Engineered dressing of hybrid chitosan-silica for effective delivery of keratin growth factor and acceleration of wound healing

Oh, Jun-Sung; Lee, Eunjung

doi:10.1016/j.msec.2019.109815

Cited by 21 publications

(21 citation statements)

References 33 publications

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“…The sliced sections were dyed using hematoxylin and eosin (H&E) and observed through the CKX53 microscope (Olympus, Tokyo, Co). [55] In this subcutaneous in vivo study, the biocompatibility between the implanted material and the surrounding tissue, and the biodegradation of the materials measured by the remaining area of the material were evaluated through the H&E-stained histological tissue sections (n = 3).…”

Section: Methodsmentioning

confidence: 99%

Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold

Siebert

Luna‐Cerón

García‐Rivera

et al. 2021

Adv Funct Materials

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Advanced wound scaffolds that integrate active substances to treat chronic wounds have gained significant recent attention. While wound scaffolds and advanced functionalities have previously been incorporated into one medical device, the wirelessly triggered release of active substances has remained the focus of many research endeavors. To combine multiple functions including light-triggered activation, antiseptic, angiogenic, and moisturizing properties, a 3D printed hydrogel patch encapsulating vascular endothelial growth factor (VEGF) decorated with photoactive and antibacterial tetrapodal zinc oxide (t-ZnO) microparticles is developed. To achieve the smart release of VEGF, t-ZnO is modified by chemical treatment and activated through ultraviolet/ visible light exposure. This process would also make the surface rough and improve protein adhesion. The elastic modulus and degradation behavior of the composite hydrogels, which must match the wound healing process, are adjusted by changing t-ZnO concentrations. The t-ZnO-laden composite hydrogels can be printed with any desired micropattern to potentially create a modular elution of various growth factors. The VEGF-decorated t-ZnO-laden hydrogel patches show low cytotoxicity and improved angiogenic properties while maintaining antibacterial functions in vitro. In vivo tests show promising results for the printed wound patches, with less immunogenicity and enhanced wound healing.

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Section: Methodsmentioning

confidence: 99%

Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold

Siebert

Luna‐Cerón

García‐Rivera

et al. 2021

Adv Funct Materials

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“…The high porosity of the silica is also responsible for the enhancement of the adhesion and proliferation of fibroblast cells in the drug-loaded chitosan–silica/poly( ε -caprolactone) wound dressing [ 27 ]. The porosity contributed to the adsorption and sustained release of keratinocyte growth factor from a hybrid chitosan-silica dressing, accelerating wound healing [ 28 ]. An increase of the surface area, due to the silica nanospheres on chitosan materials, was responsible for improved bleeding homeostasis.…”

Section: Relationships Between Silica Properties and Wound Healing Bioactivitymentioning

confidence: 99%

“…For example, from fibrin scaffolds without affecting the cell behavior [ 48 ] and showing wound healing synergic effects on succinyl chitosan/dialdehyde-based oxidized alginate crosslinked injectable hydrogel, favoring collagen/myofibrils accumulation, new blood vessels formation, and L929 fibroblast viability [ 52 ]. On the other hand, silica can also be a reservoir of bioactive compounds, such as keratin growth factors and interleukins, improving and expanding the biological functions of the wound dressings [ 28 , 54 ].…”

Section: Mechanisms Of Silica/protein and Silica/polysaccharide Interactions And Their Impacts On The Functional Properties Of The Derivementioning

confidence: 99%

Silica/Protein and Silica/Polysaccharide Interactions and Their Contributions to the Functional Properties of Derived Hybrid Wound Dressing Hydrogels

Mesa

Becerra

2021

International Journal of Biomaterials

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Multifunctional and biocompatible hydrogels are on the focus of wound healing treatments. Protein and polysaccharides silica hybrids are interesting wound dressing alternatives. The objective of this review is to answer questions such as why silica for wound dressings reinforcement? What are the roles and contributions of silane precursors and silica on the functional properties of hydrogel wound dressings? The effects of tailoring the porous, morphological, and chemical characteristics of synthetic silicas on the bioactivity of hybrid wound dressings hydrogels are explored in the first part of the review. This is followed by a commented review of the mechanisms of silica/protein and silica/polysaccharide interactions and their impact on the barrier, scaffold, and delivery matrix functions of the derived hydrogels. Such information has important consequences for wound healing and paves the way to multidisciplinary researches on the production, processing, and biomedical application of this kind of hybrid materials.

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“…Chitosan combines with negatively charged biomolecules through electrostatic action of positive charge generated by amino protonation in the chain to control the release of encapsulating proteins (Gohil et al, 2017). Additionally, Song et al (Oh & Lee, 2019) indicated that the combination of chitosan and silica dressing loaded with keratinocyte growth factor (KGF) had the characteristics of continuous KGF release. The results have shown that the dressing promotes skin regeneration.…”

Section: Chitosan and Chitinmentioning

confidence: 99%

“…Additionally, Song et al. (Oh & Lee, 2019 ) indicated that the combination of chitosan and silica dressing loaded with keratinocyte growth factor (KGF) had the characteristics of continuous KGF release. The results have shown that the dressing promotes skin regeneration.…”

Section: Applications Of Natural Polysaccharides In Tissue Engineerinmentioning

confidence: 99%

Engineered biomaterial strategies for controlling growth factors in tissue engineering

et al. 2020

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Growth factors are multi-functional signaling molecules that coordinate multi-stage process of wound healing. During wound healing, growth factors are transmitted to wound environment in a positive and physiologically related way, therefore, there is a broad prospect for studying the mediated healing process through growth factors. However, growth factors (GFs) themselves have disadvantages of instability, short life, rapid inactivation of physiological conditions, low safety and easy degradation, which hinder the clinical use of GFs. Rapid development of delivery strategies for GFs has been trying to solve the instability and insecurity of GFs. Particularly, in recent years, GFs delivered by scaffolds based on biomaterials have become a hotspot in this filed. This review introduces various delivery strategies for growth factors based on new biodegradable materials, especially polysaccharides, which could provide guidance for the development of the delivery strategies for growth factors in clinic.

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Engineered dressing of hybrid chitosan-silica for effective delivery of keratin growth factor and acceleration of wound healing

Cited by 21 publications

References 33 publications

Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold

Light‐Controlled Growth Factors Release on Tetrapodal ZnO‐Incorporated 3D‐Printed Hydrogels for Developing Smart Wound Scaffold

Silica/Protein and Silica/Polysaccharide Interactions and Their Contributions to the Functional Properties of Derived Hybrid Wound Dressing Hydrogels

Engineered biomaterial strategies for controlling growth factors in tissue engineering

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