Enhanced Cellular Uptake of Remnant High-Density Lipoprotein Particles

Xiao, Changting; Watanabe, Takehiko; Zhang, Yi; Trigatti, Bernardo L.; Szeto, Linda; Connelly, Philip W.; Marcovina, Santica M.; Vaisar, Tomáš; Heinecke, Jay W.; Lewis, Gary F.

doi:10.1161/circresaha.108.178756

Cited by 31 publications

(9 citation statements)

References 60 publications

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“…Our observation that the hyperalphalipoproteinaemic participants have increased post-heparin lipoprotein lipase activity and diminished hepatic lipase activity compared with the hypoalphalipoproteinaemic participants is in agreement with a previous report [41]. Due to the high-HDL insulin-sensitive state in hyperalphalipoproteinaemia binding and internalization rates of triglyceride-enriched HDL may slow down [42]. Thus, our results conform to the following chain of events described in a previous review [43].…”

Section: Discussionsupporting

confidence: 93%

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Leança

Nunes

Panzoldo

et al. 2013

Cardiovasc Diabetol

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BackgroundWe have searched if plasma high density lipoprotein-cholesterol (HDL-C) concentration interferes simultaneously with whole-body cholesterol metabolism and insulin sensitivity in normal weight healthy adult subjects.MethodsWe have measured the activities of several plasma components that are critically influenced by insulin and that control lipoprotein metabolism in subjects with low and high HDL-C concentrations. These parameters included cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PLTP), lecithin cholesterol acyl transferase (LCAT), post-heparin lipoprotein lipase (LPL), hepatic lipase (HL), pre-beta-1HDL, and plasma sterol markers of cholesterol synthesis and intestinal absorption.ResultsIn the high-HDL-C group, we found lower plasma concentrations of triglycerides, alanine aminotransferase, insulin, HOMA-IR index, activities of LCAT and HL compared with the low HDL-C group; additionally, we found higher activity of LPL and pre-beta-1HDL concentration in the high-HDL-C group. There were no differences in the plasma CETP and PLTP activities.ConclusionsThese findings indicate that in healthy hyperalphalipoproteinemia subjects, several parameters that control the metabolism of plasma cholesterol and lipoproteins are related to a higher degree of insulin sensitivity.

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Section: Discussionsupporting

confidence: 93%

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Leança

Nunes

Panzoldo

et al. 2013

Cardiovasc Diabetol

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“…CETP transports CE from HDL to VLDL in exchange for TG. The TG-enriched HDL is susceptible for hepatic lipase activity, which can result in the formation of HDL remnants like the lipid-poor pre ␤ -1 and ␣ -4 particles ( 34 ). As a result of a decrease in HDL size, the fractional catabolic rate of HDL increases ( 35 ), which may provide a possible explanation for the lower baseline levels of key HDL components (HDL-C, apoA-I, and apoA-II) in obese subjects.…”

Section: Discussionmentioning

confidence: 99%

Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

Asztalos

Swarbrick

Schaefer

et al. 2010

The Journal of Lipid Research

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Journal of Lipid ResearchCardiovascular disease (CVD) is the leading cause of death and disability in the United States. Obesity is associated with hypertension, diabetes, elevated triglyceride (TG) levels, and decreased HDL-cholesterol (HDL-C) levels, all acknowledged as independent CVD risk factors by the AHA ( 1 ). Obesity, defi ned by body mass index (BMI) у 30 kg/m 2 , often coexists with the metabolic syndrome, which is associated with increased CVD risk. High BMI has been associated with increased risk for the development of coronary, cerebral, and peripheral vascular disease; however, due to the coexistence of multiple risk factors, the quantitative assessment of CVD risk exclusively associated with obesity is complicated.Bariatric surgery is an effective intervention to achieve long-term marked weight reduction in patients with morbid obesity ( 2, 3 ). It has recently been published that calculated 10 year CVD risk (based on the Framingham equation) in morbidly obese subjects decreased by 1.3% 12 months after laparoscopic Roux-en-Y gastric bypass (RYGBP) surgery ( 4 ) and that substantial weight loss, following RYGBP surgery, Abstract Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT)and cholesteryl ester transfer protein ( CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were signifi cantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, ␣ -1 and ␣ -2 levels were signifi cantly lower. Over 1 year, signifi cant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and pre ␤ -1 levels were observed with signifi cant increases of HDL-C and ␣ -1 levels (all P < 0.05). Changes of fat mass were correlated with those of LDL cholesterol ( P = 0.018) and LCAT mass ( P = 0.011), but not with CETP mass ( P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass ( P = 0.005) and ␣ -1 level ( P = 0.004). Changes of fasting plasma insulin concentrations were positively correlated with those of LCAT mass ( P = 0.043) and inversely with changes of ␣ -1 ( P = 0.03) and ␣ -2 ( P = 0.05) concentrations. These results demonstrate benefi cial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients. -Asztalos, B.

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“…One explanation proposed by Xiao et al [35] demonstrated that compared to native and TG-rich HDL, the binding of remnant HDL was markedly higher in both HepG2 cells and HEK293 cells. Remnant HDL was internalized to a greater extent in both cell types and was more readily degraded in HEK293 cells.…”

Section: Changes In Hdl Componentmentioning

confidence: 99%

New insights into the mechanism of low high-density lipoprotein cholesterol in obesity

2011

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Obesity, a significant risk factor for various chronic diseases, is universally related to dyslipidemia mainly represented by decreasing high-density lipoprotein cholesterol (HDL-C), which plays an indispensible role in development of cardiovascular disease (CVD). However, the mechanisms underlying obesity and low HDL-C have not been fully elucidated. Previous studies have focused on the alteration of HDL catabolism in circulation following elevated triglyceride (TG). But recent findings suggested that liver and fat tissue played pivotal role in obesity related low HDL-C. Some new molecular pathways like microRNA have also been proposed in the regulation of HDL metabolism in obesity. This article will review recent advances in understanding of the potential mechanism of low HDL-C in obesity.

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Enhanced Cellular Uptake of Remnant High-Density Lipoprotein Particles

Cited by 31 publications

References 60 publications

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Metabolism of plasma cholesterol and lipoprotein parameters are related to a higher degree of insulin sensitivity in high HDL-C healthy normal weight subjects

Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

New insights into the mechanism of low high-density lipoprotein cholesterol in obesity

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