed, wide velocity dynamic range Doppler optical coherence tomography (Part IV): split spectrum processing in rotary catheter probes

Comprehensive data visualization for high resolution endovascular carotid arterial wall imaging

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