Energy metabolism of working muscle: concentration profiles of selected metabolites

Edington, Dee W.; Ward, G.; Saville, WA

doi:10.1152/ajplegacy.1973.224.6.1375

Cited by 39 publications

(8 citation statements)

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“…The mechanisms which account for the CK activity in muscle being the highest at 24 h after exercise are not well understood and are beyond the scope of the present study. The increase in pyruvate, which is one of the glycogen degradation products, seen during endurance exercise agrees with previous findings (EDINGTON et al, 1973). The glycogen level was lowest at 0 h post-exercise, while pyruvate reached its highest level at 1 h post-exercise in both SOL and EDL.…”

Section: Resultssupporting

confidence: 92%

Acute exhaustive exercise changes the metabolic profiles in slow and fast muscles of rat.

Takekura¹,

Yoshioka²

1988

Jpn.J.Physiol

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The effects of acute endurance running on the metabolic profiles of rat skeletal muscle were studied. Male Wistar strain rats were continuously run on a treadmill for 1 h (speed, 35 m/min; grade, 0 degrees). Soleus (SOL) and extensor digitorum longus (EDL) were removed after 30-min running, and a 0, 1, 6, 24, 48, and 72 h post-exercise, and enzymes activity (CK, LDH, PFK, PK, SDH, and MDH) and substrates contents (glycogen and pyruvate) were measured biochemically. The time course of the enzyme activities showed two distinct patterns: CK, LDH, SDH, and MDH showed two peaks, at 0 and 24 h post-exercise, while PFK and PK showed one peak at 0 h post-exercise. The activities of glycolytic enzymes and CK in EDL and oxidative enzymes in SOL showed marked changes after exercise. The glycogen level was lowest at 0 h postexercise in both muscles and recovered to resting level by 24 h postexercise. Pyruvate increased with running and showed the highest value at 1 h post-exercise. Increased oxidative capacity of skeletal muscle in response to the acute endurance exercise dropped gradually to the resting level by 48 h post-exercise. An endurance exercise may induce a flexible adaptation on the oxidative capacity within skeletal muscle. We conclude that the respective time course of the enzyme activities must be considered when discussing metabolic changes that occur with acute endurance exercise.

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Section: Resultssupporting

confidence: 92%

Acute exhaustive exercise changes the metabolic profiles in slow and fast muscles of rat.

Takekura¹,

Yoshioka²

1988

Jpn.J.Physiol

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“…That source is usually considered to be the a-glycerophosphate dehydrogenase reaction, in which case, a-glycerophosphate accumulates as an additional anaerobic end product (12,15,26). Presumably, some controlling mechanism is available to turn on a-glycerophosphate dehydrogenase at the correct time, but as of this writing we are aware of nothing definitive on this matter.…”

Section: Maintenance Of Redox Balance During Anaerobic Glycolysis In mentioning

confidence: 96%

Metabolic Consequences of Diving in Animals and Man

Pw¹,

Storey²

1975

Science

121

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“…The benefits of mitochondrial substrate‐level phosphorylation substantiated by the shift of equilibrium of the succinate thiokinase reaction toward succinate accumulation during anaerobiosis have been also demonstrated in hemorrhagic shock (Chick et al, ) and in hypoxic injury of the proximal kidney tubules (Weinberg et al, ). During oxygen deprivation, an increase in glutamate utilization has been observed in several mammalian tissues, sometimes to the point of depletion (Williamson et al, ; Edington et al, ; Gailis and Benmouyal, ; Taegtmeyer et al, b; Pisarenko et al, ). In cardiac ischemia, malate increases fourfold (Pisarenko et al, ), together with pronounced conversion of α‐ketoglutarate to succinate (Sanborn et al, ; Peuhkurinen et al, ; Pisarenko et al, ); as a result, succinate exits the ischemic organ (Pisarenko et al, ).…”

Section: Hypoxia: All Roads Lead To Succinate?mentioning

confidence: 99%

Which way does the citric acid cycle turn during hypoxia? The critical role of α‐ketoglutarate dehydrogenase complex

Chinopoulos

2013

J of Neuroscience Research

112

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The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states implicating energetic imbalance. In spite of the fact that it is being branded as a 'cycle', during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway remain operational but exhibit opposing directionalities. This serves the purpose of harnessing high energy phosphates through matrix substrate-level phosphorylation in the absence of oxidative phosphorylation. In this mini-review these segments are appraised, pointing to the critical importance of the alpha-ketoglutarate dehydrogenase complex dictating their directionalities.

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Energy metabolism of working muscle: concentration profiles of selected metabolites

Cited by 39 publications

References 0 publications

Acute exhaustive exercise changes the metabolic profiles in slow and fast muscles of rat.

Acute exhaustive exercise changes the metabolic profiles in slow and fast muscles of rat.

Metabolic Consequences of Diving in Animals and Man

Which way does the citric acid cycle turn during hypoxia? The critical role of α‐ketoglutarate dehydrogenase complex

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