Enhanced neoplastic lesion development with adenine-induced experimental multicystic nephropathy by adenine — a model system for the analysis of renal tumor generation in long-term hemodialysis patients

Classification of Renal Proliferative Lesions in Rats and/or Mice and Their Diagnostic Problems: Report from the Working Group of the Japanese Society of Toxicologic Pathology.

“…The lesion was observed in the severe damaged kidney where normal architecture was almost destroyed. Some nephrotoxic chemicals are known to induce the lesion although spontaneous occurrence of the lesion is rare except for severely affected kidney with aging such as advanced chronic progressive nephropathy 3,5 . Histogenesis of this type cell remains to be unclear, however this lesion has been considered to have the multi-potent capability to differentiate to tubular or proximal tubular epithelial cell 3 .…”

“…Renal tumors in rodents, particularly rats, have been induced by the exposure to a variety of agents, namely chemical carcinogens, irradiation or oncogenic virus 1,2 , whereas their spontaneous occurrence is rare. On the other hand, the possibility that chronic treatment with some nephrotoxic chemicals lead to renal neoplasm development could not ruled out [3][4][5] . Therefore, the underlying renal tumor development is important not only for the research on renal carcinogenesis but also the aspects of toxicologic pathology.…”