It is still possible to comply with the Paris Climate Agreement to maintain a global temperature ‘well below +2.0 °C’ above pre-industrial levels. We present two global non-overshoot pathways (+2.0 °C and +1.5 °C) with regional decarbonization targets for the four primary energy sectors—power, heating, transportation, and industry—in 5-year steps to 2050. We use normative scenarios to illustrate the effects of efficiency measures and renewable energy use, describe the roles of increased electrification of the final energy demand and synthetic fuels, and quantify the resulting electricity load increases for 72 sub-regions. Non-energy scenarios include a phase-out of net emissions from agriculture, forestry, and other land uses, reductions in non-carbon greenhouse gases, and land restoration to scale up atmospheric CO2 removal, estimated at −377 Gt CO2 to 2100. An estimate of the COVID-19 effects on the global energy demand is included and a sensitivity analysis describes the impacts if implementation is delayed by 5, 7, or 10 years, which would significantly reduce the likelihood of achieving the 1.5 °C goal. The analysis applies a model network consisting of energy system, power system, transport, land-use, and climate models.