Engineered stem cells targeting multiple cell surface receptors in tumors

Kavari, Sanam L; Shah, Khalid

doi:10.1002/stem.3069

Cited by 8 publications

(5 citation statements)

References 135 publications

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“…To address these problems, MSCs have been transplanted in vivo combined with scaffolds, cultured as a sheet form, or engineered to have targeting ligands. [61][62][63] Likewise, it has been known that spheroids could enhance the engraftment efficiency within the injected area due to their relatively larger volume compared to suspended cells, which increase the therapeutic efficacy of transplanted MSCs. For example, MSC spheroids injected into an ischemic kidney showed an enhanced survival rate and paracrine signaling as compared to dissociated cells by increased retention of transplanted cells within the transplanted tissue.…”

Section: In Vivo Therapeutic Applications Of Spheroidsmentioning

confidence: 99%

Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine

Kim

Yamamoto

et al. 2020

Adv Healthcare Materials

150

104

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Multi-cellular spheroids are formed as a 3D structure with dense cell-cell/cell-extracellular matrix interactions, and thus, have been widely utilized as implantable therapeutics and various ex vivo tissue models in tissue engineering. In principle, spheroid culture methods maximize cell-cell cohesion and induce spontaneous cellular assembly while minimizing cellular interactions with substrates by using physical forces such as gravitational or centrifugal forces, protein-repellant biomaterials, and micro-structured surfaces. In addition, biofunctional materials including magnetic nanoparticles, polymer microspheres, and nanofiber particles are combined with cells to harvest composite spheroids, to accelerate spheroid formation, to increase the mechanical properties and viability of spheroids, and to direct differentiation of stem cells into desirable cell types. Biocompatible hydrogels are developed to produce microgels for the fabrication of size-controlled spheroids with high efficiency. Recently, spheroids have been further engineered to fabricate structurally and functionally reliable in vitro artificial 3D tissues of the desired shape with enhanced specific biological functions. This paper reviews the overall characteristics of spheroids and general/advanced spheroid culture techniques. Significant roles of functional biomaterials in advanced spheroid engineering with emphasis on the use of spheroids in the reconstruction of artificial 3D tissue for tissue engineering are also thoroughly discussed.

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Section: In Vivo Therapeutic Applications Of Spheroidsmentioning

confidence: 99%

Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine

Kim

Yamamoto

et al. 2020

Adv Healthcare Materials

150

104

View full text Add to dashboard Cite

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“…Additionally, MSCs as a possible means can deliver oncolytic viruses (OVs), which can overcome host antiviral immunity [ 159 ]. MSCs armed by oncolytic herpes simplex virus (oHSV) successfully delivered viral progeny to target melanoma brain metastasis, ultimately inhibiting tumor growth rate and prolonging survival of brain tumor-bearing mice [ 159 , 160 ]. Although many research examples of immunomodulation and delivery are successful, we still need more work.…”

Section: Improvement Of Immunomodulatory Capabilities and Therapeutic...mentioning

confidence: 99%

Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells

Yang

Fan

Liu

et al. 2023

Stem Cell Rev and Rep

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Mesenchymal stem cells (MSCs) are regarded as highly promising cells for allogeneic cell therapy, owing to their multipotent nature and ability to display potent and varied functions in different diseases. The functions of MSCs, including native immunomodulation, high self-renewal characteristic, and secretory and trophic properties, can be employed to improve the immune-modulatory functions in diseases. MSCs impact most immune cells by directly contacting and/or secreting positive microenvironmental factors to influence them. Previous studies have reported that the immunomodulatory role of MSCs is basically dependent on their secretion ability from MSCs. This review discusses the immunomodulatory capabilities of MSCs and the promising strategies to successfully improve the potential utilization of MSCs in clinical research. Graphical Abstract

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“…They play the central role in the homeostasis and regeneration of all body tissues. SCs exhibit inherent tropism for cancer cells, which makes them an ideal therapeutic vehicle in anticancer therapy [105,106] (Table 2).…”

Section: Stem Cells and Progenitor Cellsmentioning

confidence: 99%

A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Motais

Charvátová

Hrdinka

et al. 2020

Cancers

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Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.

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Engineered stem cells targeting multiple cell surface receptors in tumors

Cited by 8 publications

References 135 publications

Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine

Engineering Multi‐Cellular Spheroids for Tissue Engineering and Regenerative Medicine

Immunomodulatory Mechanisms and Therapeutic Potential of Mesenchymal Stem Cells

A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

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