Engineered core–shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents

Peng, Yung‐Kang; Lui, Cathy N. P.; Chen, Yu Wei; Chou, Shang Wei; Chou, Pi‐Tai; Yung, Kin Lam; Tsang, Shik Chi Edman

doi:10.1088/1361-6528/aa96eb

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…Magnetic NPs including ultrasmall iron oxide and FeCo NPs that intrinsically display both positive and negative contrast effects were utilized to fabricate nanohybrids with biocompatible polymers as T 1 - T 2 dual-modal MR contrast agents. − In other cases, contrast agents for T 1 - and T 2 -weighted MRI were combined in one nanohybrid for dual-modal imaging. PEGylated Mn(II)- or Gd(III)-complexed Fe 3 O 4 nanohybrids as well as Gd 2 O 3 - or MnO-embeded Fe 3 O 4 nanohybrids were all successfully be employed as enhanced T 1 - T 2 dual-modal MR contrast agents. ,− However, magnetic coupling between the T 1 and T 2 contrast agents is inevitable to lead to quenching of both signals when the two parts are close.…”

Section: Versatile Biomedical Applicationsmentioning

confidence: 99%

Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

et al. 2018

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Organic/inorganic nanohybrids have attracted widespread interests due to their favorable properties and promising applications in biomedical areas. Great efforts have been made to design and fabricate versatile nanohybrids. Among different organic components, diverse polymers offer unique avenues for multifunctional systems with collective properties. This review focuses on the design, properties, and biomedical applications of organic/inorganic nanohybrids fabricated from inorganic nanoparticles and polymers. We begin with a brief introduction to a variety of strategies for the fabrication of functional organic/inorganic nanohybrids. Then the properties and functions of nanohybrids are discussed, including properties from organic and inorganic parts, synergistic properties, morphology-dependent properties, and self-assembly of nanohybrids. After that, current situations of nanohybrids applied for imaging, therapy, and imaging-guided therapy are demonstrated. Finally, we discuss the prospect of organic/inorganic nanohybrids and highlight the challenges and opportunities for the future investigations.

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Section: Versatile Biomedical Applicationsmentioning

confidence: 99%

Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

et al. 2018

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“…Magnetic nanoparticles such as super paramagnetic iron oxide (SPION), cobalt, nickel, etc [2,3] have shown special properties, including the superparamagnetic effect, quantum size effect, macroscopic quantum tunneling effect and small size effect of magnetic ordered particles [4] . These properties have been utilized in several applications, such as cell labeling and targeting [5], tissue regeneration [6], targeted drug delivery and magnetic resonance imaging (MRI) [7,8]. Among various natural elements, metal oxides (e.g.…”

Section: Introductionmentioning

confidence: 99%

SPION based magnetic PLGA nanofibers for neural differentiation of mesenchymal stem cells

Mohammadalizadeh¹,

Dabirian²,

Akrami³

et al. 2022

Nanotechnology

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Recently, magnetic platforms have been widely investigated in diagnostic, therapeutic and research applications due to certain properties, such as cell and tissue tracking and imaging, thermal therapy and being dirigible. In this study, the incorporation of magnetic nanoparticles (MNPs) in nanofibers has been proposed to combine the advantages of both nanofibers and MNPs to induce neural differentiation of mesenchymal stem cells. Magnetic poly (lactic-co-glycolic acid) nanofibers (containing 0%, 5% and 10% SPION) were fabricated and utilized as the matrix for the differentiation of mesenchymal stem cells (MSCs). Morphological, magnetic and mechanical properties were analyzed using FESEM, VSM and tensile test, respectively. The expression of neural markers (TUJ-1, NSE, MAP-2) was assessed quantitative and qualitatively utilizing RT-PCR and immunocytochemistry. Results confirmed the incorporation of MNPs in nanofibrous scaffold, presenting a saturation magnetization of 9.73 emu g−1. Also, with increase in magnetic particle concentration (0%–10%), tensile strength increased from 4.08 to 5.85 MPa, whereas the percentage of elongation decreased. TUJ-1 expression was 3.8 and 1.8 fold for 10% and 5% magnetic scaffold (versus non-magnetic scaffold) respectively, and the expression of NSE was 6.3 and 1.2-fold for 10% and 5%, respectively. Consequently, it seems that incorporation of magnetic biomaterial can promote the neural differentiation of MSCs, during which the augmentation of super paramagnetic iron oxide concentration from 0% to 10% accelerates the neural differentiation process.

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO2, MnO, Mn2O3, Mn3O4, and MnOx) and their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, the representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced. First, five kinds of primary synthetic methods of MONs are presented, including thermal decomposition method, exfoliation strategy, permanganates reduction method, adsorption–oxidation method, and hydro/solvothermal. Second, the preparations of hollow MONs and MON‐based composite materials are summarized specially. Then, the chemical properties, surface modification, and toxicity of MONs are discussed. Next, the diagnostic applications including imaging and sensing are outlined. Finally, some representative rational designs of MONs in photodynamic therapy, photothermal therapy, chemodynamic therapy, sonodynamic therapy, radiotherapy, magnetic hyperthermia, chemotherapy, gene therapy, starvation therapy, ferroptosis, immunotherapy, and various combination therapy are highlighted.

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Engineered core–shell magnetic nanoparticle for MR dual-modal tracking and safe magnetic manipulation of ependymal cells in live rodents

Cited by 5 publications

References 36 publications

Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

SPION based magnetic PLGA nanofibers for neural differentiation of mesenchymal stem cells

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

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