2011
DOI: 10.1172/jci44489
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Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions

Abstract: Stem cell-based therapy has been proposed as a potential means of treatment for a variety of brain disorders. Because ethical and technical issues have so far limited the clinical translation of research using embryonic/ fetal cells and neural tissue, respectively, the search for alternative sources of therapeutic stem cells remains ongoing. Here, we report that upon transplantation into mice with chemically induced hippocampal lesions, human olfactory ecto-mesenchymal stem cells (OE-MSCs) -adult stem cells fr… Show more

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Cited by 119 publications
(115 citation statements)
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“…13 Several studies have reported that OE-MSC transplantation can induce neurogenesis and restore hippocampal neuronal networks in mice. 14 However, it remains largely unknown whether OE-MSCs, which are similar to other types of MSCs, possess any immunoregulatory functions. Moreover, the potential utilization of OE-MSCs for the treatment of autoimmune diseases has not yet been explored.…”
Section: Introductionmentioning
confidence: 99%
“…13 Several studies have reported that OE-MSC transplantation can induce neurogenesis and restore hippocampal neuronal networks in mice. 14 However, it remains largely unknown whether OE-MSCs, which are similar to other types of MSCs, possess any immunoregulatory functions. Moreover, the potential utilization of OE-MSCs for the treatment of autoimmune diseases has not yet been explored.…”
Section: Introductionmentioning
confidence: 99%
“…To test this hypothesis, we studied (1) BM-MSCs [25]; (2) olfactory ectomesenchymal SCs (OEMSCs), which are distributed in the olfactory lamina propria and induce neurogenesis, and restore the hippocampal neuronal network [44][45][46]; (3) non-MSC leptomeningeal SCs (LeSCs), described by us first in rats as nestin-positive cells capable of differentiating into neuronal, astrocyte, and oligodendrocyte precursors [47,48] and, more recently, in mice and humans (personal observation); and (4) human c-Kitpositive SCs isolated from the amniotic fluid (AFSCs) [49], from the adult heart (cardiac SCs: CSCs) [50][51][52]; and adult lung SCs (LSCs) [53]. AFSCs are multipotent, nonteratogenic cells with characteristics intermediate between embryonic and adult SCs [49].…”
Section: Introductionmentioning
confidence: 99%
“…In vivo studies with each SC type are mandatory to assess the role of these immunological features in SC engraftment and regenerative potential. Similarly, further in vivo studies in animal models will clarify whether these considerations on CSCs and LSCs may be applied also to other c-Kit-positive SC populations, such as AFSCs [49], or to non-MSC SCs with in vitro and in vivo neurogenic potential, such as OE-MSCs [44][45][46] and LeSCs [47,48]. As far as the general features related to the acquisition of the immune regulatory functions are concerned, the immunophenotype of the different SCs revealed a common switch, in response to inflammatory priming, from a resting to an activated immunosuppressive pattern.…”
mentioning
confidence: 99%
“…De acordo com Nivet et al (2011), ratos com lesão no hipocampo tiveram neuroplasticidade recuperada após o tratamento por xenotransplante com células-tronco do epitélio olfatório humano. Outros estudos mostraram melhoras no comportamento e nas lesões do corpo estriado de ratos utilizados como modelo animal para o estudo de Parkinson (Murrell et al 2008, Wang et al 2012.…”
Section: Aplicações No Tratamento De Dor Neuropática E De Doenças Neuunclassified