Enduring neurobehavioural effects in mice induced by early-life microbiota-gut-brain axis disruption: reversal by oxytocin

Morais, Lívia H.; Kannedy, P.J.; Moloney, Gerard M.; Golubeva, Anna V.; Rea, Kieran; Borre, Yuliya; Scott, Karen A.; Patterson, Elaine; Stilling, Roman M.; Moya-Pérez, Ángela; Hoban, Alan E.; Aidy, Sahar El; Beers, S.; O’Sullivan, Órla; Moloney, Rachel D.; Ross, Patrick; Cotter, Paul D.; Stanton, Catherine; Dinan, Timothy G.; Cryan, John F.

doi:10.1016/s0924-977x(17)30107-4

Cited by 2 publications

(1 citation statement)

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“…Specifically, individuals immune-challenged during mid and late developmental stages were more active in novel environments (Butler et al 2012 ). In mice, pups born through C-section showed more anxiety behaviours in later life than those born vaginally, presumably through changes in the microbiota gut-brain axis (Morais et al 2017 ). Similarly, neonatal exposure to environmental bacteria was shown to alter the development of anxiety-like behaviours in Fischer-344 rats, which expressed during adulthood but not during adolescence (Walker et al 2004 ).…”

Section: What In the Early-life Environment Affects Later-life Copingmentioning

confidence: 99%

Why and how the early-life environment affects development of coping behaviours

Langenhof

Komdeur

2018

Behav Ecol Sociobiol

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Understanding the ways in which individuals cope with threats, respond to challenges, make use of opportunities and mediate the harmful effects of their surroundings is important for predicting their ability to function in a rapidly changing world. Perhaps one of the most essential drivers of coping behaviour of adults is the environment experienced during their early-life development. Although the study of coping, defined as behaviours displayed in response to environmental challenges, has a long and rich research history in biology, recent literature has repeatedly pointed out that the processes through which coping behaviours develop in individuals are still largely unknown. In this review, we make a move towards integrating ultimate and proximate lines of coping behaviour research. After broadly defining coping behaviours (1), we review why, from an evolutionary perspective, the development of coping has become tightly linked to the early-life environment (2), which relevant developmental processes are most important in creating coping behaviours adjusted to the early-life environment (3), which influences have been shown to impact those developmental processes (4) and what the adaptive significance of intergenerational transmission of coping behaviours is, in the context of behavioural adaptations to a fast changing world (5). Important concepts such as effects of parents, habitat, nutrition, social group and stress are discussed using examples from empirical studies on mammals, fish, birds and other animals. In the discussion, we address important problems that arise when studying the development of coping behaviours and suggest solutions.Electronic supplementary materialThe online version of this article (10.1007/s00265-018-2452-3) contains supplementary material, which is available to authorized users.

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Section: What In the Early-life Environment Affects Later-life Copingmentioning

confidence: 99%

Why and how the early-life environment affects development of coping behaviours

Langenhof

Komdeur

2018

Behav Ecol Sociobiol

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Perinatal factors affect the gut microbiota up to four years after birth

et al. 2019

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Perinatal factors impact gut microbiota development in early life, however, little is known on the effects of these factors on microbes in later life. Here we sequence DNA from faecal samples of children over the first four years and reveal a perpetual evolution of the gut microbiota during this period. The significant impact of gestational age at birth and delivery mode on gut microbiota progression is evident in the first four years of life, while no measurable effects of antibiotics are found in the first year. Microbiota profiles are also characteristic in children dependant on gestational age and maturity. Full term delivery is characterised by Bacteroides (year one), Parabacteroides (year two) and Christensenellaceae (year four). Preterm delivery is characterised by Lactobacillus (year one), Streptococcus (year two) and Carnobacterium (year four). This study reveals that the gut retains distinct microbial profiles of perinatal factors up to four years of age.

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Enduring neurobehavioural effects in mice induced by early-life microbiota-gut-brain axis disruption: reversal by oxytocin

Cited by 2 publications

References 0 publications

Why and how the early-life environment affects development of coping behaviours

Why and how the early-life environment affects development of coping behaviours

Perinatal factors affect the gut microbiota up to four years after birth

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