Enhanced photodynamic therapy of TiO2/N-succinyl-chitosan composite for killing cancer cells

Ma, Min; Cheng, Liang; Liang, Xingxing; Yang, Linjiao; Zhang, Aiping

doi:10.1590/s2175-97902022e181116

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…TiO 2 can also be combined with N‐succinyl chitosan composite as TiO 2 / NSCS, which has a significant killing effect on glioma cells under UV irradiation, and the killing effect is positively correlated with the concentration of NPs and irradiation time. [ 92 ]…”

Section: Nanocarriers For Targeted Brain Tumor Therapymentioning

confidence: 99%

“…Ma et al constructed water-dispersible TiO 2 -NPs by chemically modifying polyethylene glycol (PEG) adsorbed on the TiO 2 surface. [92] They then investigated its photocatalytic antitumor effect on rat glioma cells and constructed a spherical model to evaluate the therapeutic response. After UV irradiation of 13.5 J cm -2 , more than 90% of the cells were killed, and compared with the control group.…”

Section: Metallic Compound Nanoparticlesmentioning

confidence: 99%

“…TiO 2 can also be combined with N-succinyl chitosan composite as TiO 2 / NSCS, which has a significant killing effect on glioma cells under UV irradiation, and the killing effect is positively correlated with the concentration of NPs and irradiation time. [92] CeO 2 Nanoparticles (CeO 2 NPs): Glioblastoma is predominantly glycolytic, and hypoxia-induced factors are important in tumor metabolism, so the development of therapies to counteract hypoxia is key to improving clinical outcomes in GBM. [93] CeO 2 NPs attenuate high reactive oxygen species (ROS) levels in GBM cells and modulate the cytotoxic effects of TMZ in the TME.…”

Section: Metallic Compound Nanoparticlesmentioning

confidence: 99%

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Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Wang

Shi

Jiang

et al. 2022

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His research interests include translational studies in the development of new therapies and biomarkers for prognosis and prediction of therapy, and mechanism investigation of treatment resistance in lymphoma. Yinyan Wang is a neurosurgeon and doctoral supervisor at Beijing Tiantan Hospital, and he is a principal investigator for the National Research Center of Neurological Diseases, a principal investigator for China Institute for Brain Research, Beijing. He focused on the individualized precise treatment of gliomas, and he published 72 papers in this field. Lin Feng is an associate professor/doctoral supervisor of Beihang University, "Beijing New Star of Science and Technology." He is a member of the IEEE International Technical Committee on Micro and Nano Robotics, a member of the SCI-indexed journal "Bio-Design and Manufacturing," "Frontiers in Robotics and AI," Science cooperative journal "Cyborg and Bionic Systems." He has published more than 115 academic papers and one textbook on "Introduction to Micro and Nano Robotics." His research interests include precision technology and medical fundamental research on targeted drug delivery field-controlled micro-nanorobots, which is supported by the National Key R&D Program for Intelligent Robotics.

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Section: Nanocarriers For Targeted Brain Tumor Therapymentioning

confidence: 99%

Section: Metallic Compound Nanoparticlesmentioning

confidence: 99%

Section: Metallic Compound Nanoparticlesmentioning

confidence: 99%

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Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Wang

Shi

Jiang

et al. 2022

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TiO2 Nanoparticles in Cancer Therapy as Nanocarriers in Paclitaxel’s Delivery and Nanosensitizers in Phototherapies and/or Sonodynamic Therapy

Tonelli

Cordeiro

2023

CPB

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Nanomaterials have been offering improvements in different areas due to their unique characteristics, but cytotoxicity associated with their use is still a topic that concerns researchers. Causing cell death, at first glance, may seem to be a problem and the studies regarding signaling pathways involved in this toxicity are still in their infancy. However, there are scenarios in which this feature is desirable, such as in cancer treatment. Anti-cancer therapies aim to eliminate the cells of malignant tumors as selectively as possible. From this perspective, titanium dioxide (TiO2) nanoparticles (NPs) deserve to be highlighted as important and efficient tools. Besides being able to induce cell death, these NPs can also be used to deliver anti-cancer therapeutics. These drugs can originate from natural sources, such as paclitaxel (an antitumoral molecule derived from a vegetal source). The present review aims to explore the recent knowledge of TiO2 NPs as nanocarriers (promoting the nanodelivery of paclitaxel) and as nanosensitizers to be used in phototherapies and/or sonodynamic therapy aiming to treat cancer. Signaling pathways triggered by this nanomaterial inside cells leading to apoptosis (a desirable fate when targeting tumor cells) and challenges related to the clinical translation of these NPs will also receive attention in the future.

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Enhanced photodynamic therapy of TiO2/N-succinyl-chitosan composite for killing cancer cells

Cited by 2 publications

References 27 publications

Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

Micro‐Nanocarriers Based Drug Delivery Technology for Blood‐Brain Barrier Crossing and Brain Tumor Targeting Therapy

TiO2 Nanoparticles in Cancer Therapy as Nanocarriers in Paclitaxel’s Delivery and Nanosensitizers in Phototherapies and/or Sonodynamic Therapy

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