Enhanced mechanical properties and hydrophilic behavior of magnesium oxide added hydroxyapatite nanocomposite: A bone substitute material for load bearing applications

Kumar, Sunil; Gautam, Chandkiram; Chauhan, Brijesh Singh; Srikrishna, Saripella; Yadav, Ram Sagar; Bahadur, S.

doi:10.1016/j.ceramint.2020.03.180

Cited by 38 publications

(17 citation statements)

References 61 publications

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“…Kumar et al [42] synthesized HA-MgO composites using 0, 0.25, 0.5, 1 and 2% MgO by melting infiltration. The mass loss, after 21 days in SBF, of pure HA is 0.43 ± 0.08 mg, which is significantly higher than the HA-1.0 MgO composite (0.21 ± 0.03 mg).…”

Section: Castingmentioning

confidence: 99%

Mg-Based Composites for Biomedical Applications

Castro¹,

Lopes²,

Dias³

2022

Magnesium Alloys Structure and Properties

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Magnesium (Mg) is a promising material for producing temporary orthopedic implants, since it is a biodegradable and biocompatible metal which density is very similar to that of the bones. Another benefit is the small strength mismatch when compared to other biocompatible metals, what alleviates stress-shielding effects between bone and the implant. To take advantage of the best materials properties, it is possible to combine magnesium with bioactive ceramics and tailor composites for medical applications with improved biocompatibility, controllable degradation rates and the necessary mechanical properties. To properly insert bioactive reinforcement into the metallic matrix, the fabrication of these composites usually involves at least one high temperature step, as casting or sintering. Yet, recent papers report the development of Mg-based composites at room temperature using severe plastic deformation. This chapter goes through the available data over the development of Mg-composites reinforced with bioactive ceramics, presenting the latest findings on the topic. This overview aims to identify the major influence of the processing route on matrix refinement and reinforcement dispersion, which are critical parameters to determine mechanical and corrosion properties of biodegradable Mg-based composites.

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Section: Castingmentioning

confidence: 99%

Mg-Based Composites for Biomedical Applications

Castro¹,

Lopes²,

Dias³

2022

Magnesium Alloys Structure and Properties

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“…The best mechanical properties were found for the NCP HA-1.0 MgO (e.g., compressive strength 111.20 ± 5 MPa, fracture toughness 136.98 ± 5 MJ/m 3 ) compared to the pure n-HA. The NCP surface had a hydrophilic nature, and biocompatibility in terms of cell viability was also reported [188].…”

Section: Silicates and Claysmentioning

confidence: 99%

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Jampílek

Plachá

2021

Pharmaceutics

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Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

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“…226 There is a major drawback if such HAps are to be used for load-bearing applications (bone/hard tissue regeneration). 227 However, substituting Ca 2+ in HAp with strontium, terbium, magnesium, and zinc can improve the mechanical properties of such HAps. 228…”

Section: Mechanical Strengthmentioning

confidence: 99%