Engineering polyphenol-based polymeric nanoparticles for drug delivery and bioimaging

Wang, Xinyu; Fan, Yeli; Yan, Junjie; Yang, Min

doi:10.1016/j.cej.2022.135661

Cited by 69 publications

(43 citation statements)

References 168 publications

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“…In terms of bioactive biomaterials, polyphenols have been reported to be able to extensively combine with bioactive molecules (DNA, RNA, protein), and the biomaterials composed of MPNs and bioactive molecules is highly anticipated (Figure 14). [183][184][185] Further, in the context of artificial intelligence, biomaterials with intelligent responsiveness and smart functions will attract much attention. In addition to the stimuli responsiveness (pH, temperature, fluorescence) that have been reported for MPNs, some MPNs structures have also been found to have unique phototaxis characteristics in recent years.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

et al. 2022

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Due to the abuse of antibiotics and the emergence of multidrug resistant microorganisms, medical devices, and related biomaterials are at high risk of microbial infection during use, placing a heavy burden on patients and healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, and antibacterial properties by making use of the coordination between phenolic ligands and metal ions. Further, MPNs have received widespread attention in antimicrobial infections due to their facile synthesis process, excellent biocompatibility, and excellent antimicrobial properties brought about by polyphenols and metal ions. In this review, different categories of biomaterials based on MPNs (nanoparticles, coatings, capsules, hydrogels) and their fabrication strategies are summarized, and recent research advances in their antimicrobial applications in biomedical fields (e.g., skin repair, bone regeneration, medical devices, etc.) are highlighted.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

et al. 2022

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“…Moreover, polyphenols also have excellent biological activity, attracting increased attention with regard to functional natural materials in recent years. The abundant phenolic hydroxyl groups in the structure can be used for the surface modification of nanomaterials 130 through coordination bonds, covalent bonds, and hydrogen bonds 131 with other molecules or groups, which provides the materials with a variety of excellent biological activities and greatly promotes the development of polyphenols in the surface functionalization of materials.…”

Section: ■ Synthetic Polymers Membrane Coatingmentioning

confidence: 99%

“…It has shown unique application prospects in vast fields, mainly focusing on biomedicine and drug delivery. At present, the substrates of MPN coating in the field of antitumor therapy mainly utilize tea polyphenol (TA), epigallocatechin gallate (EGCG), and epicatechin, derived from tea polyphenols, which can coordinate with metal ions (e.g., Fe, Gd, and Cu) to form a supramolecular self-assembled MPN membrane, because of the presence of a common structure of multiple phenolic hydroxyl groups via chelate reaction . There are many advantages of MPN membrane as coating, including favorable biocompatibility and minimal toxicity, antioxidant capacities, low cost, pH/GSH responsiveness, and universal adhesion to diverse substrates .…”

Section: Polyphenols Membrane Coatingmentioning

confidence: 99%

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

Wang

et al. 2022

ACS Materials Lett.

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Antitumor nanoparticles now confront several obstacles, including poor biocompatibility and biodegradability, quick removal, and a short cycle time, given the growing interest in surface membrane coating as a versatile platform for altering nanoparticles and overcoming the limitations of current nanodrug delivery methods. This paper reviews the recent progress of cells, synthetic polymers, polyphenols, and polysaccharides membrane coatings with favorable biocompatibility and biodegradability and easy surface modification on the surface of antitumor nanoparticle platforms, which can provide a promising strategy for endowing nanoparticles with specific and expected performance to optimize the efficiency of antitumor. Furthermore, multiple membrane combination strategies and additional biorecognition ligands modification on the membrane surface are supplied in an attempt to tackle the challenges of single membrane coating in a variety of tumor therapeutic applications and ultimately facilitate effective clinical transformation.

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“…Protein-based nanomaterials offer advantages such as biodegradability and biocompatibility. 24 Zein is the main storage protein in corn endosperm, 25 and it contains hydrophobic, neutral, and polar amino acids. It is typically only soluble in an aqueous 60–95% ethanol solution.…”

Section: Introductionmentioning

confidence: 99%

“…The smaller size of nanoparticles allows them to be used as carriers of drugs into the body, improving their bioaccessibility. Protein-based nanomaterials offer advantages such as biodegradability and biocompatibility . Zein is the main storage protein in corn endosperm, and it contains hydrophobic, neutral, and polar amino acids.…”

Section: Introductionmentioning

confidence: 99%

Zein-Based Nanomedicines for Synergistic Chemodynamic/Photodynamic Therapy

Wang

Shi

et al. 2022

ACS Omega

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Current cancer treatment is not only limited to monotherapy but is also influenced by limited drug delivery options. Combined chemokinetic-photokinetic therapy has great promise in enhancing anticancer effects. Meanwhile, zein has superior self-assembly properties and can be loaded with photosensitizers. Herein, the targeted multifunctional nanoparticles based on zein/hyaluronate acid (HA)/tannin (TA)/Cu 2+ loaded with IR780 (ZHTC@IR780) are constructed for synergetic cancer therapy by chemo-dynamic therapy (CDT) and photodynamic therapy (PDT). There is experimental proof that ZHTC@IR780 nanoparticles (NPs) can relieve the tumor hypoxic microenvironment by catalytic decomposition of endogenous H 2 O 2 to O 2 and further react with O 2 to produce toxic 1 O 2 with 808 nm laser irradiation. The glutathione oxidase-like effects of ZHTC@IR780 NPs can generate Fenton-like Cu + ions and deplete GSH for efficient hydroxyl radical ( • OH) production. In addition, CDT combined with PDT enhances the antitumor effect. Photodynamic therapy can cause immunogenic cell death, increase calreticulin eversion, release histone with high mobility, and promote apoptosis of tumor cells.

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Engineering polyphenol-based polymeric nanoparticles for drug delivery and bioimaging

Cited by 69 publications

References 168 publications

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles

Zein-Based Nanomedicines for Synergistic Chemodynamic/Photodynamic Therapy

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