Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine

Zhang, Xue; Cao, Lu; Ji, Benlong; Li, Lingxia; Qi, Zhengtang; Ding, Shuzhe

doi:10.1016/j.exger.2020.110853

Cited by 15 publications

(14 citation statements)

References 42 publications

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“…Thus, if the animals are not acclimatized to the exercise equipment or training situation, introducing animals to exercise regimens after tumor inoculation may carry the bias of introducing a full-blown stress response in the animals, counteracting the antitumor effect of exercise on cancer. Supporting this notion are the few long-term cancer models such as chemically induced liver carcinomas (DEN model) where exercise is introduced after chemical induction, and prior to clinically detectable tumors and yet show a significant impact of exercise [32,35]. It should also be mentioned that a few studies also find an effect of exercise when initiated after tumor inoculation [44,45].…”

Section: Preclinical Data From Rodent Animal Models Of Cancer and Exercisementioning

confidence: 98%

“…Despite the mentioned obvious limitations making direct comparisons between methodologically different studies, there are some quite interesting indications that training regimen and timing of exercise may be important. Exhaustive exercise and extensive high-intensity training have been shown to either promote cancer progression [31] or at best, abolish the tumor limiting effects observed with endurance training [32]. In this respect, data suggest that exhaustive exercise may result in a deeper drop in the lymphocyte level, and suppress the return to baseline for a longer period (than normal endurance training) [33], thus opening an "immunocompromised" window.…”

Section: Preclinical Data From Rodent Animal Models Of Cancer and Exercisementioning

confidence: 99%

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Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo

Olofsson

Jensen

Idorn

et al. 2020

IJMS

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Recent advances in clinical oncology is based on exploiting the capacity of the immune system to combat cancer: immuno-oncology. Thus, immunotherapy of cancer is now used to treat a variety of malignant diseases. A striking feature is that even patients with late-stage disease may experience curative responses. However, most patients still succumb to disease, and do not benefit from treatment. Exercise has gained attention in clinical oncology and has been used for many years to improve quality of life, as well as to counteract chemotherapy-related complications. However, more recently, exercise has garnered interest, largely due to data from animal studies suggesting a striking therapeutic effect in preclinical cancer models; an effect largely mediated by the immune system. In humans, physical activity is associated with a lower risk for a variety of malignancies, and some data suggest a positive clinical effect for cancer patients. Exercise leads to mobilization of cells of the immune system, resulting in redistribution to different body compartments, and in preclinical models, exercise has been shown to lead to immunological changes in the tumor microenvironment. This suggests that exercise and immunotherapy could have a synergistic effect if combined.

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Section: Preclinical Data From Rodent Animal Models Of Cancer and Exercisementioning

confidence: 98%

Section: Preclinical Data From Rodent Animal Models Of Cancer and Exercisementioning

confidence: 99%

Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo

Olofsson

Jensen

Idorn

et al. 2020

IJMS

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“…Gıdalara koruyucu amaçla ilave edilen nitrozaminlerden biri DEN olup, metabolizması monooksijenaz enzimleri tarafından katalizlenmektedir. Dietilnitrozamin biyoaktivasyonu sonucu oluşan süperoksit anyonu gibi reaktif ara ürünlerin ise hücre bileşenleriyle kovalent bağlar oluşturabildiği ve nekrotik etkilerinin yanı sıra DNA mutasyonlarına da neden olarak, başta hepatokarsinom olmak üzere kanser patogenezinde yer aldığı bilinmektedir (2,4,5). Organizmada fizyolojik olarak oksidan ve antioksidan seviyesi dengede tutulmaktadır, fakat stres, kronik hastalık ve enfeksiyonlar immün sistemi uyarmakta, bunun bir sonucu olarak da serbest radikal miktarının artması nedeniyle doku hasarı ve yangı oluşmaktadır (16).…”

Section: Tartişma Ve Sonuçunclassified

Dietilnitrozamin ile İndüklenen Tavşanlarda β-Karotenin Nitrik Oksit ve Malondialdehit Düzeylerine Etkisinin Araştırılması

Merkit

Merhan

2021

Dicle Üniversitesi Veteriner Fakültesi Dergisi

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Asidik ortamda nitroz aside dönüşen nitritler, karsinojenik etkiye sahip N-nitrozo bileşiklerinin prekürsorüdür. Sekonder yapılı aminler, nitroz asitle reaksiyona girerek nitrozamin bileşiklerini oluştururlar. Doğada yaygın olarak bulunan nitrozaminler karsinojenik bileşiklerdir. Bazı kozmetik, pestisit ve çoğu kauçuk ürünlerin imalatında kullanılan nitrozaminler; lateks ürünlerinde, tahıl, çay, birçok gıdada, sigara ve sigara dumanında bulunur. Dietilnitrozamin (DEN) ise nitrozaminlerin en bilindik üyesidir ve hepatik karsinoma neden olabilmektedir (1). Bu yönüyle DEN güncel olarak deneysel karaciğer kanseri oluşturmak için kullanılan kanserojenik ajanlardan biridir (2). Karaciğerde metabolize edildiğinde DNA alkilasyonuna ve oksidatif strese neden olarak kanserojenik etki göstermesi nedeniyle DEN'in erken dönem kanserojenik etkileri, doku ve plazma düzeyinde serbest radikal artışı ve lipit peroksidasyonunun indüksiyonu ile izlenebilmektedir (3-6).

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“…However, Paolucci et al found that compared with MET, HIIT not only decreased depressive symptoms such as MET but also increased perceived stress [ 19 ]. Furthermore, Zhang et al reported that MET may be superior to HIIT in preventing liver cancer development in mice [ 20 ]. Therefore, in this study, we used naturally aging mice subjected to either MET or HIIT regimes.…”

Section: Introductionmentioning

confidence: 99%

Effect of different exercise training intensities on age-related cardiac damage in male mice

Pei

Yang

Guo

et al. 2021

Aging

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Aging is the most important risk factor for cardiovascular diseases. Although exercise is known to be beneficial for the health of aging heart, the optimal exercise training intensity to prevent natural aging-induced cardiac damage has not been defined. In this study, we used 32-week-old male mice and randomly divided them into three groups, namely, untrained (UNT) mice, moderate-intensity exercise training (MET) mice, and high-intensity interval training (HIIT) mice. Mice in the two exercise training groups were subjected to exercise 5 days per week for 24 consecutive weeks. Metabolic characteristics, cardiac function and morphology, myocardial remodeling, myocardial fibrosis (collagen III, α-SMA, and TGF-β), oxidative stress (NRF2, HO-1, SOD, and NOX4), and apoptosis (BAX, Bak, Bcl-2, and Bcl-XL) were analyzed 24 weeks after the different treatments. MET improved cardiac function and reduced myocardial remodeling, myocardial fibrosis, and oxidative stress in the aging heart. MET treatment exerted an anti-apoptotic effect in the heart of the aging mice. Importantly, HIIT did not protect against cardiac damage during the natural aging process. These findings suggest that MET may be one of the main methods to prevent cardiac damage induced by natural aging.

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Endurance training but not high-intensity interval training reduces liver carcinogenesis in mice with hepatocellular carcinogen diethylnitrosamine

Cited by 15 publications

References 42 publications

Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo

Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo

Dietilnitrozamin ile İndüklenen Tavşanlarda β-Karotenin Nitrik Oksit ve Malondialdehit Düzeylerine Etkisinin Araştırılması

Effect of different exercise training intensities on age-related cardiac damage in male mice

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